CAS: 14338-32-0; 2-Chloro-1-Methylpyridinium Iodide

该化合物是一种含有分子式C6H7ClN-I的四铵盐,这种混合物广泛用作有机合成的多用途试剂,特别是在核生殖器替代和混合反应方面.这种化合物的强烈烷基特性使其能有效地将甲基组引入目标分子.碘化反离子会增加极地溶剂溶解性,有利于同质反应条件.这种试剂因其在环境条件下的稳定性和与核素的高度再活动,能够进行高效转化而受到重视.它发现药物中间体和物质科学的应用,因为其在甲基反应方面的可靠性能.晶体固态保证在实验室环境中方便地处理和准确使用.

结构式图片

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CAS号109-09-1 2-氯吡啶 | CAS号74-88-4 碘甲烷 | CAS号199000-78-7 7-(二苯基甲基)-6-氧代-... | CAS号106-02-5 环十五内酯 | CAS号694-85-9 1-甲基-2-吡啶酮 | CAS号102-16-9 苯乙酸苯甲酯 | CAS号109-09-1 2-氯吡啶 | CAS号56-40-6 甘氨酸

合成工艺路线路线简述

    2-氯吡啶,碘甲烷 反应 2.0H,以37%的收率获得2-氯-1-甲基吡啶碘化物
    参考文献:Stereoselective Synthesis Of 2-[1-Methylpyridin-2(1H)-Ylidene]Malononitrile Derivatives
    标题:Stereoselective Synthesis Of 2-[1-Methylpyridin-2(1H)-Ylidene]Malononitrile Derivatives
    摘要:已确认一种高效合成2-[1-甲基吡啶-2(1H)-亚烯基]马ろん腈衍生物的方法,该反应已被证明具有立体选择性;取代基的空间位置已被确定.
    Doi:10.1055/s-2008-1072578

    海关参考信息

    专利信息


    专利号:US-2012177593-A1
    优先权日:2009-07-20
    标 题 :Synthesis of dendrimer conjugates
    发明人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
    权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
    摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

    专利号:US-2023339844-A1
    优先权日:2020-09-17
    标题:A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof
    发明人:MAHAPATRA TRIDIB; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M; MAL SANJIB; SHARMA RAJU
    权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD
    摘要:The present invention disclosed a process for the synthesis of compound of formula (Z) or a salt thereof, n n n n n n n n n n wherein, R, R 1 , R 2 , R 3 and R 10 are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

    专利号:US-2023339906-A1
    优先权日:2020-09-26
    标 题 :A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof
    发明人:SYTHANA SURESH KUMAR; NAGLE PRAMOD; KUMAR VIJAY KUMAR; KANAWADE SHRIKANT BHAUSAHEB; CHANDRE TUKARAM NIVRUTTI; THUBE VINAYAK KISAN; PATIL PRADEEP PRAKASH; SHUKLA SHALINI; SHENDE KANTILAL BALU; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M
    权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD
    摘要:The present invention discloses a process for the synthesis of compound of formula (VII) or a salt thereof,wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

    专利号:EP-0343716-A1
    优先权日:1988-05-23
    标 题 :Process for synthesis of a beta-lactam carbapenem intermediate
    发明人:LOEWE MALLORY F; CVETOVICH RAYMOND; HAZEN GEORGE G
    权利人:MERCK & CO INC
    摘要:A process is described for the synthesis of 3(S)-4(R)-3-[1(S)-hydroxyethyl]-4-(alkoxycarbonyl­methyl)-azetidin-2-one (II) which is a useful intermediate in the synthesis of carbapenem antibiotics.

    专利号:US-5037974-A
    优先权日:1988-05-23
    标题:Cyclization process for synthesis of a beta-lactam carbapenem intermediate
    发明人:LOEWE MALLORY F; CVETOVICH RAYMOND; HAZEN GEORGE G
    权利人:MERCK & CO INC
    摘要:A process is described for the synthesis of 3(S)-4(R)-3-[1(S)-hydroxyethyl]-4-(alkoxycarbonylmethyl)-azetidin-2-one (II) which is a useful intermediate in the synthesis of carbapenem antibiotics.

    专利号:US-RE41366-E
    优先权日:2001-06-15
    标 题 :Total synthesis of galanthamine, analogues and derivatives thereof
    发明人:THAL CLAUDE; GUILLOU CATHERINE; BEUNARD JEAN-LUC; GRAS EMMANUEL; POTIER PIERRE
    权利人:CT NAT DEL LA RECH SCIENT CNRS
    摘要:The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R 1 =a hydrogen atom, R 2 =a hydroxy group, R 1 and R 2 together form â•?O, R 3 , R 4 , and R 5 independently=a hydrogen atom, a hydroxy group or a (C 1 -C 2 )alkoxy group, R 6 â•?H, (C 1 -C 12 )alkyl, (CH 2 ) n NR 7 R 8 , or —(CH 2 ) n N + R 7 R 8 R 9 where n=1 to 12, Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a —SO, —SO 2 , or —NR 6 group where R 6 is as defined above or is an amine protecting group.
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    主要参考文献

    [参考文献]: Ming-Kung Yeh, Et Al. Studies On A Novel Gelatin Sponge: Preparation And Characterization Of Cross-Linked Gelatin Scaffolds Using 2-Chloro-1-Methylpyridinium Iodide As A Zero-Length Cross-Linker. J Biomater Sci Polym Ed. 2012;23(7):973-90.
    [参考文献]: Qizhi Hu, Et Al. Complete Regression Of Breast Tumour With A Single Dose Of Docetaxel-Entrapped Core-Cross-Linked Polymeric Micelles. Biomaterials. 2015:53:370-8.
    [参考文献]: W Keese, Et Al. [参考文献]: Biol Chem Hoppe Seyler. 1985 Dec;366(12):1093-5.

    合成参考文献


    摘要:Merck Index - O'Neil MJ, Heckelman PE, Dobbelaar PH, Roman KJ (eds). The Merck Index, An Encyclopedia of Chemicals, Drugs, and Biologicals, 15th Ed. Cambridge, UK: The Royal Society of Chemistry, 2013.
    摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2014).
    摘要:Begtrup, M., Science of Synthesis, (2004) 13, 838.
    摘要:Spitzner, D., Science of Synthesis, (2005) 15, 245.
    摘要:Berlinck, R. G. S.; Kossuga, M. H.; Nascimento, A. M., Science of Synthesis, (2005) 18, 1087.
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