CAS: 148411-57-8; (2R,3S,4R,5R,6S)-5-Amino-6-[(2R,3S,4R,5R,6R)-5-Amino-4,6-Dihydroxy-2-(Hydroxymethyl)Oxan-3-Yl]Oxy-2-(Hydroxymethyl)Oxane-3,4-Diol

专利信息

专利号:US-5856143-A
优先权日:1993-05-14
标 题 :N-containing saccharides and method for the synthesis of N-containing saccharides from amino-deoxy-disaccharides and amino-deoxy-oligosaccharides
发明人：NILSSON KURT G I
权利人:BIOFLEXIN AB
摘要:Synthesis of an amino-disaccharide, amino-oligosaccharide or a derivative thereof, characterized in that a monosaccharide, a disaccharide, an oligosaccharide, a glycoside or a derivative thereof, in the presence of a glycosidase as catalyst, is reacted with an amino-deoxy-saccharide or a derivative thereof, and that the amino-saccharide is isolated from the product mixture directly or after chemical/enzymatic modification.

专利号:WO-0012747-A1
优先权日:1998-08-31
标 题 :Method for enzymatic synthesis of glycosides, disaccharides, and oligosaccharides
发明人：NILSSON KURT
权利人:NILSSON KURT
摘要:The present invention describes a method for enzymatic synthesis of glucosides, disaccharides, oligosaccharides, modified disaccharides and oligosaccharides, preferably of the kind found in glycoproteins and especially of Lacto-N-tetraose (LNT) and of Lacto-N-neotetraose (LNnT).

专利号:US-12378589-B2
优先权日:2016-12-27
标 题 :In vivo synthesis of sialylated compounds
发明人：BEAUPREZ JOERI; COUSSEMENT PIETER; VAN HERPE DRIES; PETERS GERT; VERCAUTEREN ANNELIES
权利人:INBIOSE NV
摘要:This disclosure is in the technical field of synthetic biology and metabolic engineering. More particularly, this disclosure is in the technical field of fermentation of metabolically engineered microorganisms. This disclosure describes engineered micro-organisms able to synthesize sialylated compounds via an intracellular biosynthesis route. These micro-organisms can dephosphorylate N-acetylglucosamine-6-phosphate to N-acetyl glucosamine and convert the N-acetylglucosamine to N-acetylmannosamine. These micro-organisms also have the ability to convert N-acetylmannosamine to N-acetyl-neuraminate. Furthermore, this disclosure provides a method for the large scale in vivo synthesis of sialylated compounds, by culturing a microorganism in a culture medium, optionally comprising an exogenous precursor such as, but not limited to lactose, lactoNbiose, N-acetyllactosamine and/or an aglycon, wherein the microorganism intracellularly dephosphorylates N-acetylglucosamine-6-phosphate to N-acetylglucosamine, converts N-acetyl-glucosamine to N-acetylmannosamine and convert the latter further to N-acetyl-neuraminate.

专利号:US-6183994-B1
优先权日:1993-05-14
标题:N-containing saccharides and method for the synthesis of N-containing saccharides from amino-deoxy-disaccharides and amino-deoxy-oligosaccharides
发明人：NILSSON KURT G I
权利人:BIOFLEXIN AB
摘要:Synthesis of an amino-disaccharide, amino-oligosaccharide or a derivative thereof, characterized in that a monosaccharide, a disaccharide, an oligosaccharide, a glycoside or a derivative thereof, in the presence of a glycosidase as catalyst, is reacted with an amino-deoxy-saccharide or a glycoside or derivative thereof, and that the amino-saccharide is optionally isolated from the product mixture directly or after chemical/enzymatic modification.

专利号:US-2023278976-A1
优先权日:2021-07-05
标题:Synthesis Of Beta-Glycolipid Compounds
发明人：BOXLEY CHETT; STOLLEY RYAN; BRUGGEMAN ROBERT
权利人:GLYCOSURF INC
摘要:Methods of forming a glycolipid are disclosed. A method may include glycosylating a sugar with a beta-hydroxyester using BF3-L as a glycosylation promoter. L may include one or more of Diethylether, Tetrahydrofurn, Dimethyle Sulfide, or combinations thereof. The beta-hydroxyester may include a carbon length ranging from C2 to C24. The sugar may be a protected sugar that includes peracetylated-rhamnose, peracetylated-xylose, peracetylated-glucose, peracetylated-galactose or combinations thereof. The beta-hydroxyester and sugar may be combined in a reaction vessel to form a mixture. A solvent may be added to the mixture to substantially dissolve the mixture. The glycosylation promoter may be added to the solution such that the solution is maintained withing a desired temperature range.

专利号:WO-9318787-A1
优先权日:1992-03-25
标 题 :Trans-sialidase and methods of use and making thereof
发明人：NUSSENZWEIG VICTOR; SCHENKMAN SERGIO; EICHINGER DAN; VANDEKERCKHOVE FLIP
权利人:UNIV NEW YORK
摘要:Polypeptides are provided having trans-sialidase enzymatic activity in substantially pure form, nucleic acids coding therefor, antibodies specific for such polypeptides, processes for producing the enzyme and methods of use of the enzyme, in particular for the synthesis of sialyl α(2â†?3)-linked saccharides, glycoproteins and glycolipids. Such enzymes are isolatable as nucleic acid or amino acid sequences from parasites of the genus Trypanosoma.