CAS: 1508-75-4; N-Ethyl-3-Hydroxy-2-Phenyl-N-(Pyridin-4-Ylmethyl)Propanamide

上下游产品

CAS号33403-97-3 N-(4-吡啶甲基)乙胺 | CAS号14510-37-3 乙酰托品酰氯 | CAS号492-38-6 2-苯基丙烯酸 | CAS号529-64-6 托品酸 | CAS号57322-50-6 N-乙基-N-(4-吡啶甲基)阿托胺 | CAS号33403-97-3 N-(4-吡啶甲基)乙胺

N-Ethyl-N-(4-Pyridylmethyl)-α-Methylethyl-Phenylacetamide置于盐酸体系中,用 水 用作溶剂,以95%的收率获得托吡卡胺
参考文献:一种托吡卡胺的制备方法
标题:一种托吡卡胺的制备方法
摘要:本发明涉及一种托吡卡胺的制备方法,所述方法步骤如下:(1)将3‑羟基‑2‑苯基丙酸,甲苯投入到烧杯中搅拌均匀氮气置换后保护,加热回流,不溶;反应分别加入三乙胺和乙酰氯,加热回流至溶清,降至室温,滴加氯化亚砜,继续反应,减压浓缩干得到2‑氯羰基‑2‑苯基乙酯;(2)准备另一夹套瓶,加入乙基吡啶‑4‑基甲胺,三乙胺和甲苯,氮气置换后保护,冷却,缓慢滴加2‑氯羰基‑2‑苯基乙酯溶于甲苯的溶液.滴毕,继续反应;(3)上述反应完全后滴加水,分液萃取,盐水洗涤,甲苯层加入3N盐酸溶液水解,冷至室温,分液,分离得到水相,水相乙酸乙酯洗涤;(4)降温,滴加饱和碳酸氢钠水溶液调节ph,乙酸乙酯萃取,有机相浓缩得淡黄色油状物;(5)油状物粗品用乙酸乙酯溶解,缓慢滴加庚烷,析晶,抽滤洗涤得到目标产物托吡卡胺.

专利信息

专利号:US-9650407-B2
优先权日:2011-11-02
标 题 :Reprogramming of cellular adhesion
发明人：GARTNER ZEV JORDAN; SELDEN NICHOLAS SCOTT; TODHUNTER MICHAEL E; LIANG SAMANTHA ISABEL; WEBER ROBERT JOSEPH; JEE NOEL YOUNGHO; LIU JENNIFER S
权利人:UNIV CALIFORNIA
摘要:Disclosed are membrane-anchored polynucleotides, and compositions comprising the membrane-anchored polynucleotides. Also disclosed are the processes for the synthesis of these compounds, compositions comprising such compounds, and the use of such compounds and compositions in research and therapeutic applications.

专利号:US-9359376-B2
优先权日:2011-04-08
标题:Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; HOLLINGER FRANK PETER
权利人:DUGAR SUNDEEP; MAHAJAN DINESH; HOLLINGER FRANK PETER; SPHAERA PHARMA PTE LTD
摘要:The present invention relates to the synthesis and application of novel chiral/achiral substituted methyl formyl reagents to modify pharmaceutical agents and/or biologically active substances to modify the physicochemical, biological and/or pharmacokinetic properties of the resulting compounds from the unmodified original agent.

专利号:US-2023271983-A1
优先权日:2020-07-29
标题 :Functionalized isonitriles and products, preparation and uses thereof
发明人：SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

专利号:EP-1930323-A1
优先权日:2004-03-11
标 题:Biphenyl compounds useful in the synthesis of muscarinic receptor antagonists

专利号:CN-1733704-A
优先权日:2004-08-09
标题:Synthesis of betaine salicylate and its biological and pharmacological effects

专利号:US-11369657-B2
优先权日:2011-12-19
标 题:Small molecule polypeptide for preventing and restraining inflammation and application of same
发明人：XU XUN; XU YAN; SUN QIAO
权利人:SHANGHAI FIRST PEOPLES HOSPITAL; XU XUN; XU YAN
摘要:The present invention provides a polypeptide that is rich in leucine and used for preventing and restraining inflammation, and an application of same. The present invention further provides a method for preparing the polypeptide and a pharmaceutical composition containing the polypeptide. The advantage of the polypeptide comprises: small molecular weight, so as to permeate various eye tissue barriers; high water solubility, so as to have high dissolubility in neutral tears, aqueous humor and vitreous humor; and simple synthesis, so as to have a low preparation cost.