CAS: 1700-37-4; 3-Benzyloxybenzaldehyde

该化合物是一种多用途芳香甲醚,其特点是,在苯甲醚环的元体位置上存在一种苯基替代物.该化合物广泛用作有机合成的中间体,特别是在制药,农用化学品和精细化学品方面.其受苯基保护的苯丙胺组增强了稳定性,同时允许有选择地去保护进一步功能化.藻类系是凝聚,减少或核分裂性添加反应的主要反应场所.该化合物在普通有机溶剂中表现出良好的溶解性,便于其在多步骤合成路线中使用.其定义明确的结构和再活动使得它成为在研究和工业应用中建造复杂的分子结构的宝贵建筑.

结构式图片

相似化合物

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欧盟法规

ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

    N-[(3-Phenylmethoxyphenyl)Methylideneamino]Aniline置于水,Phosphorus Pentoxide体系中,化学反应 0.01H,以72%的收率获得3-苄氧基苯甲醛
    参考文献:Banerjee,Krishna; Mitra,Alok Kumar,Journal Of The Indian Chemical Society,2003,Vol. 80,# 3,P. 184-186
    标题:Banerjee,Krishna; Mitra,Alok Kumar,Journal Of The Indian Chemical Society,2003,Vol. 80,# 3,P. 184-186

    海关参考信息

    专利信息


    专利号:US-5861532-A
    优先权日:1997-03-04
    标 题:Solid-phase synthesis of N-alkyl amides
    发明人:BROWN EDWARD G; NUSS JOHN M
    权利人:CHIRON CORP
    摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

    专利号:US-9611206-B2
    优先权日:2011-03-02
    标题:Synthesis of intermediate for treprostinil production
    发明人:SHARMA VIJAY
    权利人:UNITED THERAPEUTICS CORP
    摘要:The compound according to Formula I is an intermediate in the synthesis of prostacylin analogs. The present invention provides an efficient method for synthesizing a Formula I compound.

    专利号:US-5175302-A
    优先权日:1987-07-13
    标 题 :Nucleophilic fluoroalkylation of aldehydes
    发明人:STAHLY G PATRICK
    权利人:ETHYL CORP
    摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

    专利号:US-6482950-B1
    优先权日:1991-05-06
    标 题 :Squarylium compounds, and processes and intermediates for the synthesis of these compounds
    发明人:GARCIA PAULINA P; LEE JOHN W; MARSHALL JOHN L; MCGOWAN DONALD A; PUTTICK ANTHONY J; SPENCER THOMAS K; STROUD STEPHEN G; TELFER STEPHEN J; ZURAW MICHAEL J
    权利人:POLAROID CORP
    摘要:Squarylium compounds of the formula: n wherein Q 1 and Q 2 are each independently a pyrylium, thiopyrylium, selenopyrylium, benzpyrylium, benzthiopyrylium or benzselenopyrylium nucleus, and R 1 and R 2 are each independently an aliphatic or cycloaliphatic group, can be prepared by reacting a squaric acid derivative of the formula: n with a compound of the formula Q 2 CH 2 R 2 in the presence of a base. The derivatives of Formula II may be prepared by condensing a 2,3,4,4-tetrahalocyclobut-2-en-1-one with a compound of the formula Q 1 CH 2 R 1 in the presence of a base to produce a compound of the formula: n wherein Q 1 and R 1 are as defined above, and X represents chlorine or bromine, and hydrolyzing the compound of Formula III. Alternatively, the derivatives of Formula II may be prepared by reacting a diester, monoacid chloride monoester or diacid chloride of squaric acid with a compound of the formula Q 1 CH 2 R 1 in the presence of a base, followed by hydrolysis of the resultant monoacid chloride or monoester derivative of the compound of Formula II to the parent compound.

    专利号:US-4837327-A
    优先权日:1987-07-13
    标 题 :Process for nucleophilic fluoroalkylation of aldehydes
    发明人:STAHLY G PATRICK
    权利人:ETHYL CORP
    摘要:Aryl difluoromethyl sulfone adds to alkehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

    专利号:US-4999429-A
    优先权日:1989-01-09
    标 题 :Process for the preparation of α,α,β-1-trifluoro-1-olefinic derivatives
    发明人:STAHLY G PATRICK
    权利人:ETHYL CORP
    摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.
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    合成参考文献


    摘要:Wang, H.-Y.; Zhao, G., Science of Synthesis, (2019) , 232.
    参考文献:10.1007/s002030050782
    摘要:Müller JA, Galushko AS, Kappler A, Schink B. Anaerobic degradation of m-cresol by Desulfobacterium cetonicum is initiated by formation of 3-hydroxybenzylsuccinate. Arch Microbiol. 1999 Nov;172(5):287–94. doi: 10.1007/s002030050782.
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