CAS: 22715-27-1; 2,5-Diaminepyrimidine

该化合物是一种七环有机化合物,其2和5个位置上以矿物质组取代了火药核心,这种结构在合成应用中具有多功能性,特别是作为制药,农用化学品和材料科学的一个构件,其双重性能可以有选择性地进行反应,有助于形成复杂的分子结构.该化合物因其在核分子类比和作为包括抗病毒剂和抗癌剂在内的生物活性分子合成的前体的作用而备受重视.高纯度能确保研究和工业过程的一贯性能.其稳定性和明确界定的再活动特征使得它成为专门的化学合成的可靠中间体.

结构式图片

相似化合物

1098605-67-4 3073-77-6 109-12-6

欧盟法规

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上下游产品

CAS号3073-77-6 2-氨基-5-硝基嘧啶 | CAS号59690-85-6 N-(5-氨基-嘧啶-2-基)-乙酰胺 | CAS号925896-84-0 N-(2-氨基-5-嘧啶)-2... | CAS号554-68-7 三乙胺盐酸盐

合成工艺路线路线简述

    5-Phenylazo-Pyrimidin-2-Ylamine置于1,4-二氧六环,镍体系中,化学反应生成2,5-二氨基嘧啶
    参考文献:Hensel,Festschr. C. Wurster S. 135,139
    标题:Hensel,Festschr. C. Wurster S. 135,139

    专利信息


    专利号:US-2022356182-A1
    优先权日:2009-03-27
    标题 :Inhibitors of hepatitis c virus replication
    发明人:COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
    权利人:MERCK SHARP & DOHME
    摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

    专利号:US-11053243-B2
    优先权日:2009-03-27
    标 题:Inhibitors of hepatitis C virus replication
    发明人:COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
    权利人:MERCK SHARP & DOHME
    摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

    专利号:US-9090661-B2
    优先权日:2009-03-27
    标 题:Inhibitors of hepatitis C virus replication
    发明人:COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN
    权利人:MERCK SHARP & DOHME
    摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

    专利号:JP-2000281611-A
    优先权日:1999-03-30
    标 题 :Synthesis of phenolic compound having protected hydroxy group, and radioactive ray-sensitive composition by using the same

    专利号:CN-117050024-B
    优先权日:2023-10-13
    标题:A kind of synthesis method of 2-amino-4,6-dichloro-5-carboxamidopyrimidine

    专利号:CN-117050024-A
    优先权日:2023-10-13
    标 题:A kind of synthesis method of 2-amino-4,6-dichloro-5-carboxamidopyrimidine
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    主要参考文献

    参考标题: Inhibitors Of Hepatitis C Virus Replication Inhibiteurs De La Réplication Du Virus De L'Hépatite C
    摘要:The Present Invention Relates To Compounds Of Formula (I) That Are Useful As Hepatitis C Virus (Hcv) Ns5A Inhibitors, The Synthesis Of Such Compounds, And The Use Of Such Compounds For Inhibiting Hcv Ns5A Activity, For Treating Or Preventing Hcv Infections And For Inhibiting Hcv Viral Replication And/or Viral Production In A Cell-Based System.

    合成参考文献


    摘要:D. J. Brown and J. Harper. J. Chem. Soc. 1963, 1276.
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