异丁酸置于磷化氢,溴体系中,化学反应生成2-溴代异丁酸甲酯 参考文献:Saunders; Stacey,Journal Of The Chemical Society,1948,P. 1777 标题:Saunders; Stacey,Journal Of The Chemical Society,1948,P. 1777
专利号:US-4288608-A 优先权日:1978-06-01 标题:Synthesis of anthracyclines 发明人:JOHNSON FRANCIS; KIM KYOUNG S 权利人:RESEARCH CORP 摘要:There is provided a novel method of synthesizing certain heterocyclic quinones. In particular there is provided a novel and regiospecific synthesis of 9-acetyl-6,11-dihydroxy-4-methoxy-7,8,9,10-tetrahydronaphthacene-5,12-quinone (7,9-dideoxydaunomycinone) which is known intermediate in the synthesis of daunomycinone. There is also provided a method of preparing analogs of 7,9-dideoxydaunomycinone which thus provide for the preparation of known and desired analogs of daunomycinone. Daunomycinone is a known compound which is an intermediate in the preparation of the clinically accepted naturally-occurring antitumor antibiotics daunomycin and its derivitive adriamycin.
专利号:US-2003144441-A1 优先权日:2001-11-13 标题 :Controlled copolymerization of methyl acrylate with olefins under mild conditions 发明人:SEN AYUSMAN; ELYASHIV-BARAD SHARON; LIU SHENGSHENG 摘要:A copper-mediated process for the synthesis of random copolymers of methyl acrylate with non-polarolefins, ranging from ethene to 1-octene, norbornene and norbornene derivatives, and capable of synthesizing copolymers having greater than 5% incorporation of the olefin, as well as copolymers synthesized using the process are described. The process displays many of the characteristics of a living polymerization process: the polydispersities of the copolymers obtained are less than about 1.7, preferably from about 1.1 to about 1.4, and it is possible to synthesize novel block terpolymers of methyl acrylate with olefins by the sequential addition of the latter monomers.
专利号:US-9777082-B2 优先权日:2011-10-05 标题 :Synthesis of hyperbranched polyacrylates by emulsion polymerizsation of inimers 发明人:PUGH COLEEN; GARCIA GUILLERMINA 权利人:UNIV AKRON 摘要:A method for the production of hyperbranched polyacrylates includes the step of reacting acrylic inimers through controlled living polymerization in aqueous conditions. The inimers may have the formula: n nWherein X is a halogen, a thiocarbonylthio or nitroxide group, and R is hydrogen, methyl, dodecyl, and groups containing mesogenin substituents, fluorocarbon substituents, siloxane substituents and oxyethylene substituents. In particular, the aqueous condition is emulsion or miniemulsion. The polymerization may be reverse ATRP, SN&RI and AGET polymerization or RAFT polymerization (with thiocarbonylthio X groups) or nitroxide mediated polyeization (with nitroxide X groups).
专利号:US-11834442-B2 优先权日:2019-09-11 标题 :Mechanical regulation of photoswitching 发明人:ROBB MAXWELL J; HU XIAORAN 权利人:CALIFORNIA INST OF TECHN 摘要:A mechanochemically-gated photoswitching molecular system is described, along with the methods for the synthesis and use thereof. This molecular system comprises a thermally stable diarylethene-dienophile Diels-Alder adduct mechanophore embedded into a polymer chain or network, wherein the mechanophore undergoes the retro [4+2] cycloaddition reaction under mechanical force to reveal a diarylethene photoswitch.
专利号:US-6313342-B1 优先权日:1994-08-19 标题 :Synthesis of esters of mercaptocarboxylic acids 发明人:LABAT YVES; MULLER JEAN-PIERRE 权利人:ATOCHEM ELF SA 摘要:Esters of formula:in which X denotes a C1-C4 alkylene radical and R a C1-C18 alkyl radical, are prepared by reaction of a hydrosulphide with the corresponding halocarboxylic ester:where Y denotes a chlorine or bromine atom. The reaction is performed under a hydrogen sulphide pressure of at least 10 bars absolute, and preferably in an anhydrous or substantially anhydrous alcoholic medium.
专利号:US-9434823-B2 优先权日:2011-10-18 标题 :Diene copolymer including at least two blocks, method for synthesizing same and rubber composition containing same 发明人:MATMOUR RACHID; SEEBOTH NICOLAS 权利人:MICHELIN & CIE; MICHELIN RECH TECH; MICHELIN & CIE; MICHELIN RECH TECH 摘要:A process for the synthesis of a diene copolymer comprising at least two blocks, at least one of the blocks being composed of a diene elastomer, characterized in that it comprises a stage of 1,3-dipolar reaction of two polymers defined as being:n a) a diene elastomer bearing an alkyne functional group at one or each of its chain ends, and b) a polymer bearing at least one azide functional group. nn This process of synthesis can be adjusted, whatever the nature of the monomers necessary to form each of the blocks of the copolymer. Each block can be synthesized with an appropriate chemistry, independently of the other block.