CAS: 30379-55-6; 2-(Benzyloxy)Acetic Acid

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CAS号79-11-8 氯乙酸 | CAS号100-51-6 苯甲醇 | CAS号79-08-3 溴乙酸 | CAS号30379-54-5 2-(苄氧基)乙酸苄酯 | CAS号32122-09-1 苄氧基乙酸乙酯 | CAS号124-38-9 二氧化碳 | CAS号66222-28-4 tributyl(phenyl... | CAS号3926-62-3 氯乙酸钠 | CAS号20194-18-7 苯甲醇钠 | CAS号32122-09-1 苄氧基乙酸乙酯 | CAS号144192-68-7 S-phenyl 2-phen... | CAS号92-92-2 4-苯基苯甲酸 | CAS号236110-81-9 (S)-(+)-4-Benzy... | CAS号30379-54-5 2-(苄氧基)乙酸苄酯 | CAS号622-08-2 2-苄氧基乙醇 | CAS号102629-92-5 2-hydroxy-3-phe... | CAS号6940-78-9 1-溴-4-氯丁烷 | CAS号60656-87-3 苄氧基乙醛 | CAS号622-22-0 乙二醇二苄醚

2-苄氧基乙醇置于1-羟基环己基苯基甲酮,Sodium Hydroxide体系中,用 乙二醇二甲醚 作为反应溶剂,以85%的收率获得产物苄氧乙酸
参考文献:通过氢原子转移将伯醇和醛氧化成羧酸
标题:通过氢原子转移将伯醇和醛氧化成羧酸
摘要:伯醇和伯醛氧化成相应的羧酸是有机合成中的基本反应.在本文中,我们报告了一种用于氧化伯醇和醛的新化学选择性工艺.这种无金属反应具有新的氧化剂,易于操作的程序,高分离产率以及即使在易受攻击的仲醇和叔丁烷亚磺酰胺存在下也具有非常好至优异的官能团耐受性的特点.
DOI:10.1021/acs.Orglett.1C02188

专利信息

专利号:US-8809526-B2
优先权日:2010-07-19
标题 :Synthesis of cyclopentaquinazolines
发明人：KERSCHEN JAMES ALAN; BRIDGES ALEXANDER JAMES; DALZIEL SEAN MARK; DAPREMONT Olivier; KIM HYUNJUNG; THOMPSON ANDREW S; ZELLER JAMES ROBERT
权利人:KERSCHEN JAMES ALAN; BRIDGES ALEXANDER JAMES; DALZIEL SEAN MARK; DAPREMONT Olivier; KIM HYUNJUNG; THOMPSON ANDREW S; ZELLER JAMES ROBERT; ONYX PHARMA INC
摘要:A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N—{N-{4-[N-((6S)-2 -hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-N-(prop-2 -ynyl)amino]benzoyl}-L-γ-glutamyl}-D-glutamic acid (ONX-0801).

专利号:US-5399721-A
优先权日:1990-01-12
标题:Synthesis of optically pure 4-aryl-2-hydroxytetronic acids
发明人：HOPPER ALLEN T; WITIAK DONALD T
权利人:UNIV OHIO STATE RES FOUND
摘要:The present invention relates to a method for synthesis of optically pure stereogenically labile 4-aryl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase. the invention further relates to the pharmaceutical use of such compounds in the treatment of coronary artery diseases, especially in the treatment and/or prevention of atherosclerosis.

专利号:US-5656662-A
优先权日:1990-01-12
标 题:Synthesis of optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids
发明人：MANTRI PADMAJA; WITIAK DONALD T
权利人:UNIV OHIO STATE RES FOUND
摘要:The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase, thus making them useful in the treatment of coronary artery diseases, especially atherosclerosis, and additionally, as inhibitors of various inflammatory cytokines, making them useful in the treatment of both acute and chronic inflammation, as well in the treatment of cachexia, rheumatoid arthritis, multiple sclerosis, Crohn's disease and ulcerative colitis. The invention further relates to pharmaceutical compositions of the instant compounds.

专利号:US-4171439-A
优先权日:1975-04-11
标 题 :Antibacterial analogs of isocephalosporins
发明人：CONWAY TERRY T; LIM GARY M F; MENARD MARCEL
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein Z is halo or hydroxyl and X is acylamino. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.

专利号:US-9346853-B2
优先权日:2012-06-20
标 题 :Synthesis of telaprevir and boceprevir, or pharmaceutically acceptable salts or solvates as well as intermediate products thereof including β-amino acids prepared via Mukaiyama aldol addition
发明人：HOEFERL-PRANTZ KATHRIN; FELZMANN WOLFGANG; WILHELM THORSTEN; BENITO-GARAGORRI DAVID
权利人:SANDOZ AG
摘要:The invention relates to synthetic routes for preparing telaprevir and boceprevir, and its intermediates as well as peptides other than telaprevir. The synthetic routes are based on a Mukaiyama aldol addition reaction of a silyl enol ether or an enolate with an imine. The invention also refers to novel intermediates for preparing telaprevir/boceprevir or other peptides.

专利号:WO-2024220193-A1
优先权日:2023-04-21
标题 :Methods for preparing (-)-epicatechin
发明人：PAIS GODWIN
权利人:MARS INC
摘要:Methods steps for the synthesis of (-)-epicatechin are provided herein. The synthetic methods are provided in two phases: (1) synthesis of epoxide intermediates and (2) synthesis of (-)-epicatechin.