CAS: 32046-62-1; 5-Bromo-1H-Benzotriazole

该化合物是属于苯甲胺等级的有机化合物,以其在各个领域的应用而著称,包括制药和材料科学,该化合物的特点是在苯三氮酸盐环的5个位置上替换的溴原子,这增强了其在有机溶剂中的再活性和溶性,典型的似乎是白色到浅黄色晶状固体,其特点是它能够作为紫外线吸收器,使其在保护材料免受光降解方面有用.此外,5-溴三硝酸盐的展示特性使其能作为腐蚀抑制剂和聚合化学中的混合剂发挥作用,其分子结构有助于其稳定性和再活性,使它成为有机合成中有价值的中间体.安全数据表明,应当谨慎地处理,因为它在接触时可能会对健康造成危害.

英文名称5-Bromo-1H-Benzotriazole
中文名称5-溴-1H-苯并三氮唑
IUPAC名称5-bromo-2H-benzo[d][1,2,3]triazole
其它别名5-溴-1H-1,2,3-苯并三唑; 6-Bromo-1H-1,2,3-Benzotriazole
CAS编号32046-62-1
MFCD编号:MFCD00464510
EINECS号:813-000-8
分子式:C6H4BrN3
分子量:198.02
产品CID: 1310564
产品分类有机原料→分子砌块→芳杂环类化合物→其它芳杂环类化合物

相似结构搜索
InChIKey: BQCIJWPKDPZNHD-UHFFFAOYSA-N
InChI=1S/C6H4BrN3/c7-4-1-2-5-6(3-4)9-10-8-5/h1-3H,(H,8,9,10)…
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数0.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P264-P270-P330-P501
危险等级IRRITANT
危险品标志Xn
安全声明H303+H313+H333
危险类别码22
WGK Germany3

欧盟法规

C&L通报

上下游产品

6-Bromo-1H-Benzo[d][1,2,3]Triazol-1-Ol 18355-04-9

合成工艺路线路线简述

合成目标产物 5-Bromo-1H-Benzotriazole 主要起始原料 4-Bromo-2-Nitroaniline
(文献来源)合成步骤主要原料 4-Bromo-2-Nitroaniline

4-溴-2-硝基苯胺置于三氯化铁,溶剂黄146,肼,Sodium Nitrite体系中,用甲醇作为反应溶剂,化学反应 6.0H,反应生成 5-溴-1H-苯并噻唑
参考文献:2-Arylindoles As Gonadotropin Releasing Hormone (Gnrh) Antagonists: Optimization Of The Tryptamine Side Chain
标题:2-Arylindoles As Gonadotropin Releasing Hormone (Gnrh) Antagonists: Optimization Of The Tryptamine Side Chain
摘要:A Series Of 2-Arylindoles Containing Novel Heteroaromatic Substituents On The Tryptamine Tether,Based On Compound 1,Was Prepared And Evaluated For Their Ability To Act As Gonadotropin Releasing Hormone (Gnrh) Antagonists. Successful Modifications Of 1 Included Chain Length Variation (Reduction) And Replacement Of The Pyridine With Heteroaromatic Groups. These Alterations Culminated In The Discovery Of Compound 27Kk Which Had Excellent In Vitro Potency And Oral Efficacy In Rodents. (C) 2002 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0960-894X(02)00026-4

专利信息

专利号:US-10995078-B2
优先权日:2013-03-13
标题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:CN-111235597-A
优先权日:2019-09-26
标题 :Synthesis method of nitroazole energetic compound