[(3-甲基-2-丁烯-1-基)氧基]苯置于盐酸,2-Chloro-2-Methyl-Butene-(3)体系中,化学反应生成 1-氯-3-甲基-2-丁烯 参考文献:Prevalence Of Rheumatic Fever And Rheumatic Heart Disease In Yemen 标题:Prevalence Of Rheumatic Fever And Rheumatic Heart Disease In Yemen 摘要:这项研究的主要目的是确定也门风湿性心脏病的患病率.在1997年10月至1998年3月期间,对5000名年龄在5至18岁之间的学童(2504名女性和2496名男性)进行了一项前瞻性集群抽样筛查研究.疑似病例接受了心电图,胸部x光和多普勒超声心动图检查.尽管未发现活动性风湿热病例,但有12名女孩和6名男孩患有该疾病,患病率为每千人3.6例,高于邻国的报道.所有确诊和疑似病例每3周按体重给予苄青霉素g,先进行试验剂量.风湿热的预防计划,以及预防链球菌喉部感染,是未来的目标. DOI:10.1177/021849230100900111
专利号:US-11912654-B2 优先权日:2021-09-03 标 题:Process for stereospecific synthesis of vitamin K2 and its novel intermediates 发明人:MEHTA DILIP; SHASHTRI MAYANK; RAJU BNS; SHAH ASHWIN; VORA PARIN; MAHALE UMAKANT 权利人:SYNERGIA LIFE SCIENCES PVT LTD 摘要:The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7. The present disclosure further discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.
专利号:WO-2023031841-A1 优先权日:2021-09-03 标题:A process for the stereospecific synthesis of vitamin k2 and its intermediates 发明人:MEHTA DILIP; SHASHTRI MAYANK; RAJU BNS; VORA PARIN; MAHALE UMAKANT 权利人:SYNERGIA LIFE SCIENCES PVT LTD 摘要:The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7, in particular. It also discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.
专利号:WO-2024013633-A1 优先权日:2022-07-11 标 题 :Process for the synthesis of vitamin k2 发明人:SHASTRI MAYANK; BAIKAR MRUNALI H; VORA PARIN K; BNS RAJU 权利人:SYNERGIA LIFE SCIENCES PVT LTD 摘要:The present disclosure relates to the synthesis of Vitamin K2 bearing varying prenyl side chains. The synthesis comprises the reaction of phenyl sulfone of tert-butyl dimethyl silyl (TBDMS) protected mono prenyl menadiol with prenyl halides bearing varying prenyl units in the presence of the phase transfer catalyst followed by reductive desulphonation to yield TBDMS ether of Vitamin K2. The TBDMS ether is then oxidized in the presence of chromium trioxide and periodic acid to yield the corresponding Vitamin K2.
专利号:US-2007260076-A1 优先权日:2003-12-05 标 题:Practical, Cost-Effective Synthesis of Ubiquinones 发明人:LIPSHUTZ BRUCE H; BERL VOLKER; SHEIN KARIN; WETTERICH FRANK 权利人:LIPSHUTZ BRUCE H; BERL VOLKER; SHEIN KARIN; WETTERICH FRANK 摘要:The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention. The invention further provides an improved method for the carboalumination of alkyne substrates.
专利号:US-2006167289-A1 优先权日:2003-12-05 标题 :Practical, cost-effective synthesis of ubiquinones 发明人:LIPSHUTZ BRUCE H; BERL VOLKER; SCHEIN KARIN; WETTERICH FRANK 权利人:ZYMES LLC 摘要:The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention. The invention further provides an improved method for the carboalumination of alkyne substrates.
专利号:US-4067906-A 优先权日:1976-08-03 标题 :Novel process for the synthesis of tricyclo[6.2.2.03,8 ]dodecane derivatives 发明人:TAVARES ROBERT F; KATTEN ELLIOT 权利人:GIVAUDAN CORP 摘要:A novel process for the preparation of tricyclo[6.2.2.0 3 ,8 ]dodecane derivatives is presented. This novel process is applied to the synthesis of the odorant 4-acetyl-1,7,7-trimethyltricyclo[6.2.2.0 3 ,8 ]-3-dodecene, also known as 4-aceto-6,8a-ethano-1,1,6-trimethyl-1,2,3,5,6,7,8,8a-octahydronaphthalene.
参考文献:10.1515/znc-2005-9-1019 摘要:Wood WF, Walsh A, Seyjagat J, Weldon PJ. Volatile compounds in shoulder gland secretions of male flying foxes, genus Pteropus (Pteropodidae, Chiroptera). Z Naturforsch C J Biosci. 2005 Sep;60(9-10):779–84. doi: 10.1515/znc-2005-9-1019.