CAS: 5867-45-8; N-(Pyridin-3-yl)Acetamide

该化合物是一种有机化合物,其特征为氨化功能组和环.该化合物的特征为三点方位与乙酰胺组的替代物,该物质具有化学特性.该化合物一般是白色的白色,可以脱白固体,可溶于极地溶解剂,如水和酒精,因为存在可进行氢结合的氨基组.N-(丙烯-3-yl)乙酰胺可能展示生物活动,使其对药用化学和药物开发具有兴趣.其结构允许与生物目标进行可能的相互作用,可以用于治疗用途.该化合物的稳定性和再活性可以受到基环和乙酰胺组的电子效应的影响,使其在有机合成中成为多用途的建筑块.与许多有机化合物一样,应当遵守适当的处理和安全防范措施,因为潜在的毒性或再活性.

英文名称N-(Pyridin-3-yl)Acetamide
中文名称N-(吡啶-3-基)乙酰胺
IUPAC名称N-(pyridin-3-yl)acetamide
其它别名3-乙酰氨基吡啶; 3-Acetamidopyridine
CAS编号5867-45-8
MFCD编号:MFCD00234323
EINECS号:675-416-4
FDA UNII编号:862W2J86S3
分子式:C7H8N2O
分子量:136.15
产品CID: 1561756
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: JVYIBLHBCPSTKF-UHFFFAOYSA-N
InChI=1S/C7H8N2O/c1-6(10)9-7-3-2-4-8-5-7/h2-5H,1H3,(H,9,10)…
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数1.0

相似化合物

29958-15-4 70298-88-3 14815-19-1

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
严重眼刺激类别2
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P260-P264-P270-P330-P405-P501

欧盟法规

C&L通报

上下游产品

合成工艺路线路线简述

3-Acetamidopyridine N-Oxide置于1,1'-Bis(Diphenylphosphino)Ferrocene,Palladium Diacetate,三乙胺体系中,用乙腈作为反应溶剂,化学反应 1.0H,以64%的收率获得产物3-乙酰氨基吡啶
参考文献:通过钯催化的三烷基胺转移氧化对吡啶 N-氧化物进行脱氧
标题:通过钯催化的三烷基胺转移氧化对吡啶 N-氧化物进行脱氧
摘要:描述了一种方便的化学选择性方法,用于通过转移氧化由 [pd(Oac) 2]/dppf 催化的三乙胺转移氧化吡啶 N-氧化物衍生物.
DOI:10.1055/s-0028-1083508

海关参考信息

2912110000-甲醛
2912120000-乙醛
2933310010-吡啶
2924199090-其他无环酰胺
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-8188282-B2
优先权日:2006-07-15
标题:Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS; SANOFI AVENTIS
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.

专利号:US-8309716-B2
优先权日:2005-07-29
标题 :Pyrrolo[2,3-d]pyrimidine derivatives: their intermediates and synthesis
发明人：RUGGERI SALLY GUT; HAWKINS JOEL M; MAKOWSKI TERESA M; RUTHERFORD JENNIFER L; URBAN FRANK J
权利人:RUGGERI SALLY GUT; HAWKINS JOEL M; MAKOWSKI TERESA M; RUTHERFORD JENNIFER L; URBAN FRANK J; PFIZER
摘要:This invention relates to methods and intermediates useful for the synthesis of pyrrolo[2,3-d]pyrimidine compounds. Specifically novel synthetic methods and intermediates for the synthesis of 3-{(3R,4R)-4-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino}-piperidin-1-yl)-3-oxo-propionitrile and its corresponding citrate salt are disclosed.

专利号:CA-2657717-A1
优先权日:2006-07-15
标题 :A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:CN-101490014-B
优先权日:2006-07-15
标题:Regioselective palladium-catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:CN-101490014-A
优先权日:2006-07-15
标题:Regioselective palladium-catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:EP-2044033-B1
优先权日:2006-07-15
标题:A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles