CAS: 60282-87-3; (8R,9S,10R,13S,14S,17R)-13-Ethyl-17-Ethynyl-17-Hydroxy-1,2,6,7,8,9,10,11,12,13,14,17-Dodecahydro-3H-Cyclopenta[a]Phenanthren-3-One

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CAS号1323980-05-7 3-ethoxy-18-met... | CAS号4301-14-8 乙炔基溴化镁 | CAS号74-96-4 溴乙烷 | CAS号74-86-2 乙炔 | CAS号74177-02-9 17α-Ethinyl-3,3... | CAS号21800-83-9 18-甲基-4-雌烯-3,17-二酮 | CAS号60919-46-2 13beta-乙基-15alp... | CAS号104933-97-3 13-ETHYL-18,19-... | CAS号74177-01-8 3,3-Ethylendith... | CAS号74177-00-7 3,3-Ethylendith...

在 盐酸,三乙胺,间氯过氧苯甲酸体系中,用 四氢呋喃,二氯甲烷,丙酮,Xylene 作为反应溶剂,化学反应 5.75H,反应生成 孕二烯酮
参考文献:A Simple Synthesis Of Gestodene From 18-Methyl-4-Estren-3,17-Dione
标题:A Simple Synthesis Of Gestodene From 18-Methyl-4-Estren-3,17-Dione
摘要:一个简单的合成方法使我们能够从18-甲基-4-雌烯-3,17-二酮在五个步骤和满意的产率中获得孕激素吉司铵.这是通过选择性地将c-3羰基保护为环己酮并在c-16位置引入苯基亚磺酸酯基团实现的.
DOI:10.1055/s-2004-829070

专利信息

专利号:US-7667056-B2
优先权日:2002-08-02
标 题 :Process and new intermediates for the preparation of steroids with a progestogen activity
发明人：GRISENTI PARIDE; PECORA FABIO; VERZA ELISA; LEONI MASSIMO; BOSSI LAURA
权利人:POLI IND CHIMICA SPA
摘要:The present invention relates to a new process of synthesis and to some new intermediates for the preparation of steroids with progestogen activity, more particularly, for the preparation of Desogestrel of formula (I). Said process is characterized by the regioselective reduction of the compound of formula (II) to give the intermediate of formula (III).

专利号:US-6225298-B1
优先权日:1994-11-22
标 题 :Compositions and methods for contraception and for treatment of benign gynecological disorders
发明人：SPICER DARCY V; PIKE MALCOLM CECIL; DANIELS JOHN R
权利人:BALANCE PHARMACEUTICALS INC
摘要:Compositions and methods for use in preventing conception or treating benign gynecological disorders, wherein an effective amount of an antiprogestational agent [e.g., progesterone (progestin, progestogen, gestagen) antagonist or progesterone synthesis inhibitor] administered over a first period of time is combined with an effective amount of a progestogen for a second period of time. The antiprogestational agent is selected from single agents or mixtures thereof. The progestogen is selected from single agents or mixtures of natural or synthetic progestogens. The formulations are effective as contraceptive agents and for treatment of benign gynecological disorders including uterine fibroids, premenstrual syndrome, dysfunctional uterine bleeding, polycystic ovarian syndrome and endometriosis.

专利号:US-2008234340-A1
优先权日:2007-03-09
标 题:Synthesis and characterization of polymorph form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-YL)thiazol-4-YL)benzonitrile
发明人：MIRMEHRABI MAHMOUD; NIU YUPING; TADAYON ABDOLSAMAD; DESHMUKH SUBODH; KU MANNCHING SHERRY
权利人:WYETH CORP
摘要:A polymorph Form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile and methods of preparing Form II are described. Also provided are methods of contraception, treating or preventing fibroids, uterine leiomyomata, endometriosis, dysfunctional bleeding, polycystic ovary syndrome, and hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake, and synchronizing estrus including using polymorph Form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile. n Further provided are methods for preparing polymorph Form I of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile from polymorph Form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile.

专利号:US-2008249148-A1
优先权日:2007-03-09
标题:Synthesis and characterization of polymorph form III 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile
发明人：MIRMEHRABI MAHMOUD; TADAYON ABDOLSAMAD; DESHMUKH SUBODH
权利人:WYETH CORP
摘要:A polymorph Form III of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile and methods of preparing Form III are described. Also provided are methods of contraception, treating or preventing fibroids, uterine leiomyomata, endometriosis, dysfunctional bleeding, polycystic ovary syndrome, and hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake, and synchronizing estrus including using polymorph Form III of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile. n Also provided are methods for preparing polymorph Form I of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile from polymorph Form III of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile.

专利号:EP-1586579-B1
优先权日:2004-03-08
标 题:Process for the preparation of delta(15-16)-17-ketosteroids and use thereof in the synthesis of pharmacologically active compounds
发明人：GRISENTI PARIDE; REZA HELAI SHARZAD; PENGO DANIELE
权利人:EUTICALS SPA

专利号:US-2001016578-A1
优先权日:1997-06-18
标 题 :Compositions and methods for contraception and for treatment of benign gynecological disorders
发明人：SPICER DARCY V; PIKE MALCOLM CECIL; DANIELS JOHN R
权利人:BALANCE PHARMACEUTICALS INC
摘要:Compositions and methods for use in preventing conception or treating benign gynecological disorders, wherein an effective amount of an antiprogestational agent [e.g., progesterone (progestin, progestogen, gestagen) antagonist or progesterone synthesis inhibitor] administered over a first period of time is combined with an effective amount of a progestogen for a second period of time. The antiprogestational agent is selected from single agents or mixtures thereof. The progestogen is selected from single agents or mixtures of natural or synthetic progestogens. The formulations are effective as contraceptive agents and for treatment of benign gynecological disorders including uterine fibroids, premenstrual syndrome, dysfunctional uterine bleeding, polycystic ovarian syndrome and endometriosis.