CAS: 99-92-3; 1-(4-Aminophenyl)Ethanone

上下游产品

CAS号100-19-6 对硝基苯乙酮 | CAS号13329-40-3 4'-碘代苯乙酮 | CAS号99-90-1 4-溴苯乙酮 | CAS号20062-24-2 对叠氮基苯乙酮 | CAS号38063-81-9 4-氨基苯乙酮肟 | CAS号14235-81-5 4-乙炔基苯胺 | CAS号18179-86-7 4',4'''-Azobisa... | CAS号83810-18-8 4-(2-methyl-1,3... | CAS号99-91-2 对氯苯乙酮 | CAS号107045-04-5 N-[(E)-1-(4-ami... | CAS号10517-47-2 Ethanone,1-[4-(... | CAS号109322-08-9 N-[(Z)-1-(4-ami... | CAS号111278-45-6 1-[4-(phenylsul... | CAS号109702-67-2 1-[4-(prop-2-yn... | CAS号3673-53-8 4-(4-氨基-苯基)-噻唑-2-胺 | CAS号5520-66-1 对二乙氨基苯乙酮 | CAS号38283-38-4 N1-(4-乙酰苯基)-2-氯乙胺 | CAS号49647-20-3 异氰酸4-乙酰苯酯 | CAS号54239-37-1 西马特罗

4-碘代苯乙酮置于乙二酸二酰肼,Ammonium Hydroxide,四丁基溴化铵,Potassium Carbonate,2,5-己二酮,Copper(II) Oxide体系中,用 水 作为反应溶剂,化学反应 0.5H,以86%的收率获得产物4-氨基苯乙酮
参考文献:铜/草酰肼/酮通过芳基卤化物与氨水在水中的偶合催化伯芳基胺的合成
标题:铜/草酰肼/酮通过芳基卤化物与氨水在水中的偶合催化伯芳基胺的合成
摘要:铜/草酰肼/酮体系在水中催化芳基卤化物与氨水的偶合反应,从而在没有惰性气氛的情况下产生伯芳基胺.这种方法既快速又简便.偶合反应在90oc下进行20-80分钟,或在室温下进行较长的反应时间.发现多种芳基溴化物和碘化物可用于该三组分催化体系,该体系提供了非常好的分离产率.
DOI:10.1016/j.Tet.2011.05.068

专利信息

专利号:US-2012165520-A1
优先权日:2010-12-23
标题:Process for the synthesis of prodrugs of opioids
发明人：MCGEE PAUL; GARNETT IAN; JUAN E; MANAGE A; CARNIAUX JEAN-FRANCOIS
权利人:MCGEE PAUL; GARNETT IAN; JUAN E; MANAGE A; CARNIAUX JEAN-FRANCOIS
摘要:The present invention provides a process for the synthesis of opioid prodrugs. In particular, the present invention provides a process for the synthesis of opioid prodrugs comprising: treating an opioid, in the form of a salt or a freebase, with a carbonyl synthon to form an activated intermediate and subsequently reacting the activated intermediate with an amine, in the form of a salt or a freebase.

专利号:EP-1383732-B1
优先权日:2001-05-04
标题:Labelling reagents, method for synthesis of said reagents and methods for detecting biological molecules
发明人：BOURGET CECILE; LHOMME JEAN; LAAYOUN ALI; KOTERA MITSUHARU; TREVISIOL EMMANUELLE; MENOU LIONEL; BERNAL MENDEZ ELOY
权利人:BIO MERIEUX; UNIV GRENOBLE 1; CENTRE NAT RECH SCIENT
摘要:The invention concerns a temperature-stable labelling reagent of formula (I), wherein: R<1> represents H or an alkyl, aryl or substituted aryl group; R<2> represents a detectable marker or at least two detectable markers linked together by at least a multimeric structure; L is a linking arm comprising a linear catemer concatenation of at least two covalent bonds; and n is an integer equal to 0 or 1; R<3> and R<4> represent, independently of each other: H, NO2, Cl, Br, F, I, R<2>-(L)n-Y-X-, OR, SR, NR2, R, NHCOR, CONHR, COOR with R = alkyl or aryl, A is a linking arm comprising at least a double bond enabling the conjugation of the diazo function with the aromatic cycle; and u is a whole number between 0 and 2, preferably between 0 and 1; and -Y-X- represents -CONH-, -NHCO-, -CH2O-, -CH2S-. The invention also concerns a method for the synthesis of said markers and uses for labelling biological molecules, in particular nucleic acids, with a labelling reagent bearing the diazomethyl function. The invention is particularly applicable in the field of diagnosis.

专利号:US-5925762-A
优先权日:1996-09-17
标 题:Practical synthesis of urea derivatives
发明人：THAVONEKHAM BOUNKHAM
权利人:BOEHRINGER INGELHEIM CA LTD
摘要:A very mild and efficient approach for the synthesis of ureas is described. Phenyl carbamates were used as intermediates for the preparation of N,N'- substituted ureas. The carbamates were treated with an approximate stoichiometric amount of amine in dimethyl sulfoxide at ambient temperature, generating the ureas in high yield. The reaction was simple, safe, fast, inexpensive, and amenable to large scale production of the product.

专利号:US-5329022-A
优先权日:1991-01-16
标 题:Process for the synthesis of citraconimides
发明人：TALMA AUKE G; HOOFT HENDRIKA P M; VAN DE BOVENKAMP-BOUWMAN ANNA
权利人:AKZO AMERICA INC
摘要:The present invention relates to an improved synthesis method for the making of citraconimides wherein a citraconic anhydride is reacted with 0.5 to 2.0 equivalents of at least one amine salt. This process may be carried out in a solvent and generally leads to excellent yields of the citraconimides with high selectivity and easy purification. The present inventional so relates to a process for the production of citraconic anhydride from itaconic anhydride with an amine or phosphine catalyst and in a cosolvent.

专利号:US-7595156-B2
优先权日:2003-10-23
标 题:Genes for synthesis of FR-008 polyketides
发明人：LEE SANG YUP; DENG ZIXIN; CHEN SHI; JEONG KI JUN; ZHOU XIUFEN
权利人:KOREA ADVANCED INST SCI & TECH
摘要:The present invention relates to the base sequence of whole genes involved in the biosynthesis of FR-008 polyketides derived from Streptomyces sp. FR-008. This base sequence comprises genes coding for ketosynthase (KS), acyl transferase (AT), acyl carrier protein (ACP), ketoreductase (KR), dehydratase (DH) and enoyl reductase (ER) domains, and genes coding for modifier enzymes, such as ABC transporter, cytochrome P450 monooxygenase, ferredoxin, thioesterase, sugar synthetic protein, FAD-dependent monooxygenase, 4-amino-4-deoxychorismate (ADC) synthase and ADC lyase. The gene base sequence according to the present invention can be used to increase the productivity of the existing FR-008 polyketides or produce new FR-008 polyketides, through modification of its parts.

专利号:US-7737287-B2
优先权日:2002-03-28
标 题 :Anomeric derivatives of monosaccharides
发明人：MEUTERMANS WIM; WEST MICHAEL LEO; GIANG THANH LE; ADAMSON GEORGE; SCHAFER KARL; ABBENANTE GIOVANNI
权利人:ALCHEMIA LTD
摘要:This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.