CAS: 1207-69-8; 9-Chloroacridine

相似化合物

6526-92-7 16492-09-4 88914-95-8

上下游产品

9-Chloroacridine N-Oxide 10571-17-2
吖啶 Acridin 260-94-6

2-氯苯甲酸置于铜,Potassium Carbonate,三氯氧磷体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 8.0H,反应生成9-氯吖啶
参考文献:新型合成的基于cr啶的衍生物作为拓扑异构酶i抑制剂
标题:新型合成的基于cr啶的衍生物作为拓扑异构酶i抑制剂
摘要:有效治疗癌症需要抗拓扑异构酶的新型dna结合剂.合成了一系列新的基于a啶的衍生物7A-7D,并评估了它们对k562和hepg-2细胞系的抗增殖活性.在a啶的c9位上被吡啶-2-基-甲氨基取代的化合物7C对两种细胞系均显示出非常好的抗肿瘤活性.通过紫外可见吸收光谱和荧光发射光谱评估了化合物7C的dna结合亲和力.还测试了dna拓扑异构酶i介导的质粒pbr322 Dna的松弛.我们的结果表明,化合物7C 具有非常好抗肿瘤活性和拓扑异构酶i抑制活性的化合物可以开发为进一步化学优化的主要候选对象.
Doi:10.1016/j.Cclet.2014.03.028

专利信息

专利号:WO-2017193288-A1
优先权日:2016-05-10
标题:Synthesis of phosphine ligands bearing tunable linkage: methods of their use in catalysis
发明人：KWONG FUK YEE; CHOY PUI YING; WU YINUO; YANG QINGJING
权利人:THE HONG KONG POLYTECHNIC UNIV SHENZHEN RESEARCH INSTITUTE
摘要:A series of novel linked indolyl phosphine ligands for transition metals, the synthesis thereof and their use in catalytic coupling reactions are provided. The ligands provide improvements of trasition-metal-catalyzed reactions, including the range of substrates scope, reaction conditions and efficieny.

专利号:EP-0383803-B1
优先权日:1987-10-28
标题 :Oligonucleotide-polyamide conjugates
发明人：HARALAMBIDIS JIM; TREGEAR GEOFFREY WILLIAM
权利人:HOWARD FLOREY INST OF
摘要:Oligonucleotide-polyamide conjugates of the formula X-L-Y, where X is a polyamide, Y is an oligonucleotide, and L is a linker which forms a covalent bond with the amino-terminus of the polyamide X and the 3' phosphate group of the oligonucleotide Y. Conjugates may be synthesized by assembling a polyamide on a solid support matrix, adding a suitable linker molecule, followed by synthesis of the oligonucleotide. Methods for detecting specific polynucleotides with oligonucleotide-polyamide conjugates are also described.

专利号:US-5866335-A
优先权日:1994-06-24
标题:Preparation of derivatized 10,10'-substituted-9,9'-biacridine luminescent molecules and signal solutions
发明人：KATSILOMETES GEORGE W; HO PAK T
权利人:KATSILOMETES GEORGE W
摘要:The synthesis of 10,10'-substituted-9,9'-biacridine molecules and their derivatives is disclosed. These molecules are shown to catalyze the production of light by chemiluminescence in the presence of a signal solution having at a pH from about 10.0 to about 14.0, at a concentration effective for producing a chemiluminescent signal, a chelating agent, a sulfoxide, a reducing sugar, an oxidant or combination of oxidants, an alcohol and aqueous sodium tetraborate. These 10,10'-substituted-9,9'-biacridines are used alone or attached to haptens or macromolecules and are utilized as labels in the preparation of chemiluminescent, homogeneous or heterogeneous assays. They are also used in conjunction with other chemiluminescent label molecules to produce multiple analyte chemiluminescent assays.

专利号:US-5525465-A
优先权日:1987-10-28
标 题:Oligonucleotide-polyamide conjugates and methods of production and applications of the same
发明人：HARALAMBIDIS JIM; TREGEAR GEOFFREY W
权利人:FLOREY HOWARD INST
摘要:Oligonucleotide-polyamide conjugates of the formula X--L--Y, where X is a polyamide, Y is an oligonucleotide, and L is a linker which forms a covalent bond with the amino-terminus of the polyamide X and the 3' phosphate group of the oligonucleotide Y. Conjugates may be synthesized by assembling a polyamide on a solid support matrix, adding a suitable linker molecule, followed by synthesis of the oligonucleotide. Methods for detecting specific polynucleotides with oligonucleotide-polyamide conjugates are also described.

专利号:CN-110698399-A
优先权日:2019-10-24
标题 :A kind of palladium-catalyzed synthesis of aryl acridine derivative and preparation method thereof

专利号:US-5552540-A
优先权日:1987-06-24
标题 :Nucleoside derivatives
发明人：HARALAMBIDIS JIM
权利人:FLOREY HOWARD INST
摘要:A nucleoside derivative of formula (1), characterized in that: Y is H or OH or a protected hydroxy group; X is H, a phosphonate group or a phosphoramidite group of formula (II), where R 1 and R 2 are the same or different, and are selected from alkyl and substituted alkyl, which may be branched or unbranched; and Q is a phosphate protecting group; Z is H, a phosphate or triphosphate group or hydroxy protecting group; X' is a C 1-15 alkyl group which may be branched or unbranched; R is an amino protecting group or a fluorophore, or other non-radioactive detectable marker; or the group Y'NHA, where Y' is an alkyl (C 1-40 ) carbonyl group which may be branched or unbranched, and A is an amino protecting group or a fluorophore or other non-radioactive detectable marker. Methods for the synthesis and sequencing of polynucleotides utilizing compounds of formula (I).