CAS: 135062-02-1; (S)-2-Ethoxy-4-(2-((3-Methyl-1-(2-(Piperidin-1-yl)Phenyl)Butyl)Amino)-2-Oxoethyl)Benzoic Acid

上下游产品

CAS号147770-06-7 (S)-瑞格列奈乙基酯 | CAS号110-89-4 六氢吡啶 | CAS号72752-52-4 2-(1-哌啶基)苯腈 | CAS号873-32-5 邻氯苯腈 | CAS号34595-26-1 2-哌啶基-1-苯甲醛

(S)-2-Ethoxy-4-[n-(1-(2-Piperidino-Phenyl)-3-Methyl-1-Butyl)-Aminocarbonylmethyl]-Benzoic Acid-Benzylester置于乙醇,Sodium Hydroxide体系中,化学反应 5.0H,以85.1%的收率获得瑞格列奈
参考文献:一种瑞格列奈的合成方法
标题:一种瑞格列奈的合成方法
摘要:本发明公开了一种瑞格列奈的合成方法,属于医药合成技术领域.该方法包括如下步骤:以邻位卤代苯甲醛为原料,经哌啶取代得2‑哌啶‑1‑苯甲醛化合物1,再与(R)‑叔丁基亚磺酰胺反应得亚胺化合物2,接着与2‑甲基‑1‑丙烯格氏试剂氯化锂反应,经还原得到s‑(+)‑1‑(2‑哌啶苯基)‑3‑甲基正丁胺化合物3;随后与4‑羧基甲基‑2‑乙氧基苯甲酸酯缩合得到s‑(+)‑2‑乙氧基‑4‑[n‑{1‑(2‑哌啶苯基)‑3‑甲基‑1‑丁基}胺基羰基甲基]苯甲酸酯化合物4;最后再经水解得到瑞格列奈5.本发明与其它工艺相比,具有操作简单,原料易得,收率较高,成本低,对环境友好的特点,产物瑞格列奈具有很高的光学纯度,适合工业化生产.

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-8420850-B2
优先权日:2010-05-14
标 题:Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers
发明人：DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE
权利人:DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE; IBERHOSPITEX SA
摘要:The invention comprises compounds which are derived from a drug or a substance with therapeutic properties, and useful as reagents for the synthesis of biostable polymers including said drug in their backbone, namely polyurethanes, polyureas or polyurea urethanes that are biocompatible and biostable. The invention also comprises the processes for preparing the compounds and the polymers, and to the use of these polymers for the manufacture of medical devices.

专利号:US-6686497-B1
优先权日:1999-11-16
标题:Synthesis of 3-ethoxy-4-ethoxycarbonyl phenyl acetic acid, a key acid synthon of repaglinide
发明人：SALMAN MOHAMMAD; BABU J SURESH; RAY PURNA C; BISWAS SUJAY; KUMAR NARESH
权利人:RANBAXY LAB LTD
摘要:The present invention relates to a new and industrially advantageous process for the preparation of 3-ethoxy-4-ethoxy-carbonyl-phenyl acetic acid. This compound is a key intermediate for the synthesis of Repaglinide, an oral hypoglycemic agent.

专利号:WO-2024123268-A1
优先权日:2022-12-09
标 题 :Production of silver nanoparticles by green synthesis using hazelnut husk extract
发明人：AKDOGAN OZAN; GUNDUZ AKDOGAN NILAY; SIVRI DAMLA; KUREL ALI
权利人:BAHCESEHIR UNIV; PIRI REIS UNIV
摘要:The invention relates to synthesis of nanoparticles from hazelnut husk extract by green synthesis with high efficiency. Use of chemical is limited in the present invention and therefore the synthesis of nanoparticles is provided by green chemistry in the present invention. Said hazelnut may be Corylus and said hazelnut husk may be cob or shell of the hazelnut. In an embodiment of the invention said Corylus may be Colyrus colurna, Corylus americana Corylus avellana, Corylus avellana var. Avellana, Corylus avellana var. Pontica, Corylus chinensis, Corylus colchica, Corylus × colurnoides, Corylus cornuta, Corylus cornuta ssp. californica, Corylus cornuta ssp. cornuta, Corylus fargesii, Corylus ferox, Corylus ferox var. ferox, Corylus ferox var. thibetica, Corylus heterophylla, Corylus heterophylla var. heterophylla, Corylus heterophylla var. sutchuensis, Corylus jacquemontii, Corylus maxima, Corylus potaninii, Corylus sieboldiana, Corylus sieboldiana var. mandshurica, Corylus sieboldiana var. sieboldiana, Corylus wangii, Corylus wulingensis or Corylus yunnanensis.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-2009156465-A1
优先权日:2005-12-30
标题:Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
发明人：SATTIGERI JITENDRA A; AHMED SHAHADAT; ANDAPPAN MURUGAIAH M S; SETHI SACHIN; SHARMA LALIMA; PAL CHANCHAL KUMAR; KANDALKAR SACHIN RAMESH; MAHAJAN DIPAK C; KISHORE KAUSHAL; BHATIA SUMATI; GADHAVE ANIL G; BANSAL VINAY S; DAVIS JOSEPH ALEXANAND
权利人:SATTIGERI JITENDRA A; AHMED SHAHADAT; ANDAPPAN MURUGAIAH M S; SETHI SACHIN; SHARMA LALIMA; PAL CHANCHAL KUMAR; KANDALKAR SACHIN RAMESH; MAHAJAN DIPAK C; KISHORE KAUSHAL; BHATIA SUMATI; GADHAVE ANIL G; BANSAL VINAY S; DAVIS JOSEPH ALEXANAND
摘要:The present invention relates to β-amino acid derivatives as dipeptidyl peptidase-IV inhibitors and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating diabetes, especially type 2 diabetes, as well as prediabetes, diabetic dyslipidemia, metabolic acidosis, ketosis, satiety disorders, and obesity. These inhibitors can also be used to treat conditions manifested by a variety of metabolic, neurological, anti-inflammatory, and autoimmune disorders like inflammatory disease, multiple sclerosis, rheumatoid arthritis; viral, cancer and gastrointestinal disorders. The compounds of this invention can also be used for treatment of infertility arising due to polycystic ovary syndrome.