CAS: 136450-11-8; N-(2-Cyano-4-Oxo-4H-Chromen-8-yl)-4-(4-Phenylbutoxy)Benzamide

上下游产品

普仑司特chromenecarboxamide杂质 4-Oxo-8-((4-(4-Phenylbutoxy)Phenyl)Carbonylamino)Chromene-2-Carboxamide 136450-10-7

N-(2-(Hydroxyimino-Methyl)-4-Oxo-4H-Chromen-8-yl)-4-(4-Phenylbutoxy)-Benzamide置于乙酸酐体系中,化学反应 1.0H,以80%的收率获得n-(2-氰基-4-氧代-4H-1-苯并吡喃-8-基)-4-(4-苯基丁氧基)苯甲酰胺
参考文献:A Process For The Preparation Of Nitrile Compounds Used As Intermediates In The Synthesis Of Cysteinyl Leukotrienes Antagonists
标题:A Process For The Preparation Of Nitrile Compounds Used As Intermediates In The Synthesis Of Cysteinyl Leukotrienes Antagonists
摘要:一种制备式(i)化合物或其盐的方法,其中r是氨基,硝基或-Nhcor1基团,其中r1是c1-C6烷基或苯基,可以被-O-(Ch2)N-苯基基团取代,其中n是1至6的整数;包括将式(II)化合物或其盐,作为单个异构体和异构体混合物,其中r如上所定义,与脱水剂反应,必要时在有机溶剂存在下,选配碱性剂;如果需要,将式(i)化合物转化为另一种式(i)化合物或其盐.

专利信息

专利号:EP-1897873-A1
优先权日:2006-08-09
标题:A process for the preparation of nitrile compounds used as intermediates in the synthesis of cysteinyl leukotrienes antagonists