CAS: 159622-10-3; (1R,2S)-1-((Tert-Butoxycarbonyl)Amino)-2-Vinylcyclopropanecarboxylic Acid

相似化合物

259214-55-6 3095621-03-4 213316-49-5

上下游产品

CAS号159622-09-0 (1R,2S)-1-[[(1,... | CAS号259217-95-3 (1R,2S)-REL-1-[... | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号1221174-69-1 sodium (1S,2S)-... | CAS号17447-60-8 2-乙烯基环丙烷-1,1-二羧酸二甲酯 | CAS号1221174-65-7 (1S,2S)-2-vinyl... | CAS号630421-48-6 VANIPREVIR中间体

1-Tert-Butoxycarbonylamino-2-Vinylcyclopropanecarboxylic Acid Ethyl Ester置于sodium Hydroxide,水体系中,用 四氢呋喃 用作溶剂,以61%的收率获得(1R,2S)-1-叔丁氧羰基氨基-2-乙烯基环丙烷甲酸
参考文献:Hepatitis C Virus Inhibitors
标题:Hepatitis C Virus Inhibitors
摘要:本公开涉及三肽化合物,组合物和治疗丙型肝炎病毒(hcv)感染的方法.还公开了含有这些化合物的药物组合物以及在治疗hcv感染中使用这些化合物的方法.

专利信息

专利号:US-2010173939-A1
优先权日:2008-12-22
标题:Antiviral compounds
发明人：LINK JOHN O
权利人:GILEAD SCIENCES INC
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infection. n n n n n n n n n n n n R 1 is:

专利号:US-9328138-B2
优先权日:2011-11-15
标题:HCV NS3 protease inhibitors
发明人：RUDD MICHAEL T; MCCAULEY JOHN; LIVERTON NIGEL; GRISÉ-BARD CHRISTIANE; BROCHU MARIE-CHRISTINE; CHARRON SYLVIE; AULAKH VIRENDER; BACHAND BENOIT; BEAULIEU PATRICK; ZAGHDANE HELMI; HAN YONGXIN; FERRARA MARCO; HARPER STEVEN; SUMMA VINCENZO; CHACKALAMANNIL SAMUEL; VENKATRAMAN SRIKANTH; SHAH UNMESH; VELAZQUEZ FRANCISCO
权利人:MERCK SHARP & DOHME; MSD ITALIA SRL; MERCK CANADA INC
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

专利号:US-2013178413-A1
优先权日:2010-09-21
标题 :Hcv ns3 protease inhibitors
发明人：MCCAULEY JOHN A; LIVERTON NIGEL J; RUDD MICHAEL T; GILBERT KEVIN F; FERRARA MARCO; SUMMA VINCENZO; CRESCENZI BENEDETTA
权利人:MCCAULEY JOHN A; LIVERTON NIGEL J; RUDD MICHAEL T; GILBERT KEVIN F; FERRARA MARCO; SUMMA VINCENZO; CRESCENZI BENEDETTA
摘要:The present invention relates to macrocyclic compounds of formula I that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.