CAS: 17435-72-2; Ethyl 2-(Bromomethyl)Acrylate

该化合物是一种溴化丙烯酯,通常用作有机合成的多用途中间体,其活性溴甲基和丙烯酸酯组体对在聚合反应和交叉组合过程中引入可功能化丙烯酸胶合物很有价值,该化合物在配制改良聚合物,药品和特殊化学品方面特别有用,因为其双重性能可以有效衍生.该化合物在普通有机溶剂中表现出良好的溶解性,便于其在同质反应条件下使用.建议谨慎处理,因为其潜在的色素特性和对湿度的敏感度.该产品通常储存在惰性条件下,以保持稳定性.

结构式图片

相似化合物

72707-66-5 4224-69-5 4513-56-8

欧盟法规

ECHA物质C&L通报

上下游产品

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合成工艺路线路线简述

  • 合成目标产物 Ethyl 2-(Bromomethyl)Acrylate 主要起始原料 Diethyl Malonate
  • (文献来源)合成步骤主要原料 Diethyl Malonate
三溴化磷 以 乙醚,水 用作溶剂,化学反应生成2-溴甲基丙烯酸乙酯
参考文献:Dental Composition
标题:Dental Composition

海关参考信息

专利信息


专利号:WO-2023102600-A1
优先权日:2021-12-06
标题:Synthesis of amphiphilic block copolymers and polymeric nanofibers produced therefrom
发明人:ZETTERLUND PER B; ISHIZUKA FUMI; KIM HYUN JIN; CHATANI SHUNSUKE; NIINO HIROSHI
权利人:NEWSOUTH INNOVATIONS PTY LTD
摘要:The present disclosure relates to the field of synthesis of block copolymers, and polymeric nanofibers having a core-shell morphology produced therefrom. The present disclosure relates to the field of synthesis of block copolymers where one block is more hydrophobic than the other block and is a different composition. The disclosure also relates to uses of these polymeric nanofibers in various applications, such as reinforcing a polymeric matrix and for coatings applications.

专利号:WO-2017051326-A1
优先权日:2015-09-23
标 题 :New processes and intermediates useful in synthesis of nep inhibitors
发明人:MARTIN BENJAMIN; PENN GERHARD; SCHENKEL BERTHOLD; BOURNE SAMUEL; LAU SHING-HING; LEY Steven
权利人:NOVARTIS AG; MARTIN BENJAMIN; PENN GERHARD; SCHENKEL BERTHOLD; BOURNE SAMUEL; LAU SHING-HING; LEY Steven
摘要:The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors such as sacubitril, and prodrugs thereof.

专利号:US-10717718-B2
优先权日:2015-11-17
标 题:5-azido-5-deoxy-2 :3-isopropylidene-D-arabinose compounds; their method of manufacture and their use for the synthesis of ARA-N3, KDO-N3 and 4EKDO-N3
发明人:VAUZEILLES BORIS; MAS PONS JORDI; BARON AURÈLIE
权利人:CENTRE NAT RECH SCIENT
摘要:Disclosed are new compounds of formulae: n nWherein: R 1 and R 2 can be independently H; a C 1 to C 6 alkyl including methyl, ethyl, propyl, butyl; aryl including phenyl, para-methoxyphenyl; or R 1 ,R 2 together with the carbon C-6 can be a cyclopentylidene or cyclohexylidene; each of these groups being substituted or not; and R 3 can be a C 1 to C 6 alkyl including methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl; or aryl including phenyl, methylphenyl, ethylphenyl, each of these groups being substituted or not. The invention also relates to their method of manufacture and their use for the synthesis of Ara-N 3 , Kdo-N 3 and 4eKdo-N 3 .

专利号:US-2006079719-A1
优先权日:2002-04-16
标 题 :Aminated compounds bearing at least an allyl and a difluoromethyl and method used for synthesis thereof
发明人:BONNET-DELPON DANIELE; BEGUE JEAN-PIERRE; LEGROS JULIEN; CROUSSE BENOIT; MEYER FRANCK
权利人:BONNET-DELPON DANIELE; BEGUE JEAN-PIERRE; LEGROS JULIEN; CROUSSE BENOIT; MEYER FRANCK
摘要:The invention relates to aminated compounds bearing at least an allyl and a difluoromethyl and a method used for synthesis thereof. Said compounds comprise at least one carbon bearing: an amine function, an allyl or propargyl radical, a difluoromethylene group, and a hydrogen or a hydrocarbon radical, advantageously selected among those which are electron donors or hardly electroattractive (; 0. 1). The invention is useful for synthesis of fluorinated compounds.

专利号:US-9150498-B2
优先权日:2011-10-25
标题:Process for the preparation of oseltamivir and methyl 3-epi-shikimate
发明人:RAWAT VARUN; DEY SOUMEN; ARUMUGAM SUDALAI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses high yielding enantioselective process for synthesis of Oseltamivir from readily available starting material, cis-1,4-butene diol. The process features incorporation of chirality using sharpless asymmetric epoxidation (AE) and diastereoselective Barbier allylation and construction of cyclohexene carboxylic acid ester core through a ring closing metathesis (RCM) reaction. Further also disclosed herein is synthesis of (−)-methyl 3-epi-shikimate.

专利号:US-2023212107-A1
优先权日:2021-12-30
标 题:Synthesis of para-alkylated syringyl (meth)acrylate derivatives and photopolymerizable compositions for additive manufacturing in dental applications
发明人:CHOUDHARY UMESH UPENDRA; SU JESSICA KALAY
权利人:ALIGN TECHNOLOGY INC
摘要:The present disclosure provides polymerizable monomers which may be used as reactive diluents in additive manufacturing. The polymerizable monomers may have low vapor pressures and may be compatible with a range of low glass transition temperature oligomers.
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主要参考文献

参考标题:Synthesis Of 1‐(3 H )Isobenzofuranone Compounds By Tin Powder Promoted Cascade Condensation Reaction
作者:Shangxian Wang,Ke‐hu Wang,Bo Chang,Danfeng Huang,Yulai Hu |发布日期:2021.7
摘要:An Efficient Approach For The Construction Of Phthalide Compounds Is Developed Through Tin Powder Mediated Cascade Condensation Reaction Of 2-Formylbenzoic Acids With Allyl Bromides Or α-Bromoketone Under Mild Reaction Conditions. This Method Is Easy To Operate And Can Tolerate Various Functional Groups To Give The Corresponding Phthalides In Good To Excellent Yields. The Phthalides Produced From α-Bromoketone

合成参考文献


摘要:Aldabbagh, F.; Gibbons, O., Science of Synthesis, (2010) 45, 725.
摘要:Li, Y.; Xie, W.; Jiang, X., Science of Synthesis Knowledge Updates, (2016) 2, 42.
摘要:Mérour, J.-Y.; Joseph, B., Science of Synthesis Knowledge Updates, (2016) 3, 164.
摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 376.
摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 358.
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