CAS: 29241-60-9; 5-Bromo-2-Chloro-3-Methylpyridine

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CAS号89488-30-2 5-溴-2-羟基-3-甲基吡啶 | CAS号22280-56-4 2-氯-3-甲基-5-硝基吡啶 | CAS号38186-82-2 5-氨基-2-氯-3-甲基吡啶 | CAS号245765-66-6 5-溴-N,3-二甲基-2-吡啶胺 | CAS号887707-21-3 (6-氯-5-甲基吡啶-3-基)甲醇

2-氯-3-甲基-5-硝基吡啶置于铁粉,氯化铵,Copper(I) Bromide,亚硝酸异戊酯体系中,用 乙醇,水,乙腈 用作溶剂,化学反应 3.0H,反应生成2-氯-3-甲基-5-溴吡啶
参考文献: Heteroaromatic Compounds And Uses Thereof[fr] Composés Hétéroaromatiques Et Leurs Utilisations
标题: Heteroaromatic Compounds And Uses Thereof[fr] Composés Hétéroaromatiques Et Leurs Utilisations
摘要:提供杂环芳香化合物及其用途.具体而言,提供公式(i)的杂环芳香化合物,包含其的制药组合物,制备它们的方法以及它们的用途,其中变量如描述中所定义.

专利信息

专利号:US-6017926-A
优先权日:1997-12-17
标题 :Integrin receptor antagonists
发明人：ASKEW BEN C; COLEMAN PAUL J; DUGGAN MARK E; HALCZENKO WASYL; HUTCHINSON JOHN H; MEISSNER ROBERT S; PATANE MICHAEL A; WANG JIABING
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alpha v beta 3, alpha v beta 5 and/or alpha v beta 6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, and tumor growth and metastasis.

专利号:US-6268378-B1
优先权日:1997-12-17
标题 :Integrin receptor antagonists
发明人：DUGGAN MARK E; MEISSNER ROBERT S; PERKINS JAMES J
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the vitronectin receptors alphavbeta3 and/or alphavbeta5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, viral disease, and tumor growth.