4-Methoxy-5-[2-(2-Methoxyphenyl)Ethyl]-1,3-Dioxolan-2-One置于四氯化钛体系中,用 二氯甲烷 作为反应溶剂,化学反应 4.0H,以69%的收率获得产物5-甲氧基-2-萘满酮 参考文献:Ticl4-Promoted Intramolecular Cyclization Of 4-Methoxy-5-Arylethyl-1,3-Dioxolan-2-Ones: An Expedient Method To Prepare 2-Tetralones 标题:Ticl4-Promoted Intramolecular Cyclization Of 4-Methoxy-5-Arylethyl-1,3-Dioxolan-2-Ones: An Expedient Method To Prepare 2-Tetralones 摘要:Dabco Is A Very Effective Calalyst In The Formation Of 4-Methoxy-5-Arylethyl-1,3-Dioxolan-2-Ones 12 From The Corresponding Alpha-Carbonatoaldehyde. Intramolecular,Cyclization Of Cyclic Carbonates 12 Promoted By Ticl4 Affords 2-Tetralones 13 Containing A Variety Of Substituents In High Yields 2009 Elsevier Ltd. All Rights Reserved DOI:10.1016/j.Tetlet.2009.03.185
专利号:US-8729306-B2 优先权日:2010-02-05 标 题:Process for the preparation of nitrogen substituted aminotetralins derivatives 发明人:VASSELIN DAVID; CARLY NICOLAS; ATES CELAL 权利人:VASSELIN DAVID; CARLY NICOLAS; ATES CELAL; UCB PHARMA GMBH 摘要:The present invention provides an alternative synthesis of N-substituted aminotetralines which synthesis comprises catalytic asymmetric hydrogenation of compounds of general formula (A).
专利号:US-8981121-B2 优先权日:2010-06-25 标 题 :Process for the preparation of nitrogen substituted aminotetralins derivatives 发明人:ATES CELAL; SCHULE ARNAUD; PALACIO MAGALI; DEUTSCH PAUL; VASSELIN DAVID; CARLY NICOLAS; PHADTARE GANESH; YERANDE SWAPNIL; DELATINNE JEAN-PIERRE; ESCUDERO HERNANDEZ MARIA LUISA; PINILLA VERONIQUE 权利人:ATES CELAL; SCHULE ARNAUD; PALACIO MAGALI; DEUTSCH PAUL; VASSELIN DAVID; CARLY NICOLAS; PHADTARE GANESH; YERANDE SWAPNIL; DELATINNE JEAN-PIERRE; ESCUDERO HERNANDEZ MARIA LUISA; PINILLA VERONIQUE; UCB PHARMA GMBH 摘要:The present invention provides an alternative synthesis of N-substituted aminotetralines comprising resolution of N-substituted aminotetralins of formula (II), wherein R 1 , R 2 and R 3 are as defined for compound of formula (I).
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