CAS: 33305-77-0; (S)-2-((Tert-Butoxycarbonyl)Amino)-3-(4-Nitrophenyl)Propanoic Acid

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甲基n-{[(2-甲基-2-丙基)氧基]羰基}-4-硝基苯丙氨酸酯置于lithium Hydroxide体系中,用 四氢呋喃,水 作为反应溶剂,化学反应生成 Boc-L-4-硝基苯丙氨酸
参考文献:Design,Synthesis And In Vitro Pharmacology Of Gluk1 And Gluk3 Antagonists. Studies Towards The Design Of Subtype-Selective Antagonists Through 2-Carboxyethyl-Phenylalanines With Substituents Interacting With Non-Conserved Residues In The Gluk Binding Sites
标题:Design,Synthesis And In Vitro Pharmacology Of Gluk1 And Gluk3 Antagonists. Studies Towards The Design Of Subtype-Selective Antagonists Through 2-Carboxyethyl-Phenylalanines With Substituents Interacting With Non-Conserved Residues In The Gluk Binding Sites
摘要:In Order To Identify Compounds Selective For The Gluk1 And Gluk3 Subtypes Of Kainate Receptors We Have Designed And Synthesized A Series Of (S)-2-Amino-3-((2-Carboxyethyl)Phenyl)Propanoic Acid Analogs With Hydrogen Bond Donating And Accepting Substituents On The Aromatic Ring. Based On Crystal Structures Of Gluk1 In Complex With Related Ligands,The Compounds Were Designed To Explore Possible Interactions With Non-Conserved Residues Outside The Glutamate Ligand Binding Site And Challenge The Water Binding Network. Apart From Obtaining Gluk1 Selective Antagonists One Analog With A Phenyl-Substituted Urea (Compound 31) Showed Some Preference For Gluk3 Over Gluk1-Receptors. Docking Studies Indicate That This Preference May Be Attributed To Contacts Between The Nh Of The Urea Substituent And Non-Conserved Ser741 And Ser761 Residues.
DOI:10.1016/j.Bmc.2014.07.045

专利信息

专利号:US-7928236-B2
优先权日:2005-06-10
标题 :Fluorescent amino acid derivatives
发明人：TAKI MASUMI; SISIDO MASAHIKO
权利人:UNIV OKAYAMA NAT UNIV CORP
摘要:The subject of the present invention is to provide a fluorescent substance excitable under visible light, having higher photostability and a long fluorescence lifetime. Another subject is to provide a fluorescent substance consists of a non-natural amino acid applicable to peptide synthesis systems. n Searching fluorescent substances, which are fluorescent amino acids and excitable under visible light, having the lowest possible molecular weight for a high photostability resulted in forming a condensed polycyclic aromatic compound by subjecting a compound having an acridone structure to substitution with an amino acid and further condensation with a benzene ring. Thus, the subject is achieved by the fluorescent substance consisting of amino acid-substituted benzoacridone derivative excitable under visible light.