CAS: 41963-20-6; 4-Bromo-3-Methylbenzonitrile

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CAS号170229-98-8 4-溴-3-甲基苯甲酰胺 | CAS号6933-10-4 4-溴-3-甲基苯胺 | CAS号537-92-8 N-乙酰基-3-甲苯胺 | CAS号7697-28-1 4-溴-3-甲基苯甲酸 | CAS号143-33-9 氰化钠 | CAS号544-92-3 氰化亚铜 | CAS号313546-18-8 2-甲基-4-氰基苯硼酸 | CAS号42872-85-5 4-碘-3-甲基苯甲腈 | CAS号148672-39-3 3-(4-溴-3-甲基苯基)-... | CAS号1975-53-7 4-氰基-2-甲基苯甲酸 | CAS号190197-86-5 3-(溴甲基)-4-溴苯腈 | CAS号160313-49-5 4-Bromo-3-(dibr... | CAS号89003-95-2 2-溴-5-氰基苯甲醛 | CAS号78775-11-8 4-溴-3-甲基苯甲醛 | CAS号78881-21-7 4-氨基-3-甲基苯腈 | CAS号128196-01-0 艾司西酞普兰

3-甲基-4-溴苯甲酸置于ammonium Hydroxide,三聚氯氰,三乙胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 0.2H,反应生成 4-溴-3-甲基苯甲腈
参考文献:新型苯并氧杂硼烷作为一类新型抗疟药的合成及其构效关系
标题:新型苯并氧杂硼烷作为一类新型抗疟药的合成及其构效关系
摘要:设计并合成了一系列含硼的苯并氧杂硼酸化合物,用于围绕7-(hoocch 2 Ch 2)-1,3-二氢-1-羟基-2,1-苯并氧杂硼酸的结构-活性关系研究(1),目的是发现一种新的抗疟疾治疗方法.化合物1表现出 对恶性疟原虫的最佳效价(ic 50 = 26 Nm),并且具有非常好的类药物特性,具有低分子量(206.00),低clogp(0.86)和高水溶性(ph 7时为750μg/ Ml) .
DOI:10.1016/j.Bmcl.2010.12.034

专利信息

专利号:US-12435086-B2
优先权日:2020-04-29
标题:Synthesis of heterocyclic compounds
发明人：LIN JACK; WALTERS JASON
权利人:PLEXXIKON INC
摘要:Provided herein are intermediates and processes useful for facile synthesis of compounds of Formula 2:wherein R1 is C(O)R2; R2 is alkyl optionally substituted with 1-5 halogens; G is phenyl or a 5-6 membered heteroaryl optionally substituted with 1-2 R3; and each R3 is independently C1-C6 alkyl, CN, C1-C6 alkyl-CN, 3-6 membered cycloalkyl, or 4-6 membered heterocycloalkyl.

专利号:US-2024217965-A1
优先权日:2020-04-29
标 题 :Synthesis of heterocyclic compounds

专利号:EP-3103803-B1
优先权日:2008-10-27
标 题 :Intermediates for the synthesis of mtor kinase inhibitors

专利号:US-11299484-B2
优先权日:2018-10-10
标 题 :Inhibiting fatty acid synthase (FASN)
发明人：MARTIN MATTHEW W; ZABLOCKI MARY-MARGARET; MENTE SCOT; DINSMORE CHRISTOPHER; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:FORMA THERAPEUTICS INC
摘要:The present disclosure is directed to inhibitors of FASN. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of FASN. For instance, the disclosure is concerned with compounds and compositions for inhibition of FASN, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of FASN, and methods of synthesis of these compounds.

专利号:EP-3660020-A1
优先权日:2008-10-27
标题 :Process for the synthesis of mtor kinase inhibitors

专利号:BR-112016017679-B1
优先权日:2014-02-21
标题 :5-BENZYLISOQUINOLINE DERIVATIVE COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES, PROCESS FOR THE SYNTHESIS OF SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM