CAS: 94-74-6; (4-Chloro-2-Methylphenoxy)Acetic Acid

该化合物是一种属于苯氧乙酸类别的有机化合物,其特点是芳香环上存在氯基和甲基组,影响其化学特性和生物活动,该化合物一般是白色的,白色的,脱白晶体状固体,在水中溶解性有限时可溶于有机溶剂,主要用作除草剂,对各种广叶类杂草有效,并且通过干扰植物生长过程发挥作用.该化合物的动作方式包括模仿天然植物激素,导致无节制的生长和最终植物死亡.安全考虑包括对水生生物的潜在毒性,以及需要谨慎处理以尽量减少环境影响.与许多化学物质一样,适当的储存和处置方法对于减轻其使用的风险至关重要.

结构式图片

欧盟法规

统一分类与标签ECHA物质工作场所安全标识要求ECHA物质C&L通报REACH预注册废弃物危险特性清单

上下游产品

CAS号1878-49-5 2-甲苯氧基乙酸 | CAS号104-94-9 对甲氧基苯胺 | CAS号625-36-5 3-氯丙酰氯 | CAS号1570-64-5 4-氯-2-甲基苯酚 | CAS号79-11-8 氯乙酸 | CAS号2698-38-6 2-(4-氯-2-甲基苯氧基)乙酸乙酯 | CAS号7399-57-7 2-(4-chloro-2-m... | CAS号52106-86-2 Sodium 4-chloro... | CAS号105-36-2 溴乙酸乙酯 | CAS号7553-56-2 碘 | CAS号95-71-6 鹿蹄草素 | CAS号553-97-9 甲基苯醌 | CAS号95-48-7 邻甲酚 | CAS号488-17-5 3-甲基邻苯二酚 | CAS号2698-38-6 2-(4-氯-2-甲基苯氧基)乙酸乙酯 | CAS号1878-49-5 2-甲苯氧基乙酸 | CAS号1570-65-6 4,6-二氯-2-甲基苯酚 | CAS号1570-64-5 4-氯-2-甲基苯酚 | CAS号57117-31-4 2,3,4,7,8-五氯二苯并呋喃

合成工艺路线路线简述

    2-甲基苯氧基乙酸置于氯体系中,用 水 作为反应溶剂,化学反应生成 2-甲基-4-氯苯氧乙酸
    参考文献:Preparation Of Chlorinated Phenoxyalkanoic Acids
    标题:Preparation Of Chlorinated Phenoxyalkanoic Acids
    摘要:一种制备2,4-二氯苯氧乙酸或2-甲基-4-氯苯氧乙酸或α-2,4-二氯苯氧丙酸或α-2-甲基-4-氯苯氧丙酸的方法,通过在水中反应苯氧乙酸或2-甲基苯氧乙酸或α-苯氧丙酸或α-2-甲基苯氧丙酸与氯,其中从水溶液中沉淀出苯氧乙酸或苯氧丙酸,将氯气以不超过悬浮液中消耗速率的速度通入苯氧乙酸或2-甲基苯氧乙酸或α-苯氧丙酸或α-2-甲基苯氧丙酸的悬浮液中,在30oc至70oc下反应,直到悬浮液中吸收了理论上需要的氯气量的100%至110%,然后从悬浮液中分离出2,4-二氯苯氧乙酸或2-甲基-4-氯苯氧乙酸或α-2,4-二氯苯氧丙酸或α-2-甲基-4-氯苯氧丙酸.

    海关参考信息

    专利信息


    专利号:WO-2024256370-A1
    优先权日:2023-06-13
    标 题 :Synthesis of glufosinate using an amidase-based process
    发明人:ZIMMERMANN GUNTHER; POTT MORITZ STEFAN
    权利人:BASF SE
    摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.

    专利号:US-2025120400-A1
    优先权日:2021-12-10
    标题:Synthesis of glufosinate using a hydantoinase-based process
    发明人:DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN
    权利人:BASF SE
    摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.

    专利号:US-11919928-B2
    优先权日:2016-03-16
    标题 :Method for producing dihydrotentoxin
    发明人:KUBO TAKASHI; MACHIDA MASAYUKI; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI
    权利人:KUMIAI CHEMICAL INDUSTRY CO
    摘要:An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.

    专利号:EP-0609638-A1
    优先权日:1992-10-27
    标 题:Water soluble polymeric systems of phytohormones with slow release: synthesis and application
    发明人:TSATSAKIS ARISTIDIS; VLACHAKIS ELEUTERIOS IOANIS; SHTILMAN ISAAK MICHAIL; SHASHKOVA MICHAIL IRINA; ALLAKHVERDIEV SURKHAI RAGIM IN
    权利人:TSATSAKIS ARISTIDIS; VLACHAKIS ELEUTERIOS IOANIS; SHTILMAN ISAAK MICHAIL; SHASHKOVA MICHAIL IRINA; ALLAKHVERDIEV SURKHAI RAGIM IN
    摘要:Our discovery concerns the method of synthesis and the application of new chemical products for plant growing. These new products are polymeric derivatives of low molecular weight plant growth regulators and are characterized by slow release of the auxin from the polymeric carrier. By copolymerisation of allylic esters of the low molecular weight auxins with the acrylic (or the methylacrylic) acid and the following modification of the synthesized co-polymers of acids to their corresponding ammonium salts, water soluble polymeric auxins possesing optimal molecular weight and desirable (high) content of the low molecular weight auxin in the polymer were prepared. The method of synthesis and the final products fulfill the requirements of the preparation technology and of their application respectively. We suggest the application of the new products in agronomy (i.e. treatment of seeds, rootstocks, plants, scions, cutting etc) either by themselves or by combination of them with other chemicals. The chemical structure of the new products we discover is :n n    R = H-, -CH3, Au = auxin residue

    专利号:US-2021386068-A1
    优先权日:2018-11-07
    标题 :Compositions comprising pyridine carboxylate herbicides and very long chain fatty acid (vlcfa) synthesis inhibitor herbicides
    发明人:KISTER JEREMY; SATCHIVI NORBERT M
    权利人:CORTEVA AGRISCIENCE LLC
    摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a VLCFA synthesis inhibitor herbicide. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof, and (b) a VLCFA synthesis inhibitor herbicide.

    专利号:US-2021352899-A1
    优先权日:2018-11-07
    标题 :Compositions comprising pyridine carboxylate herbicides and fatty acid and lipid synthesis inhibitor herbicides
    发明人:KISTER JEREMY; SATCHIVI NORBERT M
    权利人:CORTEVA AGRISCIENCE LLC
    摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof.
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    主要参考文献


    1: Tennakoon DA, Perera KA, Hathurusinghe LS. An unusual case of non-fatal poisoning due to herbicide 4-chloro-2-methyl phenoxyacetic acid (MCPA). Forensic Sci Int. 2014 Oct;243:90-4. doi: 10.1016/j.forsciint.2014.04.039. Epub 2014 May 6. doi: 10.1016/j.scitotenv.2014.06.129. Epub 2014 Jul 19. doi: 10.1021/jf404095h. Epub 2013 Dec 16. doi: 10.1016/j.scitotenv.2013.11.009. Epub 2013 Nov 28. doi: 10.1016/j.ecoenv.2014.08.012. Epub 2014 Aug 28. doi: 10.1007/s11356-015-4633-1. Epub 2015 May 7. doi: 10.1002/ps.3929. Epub 2014 Nov 21. doi: 10.1016/j.toxlet.2014.01.018. Epub 2014 Jan 27. doi: 10.1007/s11356-014-3693-y. Epub 2014 Oct 15. doi: 10.1007/s10532-013-9660-3. Epub 2013 Aug 28. doi: 10.1007/s11356-015-4622-4. Epub 2015 May 7. doi: 10.1016/j.jconhyd.2013.07.003. Epub 2013 Jul 16. doi: 10.1080/03601234.2015.1018754. doi: 10.1080/03601234.2015.1120618. Epub 2016 Jan 19. doi: 10.1016/j.talanta.2012.05.053. Epub 2012 May 30. doi: 10.1007/s11033-011-1030-9. Epub 2011 Jun 14. pii: e01529-14. doi: 10.1128/genomeA.01529-14.
    18: Kimura O, Tsukagoshi K, Hayasaka M, Endo T. Transepithelial transport of 4-chloro-2-methylphenoxyacetic acid (MCPA) across human intestinal Caco-2 cell monolayers. Basic Clin Pharmacol Toxicol. 2012 Jun;110(6):530-6. doi: 10.1111/j.1742-7843.2011.00850.x. Epub 2012 Jan 16. doi: 10.1007/s10661-011-2317-y. Epub 2011 Sep 14. doi: 10.2134/jeq2015.07.0358.

    合成参考文献


    摘要:Jurewicz J, Hanke W, Sobala W, Ligocka D, Gawora-Ziółek M. [Occupational exposure to pesticides among farmers of the Łódź' voivodeship agricultural area]. Med Pr. 2011;62(1):9–16.
    参考文献:10.1007/s00204-011-0734-x
    摘要:Kimura O, Tsukagoshi K, Hayasaka M, Endo T. Uptake of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) and dicamba (3,6-dichloro-2-methoxybenzoic acid) from the apical membranes of the human intestinal Caco-2 cells. Arch Toxicol. 2012 Jan;86(1):55–61. doi: 10.1007/s00204-011-0734-x.
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