CAS: 97519-39-6; Ceftibuten

上下游产品

头孢克洛 Cefaclor 53994-73-3
Bis(Diphenylmethyl) 7(R)-Glutaroylaminoceph-3-Em-4-Carboxylate
Bis(Diphenylmethyl) 7(R)-Glutaroylamino-3-Hydroxyceph-3-Em-4-Carboxylate
Bis(Diphenylmethyl) 3-Chloro-7(R)-Glutaroylaminoceph-3-Em-4-Carboxylate
7-Amino-3-No-Cephalosporin-4-Carboxylic Acid Benzhydryl 36923-21-4
Diphenylmethyl 7-Amino-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate 36923-21-4
Benzhydryl (6R,7R)-7-[(5-Benzhydryloxy-5-Oxopentanoyl)Amino]-3-Methylsulfonyloxy-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Octane-2-Carboxylate
Benzhydryl (6R,7R)-7-[(5-Benzhydryloxy-5-Oxopentanoyl)Amino]-3-Hydroxy-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Octane-2-Carboxylate

Diphenylmethyl (6R,7R)-7-[(E,Z)-2-(2-Benzyloxycarbonylamino-4-Thiazolyl)-4-(3-Methyl-2-Butenyloxycarbonyl)-2-Butenoylamino]-8-Oxo-5-Thia-1-Azabicyclo[4,2,0]oct-2-Ene-2-Carboxylate置于aluminum (Iii) Chloride,苯甲醚,盐酸体系中,用 水 作为反应溶剂,化学反应 0.5H,反应生成 头孢布坦
参考文献:Ceftibuten:开发基于头孢菌素 C 的商业工艺.第三部分.将 3-Exomethylene-7(R)-Glutaroylaminocepham-4-Carboxy 酸 1(S)-Oxide 转化为 Ceftibuten 的方法
标题:Ceftibuten:开发基于头孢菌素 C 的商业工艺.第三部分.将 3-Exomethylene-7(R)-Glutaroylaminocepham-4-Carboxy 酸 1(S)-Oxide 转化为 Ceftibuten 的方法
摘要:上述论文(bernasconi,E.;lee,J.;roletto,J.;sogli,L.;walker,D. Org. Process Res. Dev. 2002,6,152 和 Bernasconi,E.;genders,D. ; Lee,J.; Longoni,D.; Martin,Cr; Menon,V.; Roletto,J.; Sogli,L.; Walker,D.; Zappi,G.; Zelenay,P.; Zhang,H. Org . Process Res. Dev. 2002,6,158) 描述了一种用于制备 3-Exomethylene-7(R)-Glutaroylaminocepham-4-Carboxy Acid 1(S)-Oxide (3) 的高产全水性方法通过酶转化和电化学还原从发酵的头孢菌素 C 肉汤中提取,无需
DOI:10.1021/op010071Y

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2024197774-A1
优先权日:2021-04-16
标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
发明人：LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
权利人:UNIV TEXAS
摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

专利号:US-5847116-A
优先权日:1994-12-09
标 题 :Process for the preparation of intermediates useful in the synthesis of cephalosporins
发明人：WALKER DEREK; LEE JUNNING; MARTIN CHARLES R; ZHANG HAIYAN; SOGLI LORIS; BERNASCONI ERMANNO; MENON VINOD PARAKKAL
权利人:SCHERING CORP; ANTIBIOTICOS SA
摘要:A process is described for preparing 3-exomethylene cephalosporanic acid derivatives for use in the synthesis of cephalosporin antibiotics such as ceftibuten. The process comprises electrochemical reduction of a compound of the formula (IV) ##STR1## wherein: R 3 is ##STR2## is an optional sulfoxide group; n is 2 or 3; R 1 is H and R is H or NHR 2 , where R 2 is H or a protecting group selected from C 6 H 5 CH 2 OC(O)--, C 6 H 5 C(O)-- or C 1 -C 6 alkoxy-C(O)--; or wherein R and R 1 together with the carbon atom to which they are attached comprise --C(O)--, and produces the desired 3-exomethylene compounds with low levels of the corresponding 3-methyl tautomers.

专利号:US-8557979-B2
优先权日:2004-06-10
标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
发明人：CHOI WOO-BAEG; KOWALIK EWA
权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-10933051-B2
优先权日:2017-06-09
标 题 :Carbapenem compounds and compositions for the treatment of bacterial infections
发明人：CHOI WOO-BAEG; TOMIOKA TAKASHI; JOO HYUNG-YEUL; TRUONG PHONG; MIN BRIAN
权利人:FOB SYNTHESIS INC
摘要:The present invention provides carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections, including drug resistant or multiple-drug resistant bacterial infections, and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.