专利号:US-2023119068-A1 优先权日:2020-02-13 标题:Methods for rapid synthesis of pyranoanthocyanins 发明人:ZHU XIAOYI; STRAATHOF NICOLE; MIYAGUSUKU-CRUZADO GONZALO; GIUSTI M MONICA; CANO ISRAEL GARCIA; JIMENEZ-FLORES RAFAEL 权利人:OHIO STATE INNOVATION FOUNDATION 摘要:The present disclosure provides methods for the rapid synthesis of pyranoanthocyanins.
专利号:US-10005720-B2 优先权日:2013-04-05 标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same 发明人:SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L 权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL 摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.
专利号:US-7767826-B2 优先权日:2007-10-05 标题 :Process for the synthesis of L-(+)-ergothioneine 发明人:TRAMPOTA MIROSLAV 权利人:PHARMATECH INTERNATIONAL INC 摘要:This invention relates to a novel process for the preparation of optically pure L-(+)-ergothioneine. The process for the chemical synthesis of L-ergothioneine comprises steps which consist of reacting L-histidine alkyl ester with an acid halide, chloroformate or pyrocarbonate in the presence of a base, hydrolysis of the alkyl-(S,Z)-2,4,5-triamidopent-4-enoate to obtain a (S)-alkyl 2,5-diamido-4-oxopentanoate, acid catalyzed hydrolysis of the (S)-alkyl 2,5-diamido-4-oxopentanoate followed by reaction with a metal thiocyanate to obtain the thiohistidine, protection of the sulfur of thiohistidine as the tert-butyl thioether, dialkylation of the primary amine to obtain a tertiary amine, quaternization of the tertiary amine, and removal of the protecting group to obtain the desired (S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trialkylammonio)propanoate (I). This process affords a better yield and is capable of practical application at large scale.
专利号:US-11059835-B2 优先权日:2014-08-15 标 题 :Synthesis of cephalosporin compounds 发明人:WALLER DAVID; GAZDA GREGORY; MINDEN ZACHARY; BARTON LISA; LEIGH CLIFTON 权利人:MERCK SHARP & DOHME 摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction.
专利号:US-5300703-A 优先权日:1993-04-05 标 题:Alkylphenol synthesis using heteropoly acid catalysts 发明人:KNIFTON JOHN F 权利人:TEXACO CHEMICAL 摘要:Disclosed is a one step method for synthesis of alkylphenols which comprises reacting phenol with the corresponding olefin under adiabatic conditions in the presence of a catalyst comprising a heteropoly acid represented by the structure: H8-n(XM12O40) where x=P or Si, M=Mo or wv and n is an integer which is 4 or 5, alone, or deposited on an inert support, at a temperature of from 60 degrees C. to 250 degrees C. and a pressure of from near atmospheric to about 500 psi.
专利号:US-5171896-A 优先权日:1992-03-05 标 题 :Alkylphenol synthesis using acid-modified inorganic clay catalysts 发明人:KNIFTON JOHN F; SHEU YU-HWA E 权利人:TEXACO CHEMICAL 摘要:Disclosed is a one step method for synthesis of alkylphenols which comprises reacting phenol with the corresponding olefin under adiabatic conditions in the presence of a catalyst comprising an acidic montmorillonite clay having the structure: Mx/nn+xyH2O(Al4-xMgx)(Si8)O20(OH)4 where M represent the interlamellar (balancing cation, normally sodium or lithium) and x, y and n are integers, wherein the acidic clay has been pretreated with an acid and optionally has deposited thereon an acid selected from the group consisting hydrogen fluoride, a fluorosulfonic acid or a mineral acid, at a temperature of from 60 DEG C. to 250 DEG C. and a pressure of from near atmospheric to about 500 psi.