CAS: 102961-72-8; Mirtazapine

专利信息

专利号:US-7632918-B2
优先权日:2005-02-28
标题 :Semi-synthetic glycopeptides with antibiotic activity
发明人：CHU DANIEL; PREOBRAZHENSKAYA MARIA N; PRINTSEVSKAYA SVETLANA S; OLSUFYEVA EUGENIA N
权利人:NOVARTIS VACCINES & DIAGNOSTIC
摘要:Semi-synthetic glycopeptides having antibacterial activity are based on modifications of the eremomycin, A82846B, vancomycin, teicoplanin, and A-40,926 scaffolds, in particular, acylation of the sugar moieties on these scaffolds with certain acyl groups; and/or conversion of an acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides; or having a combination of an alkylation modification of the amino substituent on the amino-substituted sugar moiety on these scaffolds with certain alkyl groups or acylation modification of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain alkyl groups, and conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for the synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

专利号:RU-2125058-C1
优先权日:1991-07-29
标 题 :Derivative of antibiotic 'a 40926', methods of its synthesis, pharmaceutical composition