CAS: 122536-94-1; (S)-3-Hydroxypyrrolidine Hydrochloride

相似化合物

100243-39-8 86070-82-8 100858-32-0

上下游产品

CAS号127913-44-4 (S)-4-氯-3-羟基丁腈 | CAS号104641-59-0 (S)-(+)-1-甲基-3-羟基吡咯烷 | CAS号100858-32-0 (S)-(+)-1-Cbz-3-吡咯烷醇 | CAS号100858-33-1 (|R|)-(-)-1-Cbz...

(3S)-N-苄基-3-羟基吡咯烷-2,5-二酮置于palladium 10% On Activated Carbon,氢气,盐酸体系中,用 乙醇,异丙醇 用作溶剂,20.0~75.0 °C,550.01 Kpa 条件下,反应 5.0H,以88%的收率获得(S)-3-羟基吡咯烷盐酸盐
参考文献:一种(S)-3-吡咯烷醇盐酸盐的合成方法
标题:一种(S)-3-吡咯烷醇盐酸盐的合成方法
摘要:本发明公开了一种(S)‑3‑吡咯烷醇盐酸盐的合成方法,属于药物合成领域,该方法以l‑苹果酸与苄胺为原料经过脱水酰胺化得到(3S)‑n‑苄基‑3‑羟基吡咯烷‑2,5‑二酮,之后一锅法还原,脱苄基,成盐合成(S)‑3‑吡咯烷醇盐酸盐.本发明合成路线短,操作简单,收率高,产品纯度好,利于工业化生产.

专利信息

专利号:US-7153960-B2
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
发明人：ZHOU JIACHENG; OH LYNETTE M; MA PHILIP; LI HUI-YIN; CONFALONE PASQUALE
权利人:BRISTOL MYERS SQUIBB CO
摘要:A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. n nThese compounds are useful as factor Xa inhibitors.

专利号:WO-2025087822-A1
优先权日:2023-10-23
标 题 :New process for the preparation of (3r)-fluoropyrrolidine hydrochloride
发明人：ENGL PASCAL STEPHAN; HILDBRAND STEFAN; MOESSNER CHRISTIAN; STOECKLI MARKUS; STUTZ ALFRED
权利人:HOFFMANN LA ROCHE; HOFFMANN LA ROCHE
摘要:The present invention relates to a new process for the preparation of (3R)-3-fluoropyrrolidine hydrochloride or an acceptable salts thereof via a N-Boc-(3S)-3-hydroxypyrrolidine intermediate. The process is suitable for the synthesis of N-Boc-(3S)-3- hydroxypyrrolidine at technical scale in high, not less than 99.85%-a/a optical purity and a purity of not less than 99.8%-a/a. The high quality N-Boc-(3S)-3-hydroxypyrrolidine can be converted to (3R)-3-fluoropyrrolidine hydrochloride exhibiting an optical purity of not less than 99.95%-a/a and a purity of not less than 99.5%-a/a thus making it a suitable intermediate for manufacturing of pharmaceutical active compounds.

专利号:US-9937151-B2
优先权日:2010-06-18
标题 :Carbapenem antibacterials with gram-negative activity
发明人：CHOI WOO-BAEG; GRUSZECKA-KOWALIK EWA; JOO HYUNG-YEUL; LIU SHUANGPEI; MAO SHULI; LI YONGFENG; KIM DEOG-IL
权利人:FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

专利号:US-2003181466-A1
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones

专利号:US-2005245566-A1
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones

专利号:CN-1639147-A
优先权日:2001-12-10
标题 :Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyridin-2-ones