CAS: 124937-51-5; (R)-2-(3-(Diisopropylamino)-1-Phenylpropyl)-4-Methylphenol

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CAS号828933-86-4 (R)-6-methyl-4-... | CAS号108-18-9 二异丙胺 | CAS号848768-06-9 托特罗定 | CAS号40546-94-9 6-甲基-4-苯基色满-2-酮 | CAS号124935-88-2 2-甲氧基-5-甲基-N,N-... | CAS号106-44-5 对甲酚 | CAS号827007-19-2 (4R)-6-甲基-4-苯基色满-2-酮 | CAS号207679-81-0 (R)-5-羟甲基托特罗定 | CAS号286930-02-7 弗斯特罗定

(R)-托特罗定l-酒石酸盐置于碳酸氢钠体系中,用 乙酸乙酯 用作溶剂,以6.9 G的收率获得托特罗定
参考文献: Novel (R) And Rac 3-(2-(Allyloxy)-5-Methylphenyl)-N,N-Diisopropyl-3-Phenylpropan-1-Amine And Its Use For Synthesis Of (R) And Rac-2-(3-(Diisopropylamino)-1-Phenylpropyl)-4-(Hydroxymethyl)Phenol[fr] Nouveau (R) Et 3-(2-(Allyloxy)-5-Méthylphényl)-N,N-Diisopropyl-3-Phénylpropan-1-Amine Racémique Et Son Utilisation Pour La Synthèse De (R) Et De 2-(3-(Diisopropylamino)-1-Phénylpropyl)-4-(Hydroxyméthyl)Phénol Racémique
标题: Novel (R) And Rac 3-(2-(Allyloxy)-5-Methylphenyl)-N,N-Diisopropyl-3-Phenylpropan-1-Amine And Its Use For Synthesis Of (R) And Rac-2-(3-(Diisopropylamino)-1-Phenylpropyl)-4-(Hydroxymethyl)Phenol[fr] Nouveau (R) Et 3-(2-(Allyloxy)-5-Méthylphényl)-N,N-Diisopropyl-3-Phénylpropan-1-Amine Racémique Et Son Utilisation Pour La Synthèse De (R) Et De 2-(3-(Diisopropylamino)-1-Phénylpropyl)-4-(Hydroxyméthyl)Phénol Racémique
摘要:本发明涉及新颖的手性3-(2-(烯丙氧基)-5-甲基苯基)-N,N-二异丙基-3-苯丙胺(5)和消旋3-(2-(烯丙氧基)-5-甲基苯基)-N,N-二异丙基-3-苯丙胺()以及其在改进和工业上有利的制备手性和消旋形式2-(3-(二异丙胺基)-1-苯基丙基)-4-(羟甲基)苯酚的过程中的使用.此外,本发明还涉及其制备.

专利信息

专利号:WO-2017137955-A1
优先权日:2016-02-14
标题:Novel (r) and rac 3-(2-(allyloxy)-5-methylphenyl)-n,n-diisopropyl-3- phenylpropan-1-amine and its use for synthesis of (r) and rac-2-(3- (diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol
发明人：THOMBARE PRAVIN SAHADEV
权利人:CELESTIS PHARMACEUTICALS PVT LTD
摘要:The present invention relates to novel chiral 3-(2-(allyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine (5) and racemic 3-(2-(allyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine () and its use in improved and industrially advantageous process for preparation of chiral and racemic form of 2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol. Further, present invention relates to preparation of the same.

专利号:US-2008280855-A1
优先权日:2005-06-22
标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles
发明人：CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH
摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

专利号:EP-1862449-A1
优先权日:2006-05-31
标 题 :A shortened synthesis of substituted hydroxymethyl phenols
发明人：BROWNE ROISIN; KIKELLY MICHAEL
权利人:SCHWARZ PHARMA LTD
摘要:The present disclosure relates to a process for the preparation of 2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)phenol or its phenolic monoesters or salts thereof, characterized by the steps of na) reacting a compound of formula (II)n nwith a mixture of MeMgCl and Mg in a solvent, nb) optionally reducing the temperature of the Grignard reagent to a lower temperature than in step a), and n nreacting the resulting Grignard reagent with an excess of a carbonate in a solvent, to obtain a compound of formula (III)n nwherein A is a C 1 -C 6 alkyl group, and then further reacting the compound of formula (III) in a known manner to obtain the desired end product.

专利号:US-8299306-B2
优先权日:2006-06-08
标 题 :Accelerated synthesis of substituted hydroxymethyl phenols
发明人：ENNIS SETH C; KENNEDY BRYAN D
权利人:ENNIS SETH C; KENNEDY BRYAN D
摘要:This disclosure relates to process for the preparation of a compound of formula (I) wherein R is hydrogen, a straight or branched C 1 -C 6 alkyl-carbonyl group or a phenylcarbonyl group, or a salt thereof, comprising the following steps: a) adding to a suspension of Mg a compound of formula (II) R 1 (MgX) n —LiY wherein n is 1 or 2; R 1 is an aromatic, aliphatic, carbocyclic or heterocyclic organic group having 1 to 24 carbon atoms; X and Y are independently selected from Cl, Br and I, b) reacting said reaction mixture with a suitable halogenated compound in a solvent to form a Grignard reagent, c) reacting said Grignard reagent with a suitable linear, branched or cyclic carbonate to obtain a compound of formula (IV) wherein A is a linear, branched or cyclic C 1 -C 6 alkyl group, and preferably a methyl group, and then further reacting the compound of formula (IV) in a known manner to obtain a compound of formula (I) and optionally salt formation.

专利号:US-8703996-B2
优先权日:2010-03-09
标题:Short synthesis of tolterodin, intermediates and metabolites
发明人：STERK DAMJAN
权利人:STERK DAMJAN; LEK PHARMACEUTICALS
摘要:A process is described for the preparation of intermediates which can be used for preparation of agents for urinary incontinence therapy, specifically to 2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol and its prodrugs.

专利号:US-10035796-B2
优先权日:2014-08-14
标题:Crystalline forms of a BACE inhibitor, compositions, and their use
发明人：KAZAKEVICH IRINA; TRZASKA SCOTT; FENG TAO
权利人:MERCK SHARP & DOHME
摘要:The present invention provides a novel synthesis of verubecestat, and two novel crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an Aβ pathology and/or a symptom or symptoms thereof. Non-limiting examples of such Aβ pathologies, including Alzheimer's disease, are disclosed herein.