CAS: 13473-26-2; Spiro[isobenzofuran-1(3H),9'-[9H]Xanthen]-3-One, 2',4',5',7'-Tetrabromo-4,5,6,7-Tetrachloro-3',6'-Dihydroxy-

Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于乙醇体系中,化学反应生成2,3,4,5-四氯-6-(2,4,5,7-四溴-6-羟基-3-氧代-3H-占吨-9-基)苯甲酸
参考文献:Schultz,Tab. No. 596
标题:Schultz,Tab. No. 596

专利信息

专利号:WO-2012016973-A1
优先权日:2010-08-02
标 题:Invention related to contact allergens
发明人：SCHMIDT MARC; GOEBELER MATTHIAS; BADRINARAYANAN RAGHAVAN
权利人:TRANSMIT GMBH; SCHMIDT MARC; GOEBELER MATTHIAS; BADRINARAYANAN RAGHAVAN
摘要:The problem of the underlying invention is to foresee a new method and a new class of substances to treat and or reduce hypersensivity (CHS) with mammals, especially humans to nickel, especially Ni 2+ . Surprisingly it was found, that the site-specific h TLR4 inhibition as potential strategy for therapeutic intervention without affecting vital immune responses. Here we demonstrate that Ni 2+ induces an inflammatory response via direct activation of human Toll-like receptor 4 (hTLR4). Remarkably, Ni 2+ induces TLR4 activation is species-specific since mouse TLR4 (mTLR4) is incapable to generate this response. Studies with mutant TLR4 proteins revealed a requirement of the non-conserved histidines 456 and 458 of h TLR4 for activation by Ni 2+ but not by the natural ligand LPS. Accordingly, transgenic h TLR4 expression in Tlr4 -deficient mice allowed efficient sensitization to Ni 2+ and elicitation of CHS. Allergies to nickel (Ni 2+) are the most frequent cause of contact hypersensitivity (CHS) in industrialized countries. Both a T lymphocyte-specific signal and a proinflammatory signal are required for efficient CHS development. Here we demonstrate that Ni 2+ induces an inflammatory response via direct activation of human Toll-like receptor 4 (hTLR4). Remarkably, Ni 2+ induced TLR4 activation is species-specific since mouse TLR4 (m TLR4) is incapable to generate this response. Studies with mutant TLR4 proteins revealed a requirement of the non-conserved histidines 456 and 458 of h TLR4 for activation by Ni2+ but not by the natural ligand LPS. Accordingly, transgenic h TLR4 expression in Tlr4 -deficient mice allowed efficient sensitization to Ni 2+ and elicitation of CHS. Our data implicate site-specific h TLR4 inhibition as potential strategy for therapeutic intervention without affecting vital immune responses. Furthermore it is shown that hypersensitivity-related inflammatory response via direct activation of human Toll-like receptor 4 (h TLR4) is not only induced by nickel but also by cobalt (Co 2+ ). Moreover, the invention surprisingly describes synthesis of truncated h TLR4 molecules (s-h TLR4) missing the transmembrane domain and the C-terminal part of the protein that are applicable in a method for identification of substances to treat and or reduce hypersensitivity (CHS) or sepsis with mammals by inhibition of h TLR4 activation.

专利号:US-12076423-B2
优先权日:2015-12-23
标题 :Spiculisporic acid-based composition
发明人：AGNAOU REDA; MARION CATHERINE
权利人:OREAL
摘要:Composition in the form of an oil-in-water emulsion that includes at least 1% of an oil phase, and an aqueous phase. The composition includes 0.1 to 15 wt % spiculisporic acid relative to the total weight of the composition, at least one base selected from amino acids and alkanolamines in an amount suitable for forming at least a monosalt of spiculisporic acid, less than 3% glycol(s) and/or polyol(s) relative to the total weight of the composition, at least one UV filter and/or an additive selected from volatile aromatic materials such as essential oils and fragrance substances, fillers, dyeing materials such as pigments, mother-of-pearl or particles with a metallic sheen, moisturizers, anti-wrinkle or anti-age agents, peeling agents, antioxidants, active ingredients stimulating the synthesis of epidermal and/or dermal macromolecules, dermo-relaxing agents, depigmentation agents, deodorant agents and mixtures thereof.

专利号:EP-4206236-A1
优先权日:2021-12-28
标题 :Compounds, their synthesis and compositions comprising the compounds for enhanced deposition of polymers onto hair surfaces
发明人：BREAKSPEAR STEVEN; NÖCKER BERND; WEITZEL JOHANNA; PAEZ JULIETA; PEARSON SAMUEL; BRÃœCK STEFAN; CAMPO ARANZAZU DEL
权利人:KAO CORP
摘要:The present invention is on polymers derivatized with an organic deposition-enhancing group for their enhanced deposition onto keratin fibers, especially human hair. The deposition-enhancing group is a di-hydroxyl phenolic compound with a spacer alkyl group bound to a reactive amine or carboxyl group, which reacts with one of the hydroxyl, carboxyl, primary and secondary amine groups on the polymeric backbone. The invention is on the method of synthesizing such compounds and compositions comprising the compounds.

专利号:US-2003186237-A1
优先权日:2001-02-14
标题:Methods and compositions of amplifying RNA
发明人：GINSBERG STEPHEN D; CHE SHAOLI
权利人:BAYLOR COLLEGE MEDICINE
摘要:The present invention pertains to a method that will increase the efficiency of second strand cDNA synthesis through a mechanism of “terminal continuationâ€? before further RNA amplification by RNA transcription using, for example, a bacteriophage promoter. In a specific embodiment, a transcription promoter is attached to the 5′ region of cDNA through the same mechanism of “terminal continuationâ€?. Genetic signals are subsequently amplified in a linear manner through RNA transcription. In specific embodiments, the orientation of the transcribed RNA is either sense or antisense, depending on the desired downstream application. In other embodiments, the present invention pertains to methods for extraction and amplification of RNA, particularly mRNA, from histologically stained tissues and cells.

专利号:US-5096710-A
优先权日:1989-05-27
标 题 :Poison bait for control of noxious insects
发明人：MINAGAWA FUMIYASU; KOHAMA TAKUJI; KAWADA HITOSHI; SHINJO GORO; MAEDA KAZUYUKI
权利人:SUMITOMO CHEMICAL CO
摘要:A bait composition in a tablet form, which comprises as the essential components (a) at least one insect-growth controlling agent chosen from (a-1) insect juvenile hormone-like compounds and (a-2) insect chitin-synthesis inhibitors, (b) dextrin and (c) a plant oil in an amount of not more than 10% by weight to the total bait composition.

专利号:US-5300293-A
优先权日:1989-05-27
标题:Poison bait for control of noxious insects
发明人：MINAGAWA FUMIYASU; KOHAMA TAKUJI; KAWADA HITOSHI; OHTSUBO TOSHIRO; SHINJO GORO; MAEDA KAZUYUKI
权利人:SUMITOMO CHEMICAL CO
摘要:A bait composition in a tablet form, which comprises as the essential components (a) at least one insect-growth controlling agent selected from (a-1) insect juvenile hormone-like compounds and (a-2) insect chitin-synthesis inhibitors in a microencapsulated form and (b) dextrin, optionally with an additional or auxiliary agent(s).