CAS: 138530-94-6; (R)-2-(((3-Methyl-4-(2,2,2-Trifluoroethoxy)Pyridin-2-yl)Methyl)Sulfinyl)-1H-Benzo[d]Imidazole

上下游产品

CAS号1240684-26-7 N-camphorsulfon... | CAS号103577-40-8 兰索拉唑硫醚 | CAS号103577-45-3 兰索拉唑 | CAS号152402-98-7 2-[[(3-甲基-4-硝基-...

2-[[[3-甲基-4-(2,2,2三氟乙氧基)-2-吡啶]-甲基]硫基]-1H-苯并咪唑置于l-(+)-酒石酸二乙酯,Titanium(Iv) Isopropylate体系中,用 二氯甲烷,水 用作溶剂,以73.6 %的收率获得(R)-兰索拉唑
参考文献:利用原位红外精确控制高纯度右兰索拉唑合成过程中的氧化反应
标题:利用原位红外精确控制高纯度右兰索拉唑合成过程中的氧化反应
摘要:右兰索拉唑是第二代质子泵抑制剂,用于治疗胃食管反流病和糜烂性食管炎.它通常是通过卡根反应通过不对称硫氧化来合成的.但由于硫氧化程度难以控制,制备过程中不同批次杂质含量变化,导致所得右兰索拉唑质量较低,难以满足药典要求.控制硫的氧化程度,准确判断反应终点,原位采用红外光谱法监测右兰索拉唑合成过程中的反应状态.该方法已在公斤级生产中得到成功验证,最终产品收率为72.9%~73.6%,纯度为99.86%~99.89%.
Doi:10.1021/acs.Oprd.3C00098

专利信息

专利号:US-8962851-B2
优先权日:2011-12-27
标题:One-pot process for the preparation of benzimidazole derivatives
发明人：DWIVEDI SHRIPRAKASH DHAR; PRASAD ASHOK; PAL DAYA RAM
权利人:CADILA HEALTHCARE LTD
摘要:The present invention discloses one pot process for enantioselective synthesis of single enantiomers of substituted sulphoxides 2-(2-pyridinylmethylsulphinyl)-1H-benzimidazoles or said compounds in an enantiomerically enriched form.

专利号:US-9428486-B1
优先权日:2014-07-29
标 题 :Efficient process for the preparation of Esomeprazole (S)-Binol complex
发明人：STABILE PAOLO; BERTOLAZZI MORENO; FACCIN NICOLA; RASIA DIEGO
权利人:F I S - FABBRICA ITALIANA SINTETICI S P A; F I S —FABBRICA ITALIANA SINTETICI S P A
摘要:Object of the present invention is an improved process for the preparation of Esomeprazole (S)-BINOL complex which is a key intermediate for the synthesis of Esomeprazole and salts thereof.

专利号:US-9631181-B2
优先权日:2009-12-08
标 题 :Synthesis of prazole compounds
发明人：BONG YONG KOY; CLAY MICHAEL D; COLLIER STEVEN J; MIJTS BENJAMIN; VOGEL MICHAEL; ZHANG XIYUN; ZHU JUN; NAZOR JOVANA; SMITH DEREK J; SONG SHIWEI
权利人:CODEXIS INC
摘要:The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

专利号:WO-2012163563-A1
优先权日:2011-05-31
标题:New strontium salts, synthesis and use thereof in the treatment of osteoporosis
发明人：MOURELLE MANCINI MARISABEL; DEL CASTILLO NIETO JUAN CARLOS
权利人:LACER SA; MOURELLE MANCINI MARISABEL; DEL CASTILLO NIETO JUAN CARLOS
摘要:The present invention relates to a strontium salt (I) wherein n is an integer which can take the values of 0 or 1 m is an integer which can take the values of 0 or 1 R is hydrogen or methyl and stereoisomers or hydrates thereof, to methods for its synthesis, and use in the treatment and/or prophylaxis of a cartilage and/or bone disease and/or conditions resulting in a dysregulation of cartilage and/or bone metabolism in a mammal.

专利号:WO-2011071982-A2
优先权日:2009-12-08
标题 :Synthesis of prazole compounds

专利号:US-2016076008-A1
优先权日:2009-12-08
标题:Synthesis of prazole compounds