专利号:US-2023373003-A1 优先权日:2022-05-17 标 题 :Seedless Synthesis of Anisotropic Gold Nanoflowers with Cellular Control and Drug Delivery Applications 发明人:OH EUNKEU; SUSUMU KIMIHIRO; SANGTANI AJMEETA; ROGERS Katherine; NAG OKHIL K; LEE KWAHUN; VURGAFTMAN IGOR; WEIBLEN R JOSEPH; KIM MIJIN; DELEHANTY JAMES B 权利人:US GOV SEC NAVY 摘要:A new seedless synthesis of anisotropic nanoscale gold nanoflower (AuNF) particles uses bidentate thiolate ligands to protect the nanoparticle surface and a combination of reagents (for example, ligand, ascorbic acid, and hydroxide) to synthesis AuNF with controlled size and anisotropic properties. Compared to prior art gold nanospheres, AuNF produced approximately a 15-fold improvement in a drug delivery assay.
专利号:US-9732112-B2 优先权日:2010-05-28 标 题:Synthesis of 2′,3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization 发明人:MA ZHAOCHUN; MULLAH KHAIRUZZAMAN BASHAR; EASON ROBERT G 权利人:LIFE TECHNOLOGIES CORP 摘要:Methods for preparation of 2′,3′-dideoxynucleotides support structures, such as 2′,3′-dideoxyguanosine, 2′,3′-dideoxyadenosine, and 3′-deoxythymidine support structures are disclosed. Various methods of using such structures are also provided, such as their use for automated DNA synthesis and pyrophosphorolysis activated polymerization.
专利号:US-7223845-B2 优先权日:1998-06-16 标 题:Synthetic glycosulfopeptides and methods of synthesis thereof 发明人:CUMMINGS RICHARD D; MCEVER RODGER P 权利人:UNIV OKLAHOMA 摘要:A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewis x group or a sialyl Lewis a group. In a preferred version the GSPs have an O-glycan comprising a β1,6 linkage to a GalNAc. The present invention further contemplates in vitro methods of the synthesis of these GSPs without the use of the cells and methods of their use in vivo as powerful anti-inflammatory antithrombotic, or anti-metastatic compounds. The invention also contemplates a method of synthesizing oligosaccharides by cleaving the glycan from the GSP.
专利号:WO-2025007089-A1 优先权日:2023-06-30 标 题:Compositions, methods and kits for nucleic acids synthesis and amplification 发明人:BERKMAN JENNIFER; URBONAS IGNAS; ABREU DANIELA CRUZ; LIU CHENGJING; YEN CHIA AN; ONG KIMBERLIE SOOHOO; WEI WEI; GOMEZ SILVAN MARIA CINTA 权利人:LIFE TECHNOLOGIES CORP; THERMO FISHER SCIENTIFIC BALTICS UAB 摘要:The present disclosure is directed to compositions, methods and kits useful for the synthesis of nucleic acid molecules. More specifically, compositions, methods and kits are provided for the amplification of nucleic acid molecules in an one-step qPCR or RT-qPCR procedure comprising a reverse transcriptase, a DNA polymerase, at least one dNTP, and at least one stabilizing agent, wherein said at least one stabilizing agent increases stability of an assembled polymerase chain reaction.
专利号:US-7718578-B2 优先权日:2003-03-31 标 题 :Method of synthesis and testing of combinatorial libraries using microcapsules 发明人:GRIFFITHS ANDREW DAVID; ABELL CHRIS; HOLLFELDER FLORIAN; MASTROBATTISTA ENRICO 权利人:MEDICAL RES COUNCIL 摘要:The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets. The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalized into the microcapsules.
专利号:US-12006540-B2 优先权日:2015-09-28 标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis 发明人:JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J 权利人:UNIV COLUMBIA 摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.