CAS: 19493-44-8; 1-Chloroisoquinoline

相似化合物

7742-73-6 630421-73-7 19493-45-9

上下游产品

CAS号1532-72-5 异喹啉-N-氧化物 | CAS号119-65-3 异喹啉 | CAS号1532-84-9 1-氨基异喹啉 | CAS号491-30-5 异喹诺酮 | CAS号120569-13-3 benzophenone O-... | CAS号4594-71-2 2-甲基异喹啉-1(2H)-酮 | CAS号63870-82-6 2-Ethyl-1,2-dih... | CAS号491-30-5 异喹诺酮 | CAS号374554-54-8 5-氨基-1-氯异喹啉 | CAS号1721-93-3 1-甲基异喹啉 | CAS号17999-93-8 1,1'-联异喹啉 | CAS号23165-19-7 调节安 | CAS号226-65-3 Isoquinolino[1'... | CAS号27302-13-2 1-Isoquinolinea... | CAS号205264-33-1 4-(异喹啉-1-基)哌嗪-1... | CAS号86520-96-9 1-乙炔-异喹啉 | CAS号119-65-3 异喹啉

异喹啉置于间氯过氧苯甲酸,三氯氧磷体系中,用 二氯甲烷 用作溶剂,化学反应 10.25H,反应生成1-氯异喹啉
参考文献:利用氯仿-Coware 化学钯催化的异喹啉氨基羰基化
标题:利用氯仿-Coware 化学钯催化的异喹啉氨基羰基化
摘要:羰基构成了几种药物分子和材料的组成部分;因此,羰基化化合物的合成对于合成化学家和药物化学家来说仍然是一个有趣的研究领域.处理有毒 Co 气体有几个局限性;因此,使用安全有效的技术进行原位或非原位从无毒且廉价的前体中产生一氧化碳是非常可取的.在已探索用于产生 Co 气体的几种前体中,氯仿由于其成本效益高且易于获得,可证明是一种有前途的 Co 替代品.然而,基于氯仿的一锅式羰基化反应需要强碱性条件才能水解氯仿,这可能会影响底物的官能团耐受性和放大反应.这些限制可以通过可用于非原位的两室反应器 (Coware) 来克服在一个室中通过氯仿水解产生 Co,并在温和条件下在另一个室中促进安全的羰基化反应.通过钯催化的医学相关杂环核心(即异喹啉和喹啉)的氨基羰基化,探索了这种"氯仿-Coware"技术的多功能性.
Doi:10.1021/acs.Joc.2C01629

专利信息

专利号:WO-2021257669-A1
优先权日:2020-06-17
标题 :Synthesis of substituted arylmethylureas, analogues, and crystalline forms thereof and methods of using same
发明人：PALLERLA MAHESH KUMAR; PAMULAPATI GANAPATI REDDY; SPINK JAN MICHELLE
权利人:ARBUTUS BIOPHARMA CORP; ARBUTUS BIOPHARMA INC
摘要:The present disclosure includes synthetic methods for preparing certain substituted (hetero)arylmethyl urea compounds, compositions comprising the same, and crystalline forms thereof, which can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) infections in a patient.

专利号:US-6936600-B2
优先权日:1999-04-01
标题:Sorbitol dehrydrogenase inhibitors
发明人：CHU-MOYER MARGARET Y; MYLARI BANAVARA L; ZEMBROWSKI WILLIAM J
权利人:PFIZER
摘要:This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, n n nwherein R 1 , R 2 and R 3 are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, diabetic macroangiopathy and diabetic cardiomyopathy by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an aldose reductase inhibitor and to methods of treating or preventing diabetic complications therewith. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and to methods of treating cardiomyopathy and other heart-related problems therewith. This invention is also directed to certain intermediates used in the synthesis of the compounds of formula I and to processes for preparing those intermediates.

专利号:US-8883763-B2
优先权日:2010-03-01
标题 :Use of isoquinolones for preparing drugs, novel isoquinolones and method for synthesising same
发明人：POPOV ANDREI; JUHEM AURÉLIE; FLORENT JEAN-CLAUDE; N GUYEN CHI-HUNG
权利人:POPOV ANDREI; JUHEM AURÉLIE; FLORENT JEAN-CLAUDE; N GUYEN CHI-HUNG; UNIV JOSEPH FOURIER; CENTRE NAT RECH SCIENT; INST CURIE
摘要:The use of isoquinolones for preparing drugs, including novel isoquinolones as well as their synthesis method. In particular, isoquinolone derivatives used in the treatment of pathological angiogenesis, and more particularly of cancer.

专利号:US-6835835-B1
优先权日:2003-12-05
标题:Synthesis for organometallic cyclometallated transition metal complexes
发明人：HUO SHOUQUAN
权利人:EASTMAN KODAK CO
摘要:The invention provides a process for forming an organometallic cyclometallated complex comprising the step of reacting, in an aprotic organic solvent, an organozinc complex of a desired organic ligand with a metal complex of an element of atomic number 74 to 79 bearing a leaving group.

专利号:US-2008139558-A1
优先权日:2006-02-24
标题 :Quinolones useful as inducible nitric oxide synthase inhibitors
发明人：SMITH NICHOLAS D; ROPPE JEFFREY R; BONNEFOUS CELINE; PAYNE JOSEPH E; ZHUANG HUI; CHEN XIAOHONG; LINDSTROM ANDREW K; DURON SERGIO G; HASSIG CHRISTIAN A; NOBLE STEWART A
权利人:KALYPSYS INC
摘要:The present invention relates to novel quinolones of Formula I that inhibit inducible NOS synthase together with methods of synthesizing and using the compounds including methods for inhibiting or modulating nitric oxide synthesis and/or lowering nitric oxide levels in a patient by administering the compounds for the treatment of disease.

专利号:US-8278322-B2
优先权日:2005-08-01
标题 :HCV NS3 protease inhibitors
发明人：HOLLOWAY M KATHARINE; LIVERTON NIGEL J; MCCAULEY JOHN A; RUDD MICHAEL T; VACCA JOSEPH P; LUDMERER STEVEN W; OLSEN DAVID B
权利人:HOLLOWAY M KATHARINE; LIVERTON NIGEL J; MCCAULEY JOHN A; RUDD MICHAEL T; VACCA JOSEPH P; LUDMERER STEVEN W; OLSEN DAVID B; MERCK SHARP & DOHME
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.