CAS: 260415-63-2; 6-(2,6-Dichlorophenyl)-8-Methyl-2-((3-(Methylthio)Phenyl)Amino)Pyrido[2,3-D]Pyrimidin-7(8H)-One

上下游产品

3-methylmercaptoaniline 6-(2,6-dichlorophenyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester (4-methylamino-2-methylsulfanyl-pyrimidin-5-yl)-methanol

4-甲胺基-2-甲硫基-5-嘧啶甲酸乙酯置于盐酸,Manganese(Iv) Oxide,Lithium Aluminium Tetrahydride,水,Potassium Carbonate,间氯过氧苯甲酸体系中,用 四氢呋喃,氯仿,N,N-二甲基甲酰胺 用作溶剂,化学反应生成6-(2,6-二氯苯基)-8-甲基-2-[[3-(甲硫基)苯基]氨基]吡啶并[2,3-D]嘧啶-7(8H)-酮
参考文献:第3部分:保留缺口的γ-分泌酶抑制剂:2-取代的氨基吡啶并嘧啶酮的sar研究.
标题:第3部分:保留缺口的γ-分泌酶抑制剂:2-取代的氨基吡啶并嘧啶酮的sar研究.
摘要:为了寻找作为γ-分泌酶抑制剂的新型先导化合物,合成了氨基吡啶并[2,3-D]嘧啶-7-(i)的类似物,并评估了其对淀粉样β肽产生和notch1受体裂解的抑制作用.由γ-分泌酶介导.选定的嘧啶嘧啶,例如1,8,9,10,11和16是对notch1受体加工没有影响的γ-分泌酶抑制剂.
Doi:10.1016/j.Bmcl.2016.03.077

专利信息

专利号:US-11285169-B2
优先权日:2013-03-13
标题 :Methods for modulating chemotherapeutic cytotoxicity
发明人：ROBERTS DAVID D; SOTO PANTOJA DAVID R
权利人:US HEALTH
摘要:Methods of reducing cytotoxicity of a chemotherapeutic agent to non-cancer cells by administering to a subject with cancer an effective amount of an agent that inhibits CD47 signaling and a DNA damaging agent, such as an anthracycline, topoisomerase inhibitor, or nucleotide synthesis inhibitor, are provided. Example disclosed methods reduce cardiotoxicity. In one example, the methods include administering to a subject with cancer an effective amount of a CD47 antisense morpholino oligonucleotide and an anthracycline such as doxorubicin. Methods of increasing cytotoxicity of a chemotherapeutic agent in cancer cells by administering to a subject with a tumor an effective amount of an agent that inhibits CD47 signaling and a DNA damaging agent such as an anthracycline, topoisomerase inhibitor, or nucleotide synthesis inhibitor, are also provided. In some embodiments, the inhibitor of CD47 signaling is administered to the subject before, during, or after the administration of the DNA damaging agent.