CAS: 32451-88-0; (1S,3R,4S,5R)-4-[4-(3,4-Dihydroxyphenyl)-2-Oxobut-3-Enyl]-3-[3-(3,4-Dihydroxyphenyl)Prop-2-Enoyloxy]-5-Hydroxy-1-Methylcyclohexane-1-Carboxylic Acid

该化合物是一种属于咖啡因基酸和咖啡叶酸酯酯的多酚化合物,其特征是,该化合物有两种碳因子,附于五角酸脊的4和5个位置,通常存在于各种植物中,特别是咖啡和某些水果中,有助于其抗氧化特性;该化合物显示出重要的生物活动,包括防炎,抗氧化剂和潜在的...

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合成工艺路线路线简述

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    专利信息


    专利号:WO-0063152-A1
    优先权日:1999-02-22
    标题:Acetylated and related analogues of chicoric acid as hiv integrase inhibitors
    发明人:BURKE TERRENCE R; ZHAIWEI LIN; ZHAO HE; NEAMATI NOURI; POMMIER YVES
    权利人:US HEALTH; BURKE TERRENCE R; ZHAIWEI LIN; ZHAO HE; NEAMATI NOURI; POMMIER YVES
    摘要:Chicoric acid analogues and derivatives have activity against HIV-1 integrase. The structural features that are required for this activity are elucidated by assaying these analogues and derivatives against HIV-1 integrase. Furthermore, methods of synthesis of the enantiomers of chicoric acid itself, as well as its analogues and derivatives, are disclosed. Additionally, methods of use of chicoric acid analogues and derivatives to inhibit HIV-1 integrase are disclosed, as are compositions comprising chicoric acid analogues and derivatives.

    专利号:CN-102796746-A
    优先权日:2012-08-07
    标题:A gene segment regulating the synthesis of Solanaceae flavonoids and caffeoylquinic acid and its application

    专利号:CN-102796746-B
    优先权日:2012-08-07
    标题 :Gene segment for regulating synthesis of solanaceae flavonoids and caffeoyl quinic acid, and uses thereof

    专利号:CN-114395566-B
    优先权日:2022-03-28
    标题:Application of sweet potato ERF transcription factor IbERF4 in promoting synthesis of plant chlorogenic acid substances

    专利号:JP-2009207492-A
    优先权日:2008-02-06
    标 题 :Enzymatic synthesis of cinnamic acid derivatives

    专利号:CN-114395566-A
    优先权日:2022-03-28
    标题:Application of sweet potato ERF transcription factor IbERF4 in promoting the synthesis of chlorogenic acids in plants
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    合成参考文献


    参考文献:10.1016/s0026-895x(25)09385-x
    摘要:Robinson WE, Cordeiro M, Abdel-Malek S, Jia Q, Chow SA, Reinecke MG, Mitchell WM. Dicaffeoylquinic acid inhibitors of human immunodeficiency virus integrase: inhibition of the core catalytic domain of human immunodeficiency virus integrase. Molecular Pharmacology. 1996 Oct;50(4):846–55. doi: 10.1016/s0026-895x(25)09385-x.
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