CAS: 3731-52-0; Pyridin-3-Ylmethanamine

相似化合物

102297-41-6 63361-56-8 98-92-0

上下游产品

CAS号100-54-9 3-氰基吡啶 | CAS号100-55-0 3-吡啶甲醇 | CAS号51892-16-1 (E)-Pyridine-3-... | CAS号59-67-6 烟酸 | CAS号500-22-1 吡啶-3-甲醛 | CAS号123-91-1 1,4-二氧六环 | CAS号64-17-5 乙醇 | CAS号108-99-6 3-甲基吡啶 | CAS号53558-25-1 灭鼠优 | CAS号500-22-1 吡啶-3-甲醛 | CAS号5746-86-1 (±)-降烟碱 | CAS号142744-23-8 1-N-[2-[[5-[(di... | CAS号1198018-55-1 2,4-bis(2-pyrid... | CAS号1198018-58-4 N-(3-(3-pyridyl... | CAS号3682-35-7 2,4,6-三(2-吡啶基)均三嗪 | CAS号41661-57-8 1-((吡啶-3-基)甲基)-4-哌啶酮 | CAS号201215-93-2 1-PHENYL-3-(PYR... | CAS号22977-34-0 3-(乙酰氨基甲基)嘧啶

在 水,Sodium Hydroxide体系中,用 四氢呋喃,甲醇 用作溶剂,化学反应生成3-氨甲基吡啶
参考文献:含锰配合物的苯并咪唑片段催化酮和腈的氢化硅烷化
标题:含锰配合物的苯并咪唑片段催化酮和腈的氢化硅烷化
摘要:报道了一种新的双齿(nn)-Mn(i)配合物的合成,并研究了其对酮和腈还原的催化活性.在比较苯并咪唑配体负载的其他各种mn(i)配合物的反应性时,观测到带有6-甲基吡啶和苯并咪唑片段的mn(i)配合物对酮的单氢化硅烷化和腈的二氢化硅烷化表现出最高的催化活性.使用该方案,将广泛的酮选择性地还原为相应的甲硅烷基醚.在不饱和酮的情况下,观测到羰基在烯烃键上的化学选择性还原.另外,使用该配合物还实现了几个腈的选择性二氢硅烷化.用自由基清除剂进行的机械研究表明,在催化反应过程中自由基种类的参与.Mn(i)配合物与苯基硅烷的化学计量反应揭示了新的mn(i)配合物的形成.
Doi:10.1016/j.Tet.2020.131439

专利信息

专利号:WO-2021260722-A1
优先权日:2020-06-21
标 题:Design, synthesis of novel oxyindole inhibitors of denv rna dependent rna polymerase
发明人：GUNDLA RAMBABU; ASTHANA SHAILENDRA; BHATTACHARYYA SANKAR; MADDIPATI VENKATANARAYANA CHOWDARY; MITTAL LOVIKA; KAUR JASKARAN; RAWAT YOGITA
权利人:TRANSLATIONAL HEALTH SCIENCE AND TECH INSTITUTE; GANDHI INSTITUTE OF TECH AND MANAGEMENT
摘要:The present invention is drawn to novel compounds of formula I, II and III, including any conformational isomeric form, salts and solvates for inhibition of DENV RNA dependent and RNA polymerase. The present invention also discloses a process of synthesis of the compounds, compositions comprising the said compounds and use of the compounds and treatment comprising the compounds of the present invention.

专利号:US-9688644-B2
优先权日:2009-04-30
标 题 :Synthesis of Tetracyclines and intermediates thereto
发明人：MYERS ANDREW G; KUMMER DAVID A; LI DERUN; HECKER EVAN; DION AMELIE; WRIGHT PETER M
权利人:HARVARD COLLEGE
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-8722852-B2
优先权日:2006-04-28
标 题 :Cosmetic composition for stimulating the synthesis of proteins of the basement membrane
发明人：ZIEGLER HUGO; IMFELD DOMINIK; STOCKLI MARTIN; HEIDL MARC
权利人:ZIEGLER HUGO; IMFELD DOMINIK; STOCKLI MARTIN; HEIDL MARC; DSM IP ASSETS BV
摘要:Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R 1 is H, C 1 -C 20 -alkyl, cycloalkyl or aryl-C 1 -C 4 -alkyl, n is 1-4, X is —O—, —NH— or —NR 2 — and R 2 H or C 1 -C 20 -alkyl; and at least one compound corresponding to the above formula (I) but in which XR 1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is —NR 2 — and both R 1 and R 2 are different from H, and the compounds corresponding to formula (I) but in which XR 1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid, as such.

专利号:US-8076479-B2
优先权日:2006-08-28
标题 :Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives and intermediates
发明人：CHEN FRANK XING; KEERTIKAR KARTIK M; KUO SHEN-CHUN; LEE HONG-CHANG; RAGHAVAN RAMANI R; WU GEORGE G; XIE JI
权利人:CHEN FRANK XING; KEERTIKAR KARTIK M; KUO SHEN-CHUN; LEE HONG-CHANG; RAGHAVAN RAMANI R; WU GEORGE G; XIE JI; SCHERING CORP
摘要:Disclosed is a process for the synthesis of compounds of Formula I n nby sequentially aminating, first with a primary amine and then with a secondary amine, an intermediate compound of the structure of Formula E1,n n nwherein R 1 is a linear, branched, or cyclic alkyloxy functional group of the structure (—R 2a —OH), R 2a is a linear, branched or cyclic alkyl group, R 2 is a linear, branched or cyclic alkyl group, and R 3 is an alkylene-heterocycle, said process comprising forming intermediate compound of Formula E1 by reacting, in a refluxing reaction solvent selected from alcohols having 5 or less carbon atoms and mixtures of two or more thereof, a methanol solution of a salt of a 4-alkyl-3-amino-pyrazole compound of Formula C1,n n nwith a diamidization reagent selected from dimethylmalonate, monomethylmalonyl-chloride, and malonyl dichloride in the presence of a Lewis base having sufficient proton affinity to abstract a proton from the 1-position nitrogen on the pyrazole ring.

专利号:US-5783698-A
优先权日:1996-01-23
标题:Chemical synthesis of 1,3-disubstituted quinazolinediones
发明人：SMITH ADRIAN LEONARD
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to a method for the synthesis of 1,3-disubstituted quinazolinedione derivatives which comprises: n (a) reacting a haloformate functionalized polystyrene resin with a substituted anthranilic acid derivative under conditions effective to form a urethane-linkage; n (b) reacting the product of step (a) with a primary amine under conditions effective to form an anthranilamide derivative; n (c) heating the anthranilamide to effect intramolecular cyclization thereby liberating the 1,3-disubstituted quinazolinedione derivative from the resin into solution; and n (d) isolating the 1,3-disubstituted quinazolinedione by filtration and solvent removal.