CAS: 4046-02-0; Ethyl 3-(4-Hydroxy-3-Methoxyphenyl)Acrylate

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CAS号1135-24-6 阿魏酸 | CAS号64-17-5 乙醇 | CAS号6635-27-4 ethyl (E)-3-(4-... | CAS号121-33-5 香草醛 | CAS号1099-45-2 乙基(三苯基膦)乙酸酯 | CAS号97-54-1 异丁香酚(正+反) | CAS号140-88-5 丙烯酸乙酯 | CAS号1071-46-1 丙二酸单乙酯 | CAS号458-35-5 松柏醇 | CAS号20583-78-2 3-(3,4-二甲氧基苯基)丙烯酸乙酯 | CAS号61292-90-8 3-(4-羟基-3-甲氧基苯基)丙酸乙酯 | CAS号1135-24-6 阿魏酸

4-羟基-3-甲氧基苯甲腈置于二异丁基氢化铝体系中,用 N,N-二甲基甲酰胺,甲苯 作为反应溶剂,化学反应生成 阿魏酸乙酯
参考文献:探索苯基丙酸作为游离脂肪酸受体4(ffa4)的激动剂:鉴定口服有效的ffa4激动剂
标题:探索苯基丙酸作为游离脂肪酸受体4(ffa4)的激动剂:鉴定口服有效的ffa4激动剂
摘要:长链游离脂肪酸受体4(ffa4 / Gpr120)最近被认为是脂质传感器,在营养物传感和炎症中起着重要作用,因此具有作为2型糖尿病和代谢综合征的治疗靶标的潜力.为了探索在代谢性疾病动物模型中刺激该受体的作用,我们启动了鉴定具有适当药代动力学特性的激动剂的工作,以支持进入体内研究的进程.对一系列苯丙酸的广泛sar研究导致鉴定出化合物29,一种在两种2型糖尿病临床前模型中降低血浆葡萄糖的ffa4激动剂.
DOI:10.1016/j.Bmcl.2017.01.034

专利信息

专利号:WO-2024222981-A1
优先权日:2023-04-28
标题 :Ester conjugate of sphingolipid and hyaluronan, method of synthesis thereof, composition containing thereof, use of conjugate or composition
发明人：JUHASCIK MARTIN; HUERTA-ANGELES GLORIA; STARMANOVA KATERINA; STEPAN PETR; EXNEROVA ANDREA; NESPOROVA KRISTINA; KOVACIK ANDREJ; BRANDEJSOVA MARTINA; VECEROVA PETRA; POLASKOVA JANA; HERMANNOVA MARTINA; BUFFA RADOVAN; VAGNEROVA HANA; VELEBNY VLADIMIR
权利人:CONTIPRO AS
摘要:The present invention relates to an ester conjugate of sphingolipid and hyaluronan, a composition comprising thereof and its use. Furthermore, it relates to methods of the ester conjugate synthesis.

专利号:US-7618662-B2
优先权日:2004-12-22
标题:Use of natural plant extracts in cosmetic compositions
发明人：HINES MICHELLE D; DUGGAN MICHELE C; BINETTI RALPH R
权利人:AVON PROD INC
摘要:The present invention describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating loss of subcutaneous fat in the skin, wherein the compositions include natural plant constituents that stimulate lipid synthesis. The plant extracts are preferably derived from Rhinacanthus nasutus, Humulus scandens, Sesbania grandiflora, Amorphophallus campanulatu, Pouzolzia pentandra , and Piper betel , and any combinations thereof. The compositions are preferably applied to the skin, or are delivered by directed means, to a site in need thereof.

专利号:US-2012237623-A1
优先权日:2009-12-04
标题 :Topical Compositions Containing Derris Scandens Benth and a Method of Treating Skin
发明人：PTCHELINTSEV DMITRI S; LUO XIAOCHUN
权利人:PTCHELINTSEV DMITRI S; LUO XIAOCHUN; AVON PROD INC
摘要:Topical compositions and methods of use to treat symptoms of reduced skin elasticity are provided comprising extracts of a. Derris scandens Benth. plant. These compositions are effective in stimulating LOXL-1, activity, inhibiting calcineurin activity, and stimulating glycosaminoglycan synthesis in skin cells and can thus reduce age-related skin damage and improve appearance of fine lines, wrinkles, skin sagging and other symptoms of skin aging and/or skin damage.

专利号:US-8575106-B2
优先权日:2009-08-31
标题:Cosmetic uses of modified stressed yeast extracts and related compositions
发明人：SANTHANAM UMA; KYROU CHRISTOS D; MAZICH DESIREE; HONG QI; SHAHEEN HUSSAM H
权利人:SANTHANAM UMA; KYROU CHRISTOS D; MAZICH DESIREE; HONG QI; SHAHEEN HUSSAM H; AVON PROD INC
摘要:Cosmetic compositions comprising a metal-complexed peptide fraction of stressed yeast extracts and/or a calcium influx inhibitor are disclosed, as well as methods of using such compositions to impart exfoliating, anti-aging, anti-lipid, anti-inflammatory, and/or lightening benefits to the skin; and/or lightening benefits to the hair. These compositions are believed to have modulatory activity against at least one biochemical pathway implicated in skin aging, inflammation, lipid synthesis, and melanin production.

专利号:EP-2153815-A1
优先权日:2008-08-05
标题 :Use of urea containing compositions
发明人：TRULLAS CABANAS CARLOS RAMON; KRUTMANN JEAN PROF DR
权利人:ISDIN SA
摘要:The present invention relates to the use of a composition comprising urea for increasing the expression of at least one gene associated with the collagen synthesis within the dermis of the skin. nThe urea composition has been used for preventing/treating damages of the skin such as signs of aging, wrinkles, damages associated with UV-radiation, wounds, skin diseases.

专利号:US-2015366923-A1
优先权日:2013-03-14
标题 :Allamanda cathartica extracts and methods of use
发明人：MEI BING C; LYGA JOHN W
权利人:AVON PROD INC
摘要:Methods of using extracts of Allamanda cathartica to impart benefits to skin and/or improve skin conditions resulting from aging or damaged skin are provided, said methods comprising applying the extacts of Allamanda cathartica in pharmaceutically and cosmetically acceptable formulations to the skin surface, which results in activation of collagen synthesis and leads to skin lightening and anti-wrinkle effects.