CAS: 57946-56-2; 4-Chloro-2-Fluoroaniline

上下游产品

CAS号399-31-5 2-氟乙酰苯胺 | CAS号59280-70-5 4'-氯-2'-氟乙酰苯胺 | CAS号348-54-9 邻氟苯胺 | CAS号106-47-8 对氯苯胺 | CAS号446-30-0 4-氯-2-氟苯甲酸 | CAS号4146-24-1 2-甲基-6-氯苯并噻唑 | CAS号14791-78-7 2-氟苯-1,4-二胺 | CAS号193001-59-1 4-(4-氯-2-氟苯基氨基)... | CAS号23474-98-8 2-氨基-5-氯苯硫酚 | CAS号86988-02-5 2-氟-4-氯-5-硝基苯胺 | CAS号625-98-9 间氯氟苯 | CAS号59280-70-5 4'-氯-2'-氟乙酰苯胺 | CAS号57381-51-8 4-氯-2-氟苯甲腈 | CAS号141337-26-0 4-氯-2-氟苯磺酰氯 | CAS号1996-29-8 1-溴-4-氯-2-氟苯

2-氟苯胺置于copper Dichloride,1-己基-3-甲基咪唑氯化物体系中,化学反应 4.0H,以88%的收率获得产物4-氯-2-氟苯胺
参考文献:Regioselective Chlorination And Bromination Of Unprotected Anilines Under Mild Conditions Using Copper Halides In Ionic Liquids
标题:Regioselective Chlorination And Bromination Of Unprotected Anilines Under Mild Conditions Using Copper Halides In Ionic Liquids
摘要:通过使用离子液体作作为反应溶剂,可以在温和条件下使用铜卤化物在对位对苯胺上实现高产率的氯化或溴化反应,而无需进行潜在危险的操作,如补充氧气或气态hcl.
DOI:10.3762/bjoc.8.84

专利信息

专利号:US-11040938-B2
优先权日:2016-07-27
标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
发明人：MA BING; PAN SHUAI
权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH
摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

专利号:WO-2023086801-A1
优先权日:2021-11-09
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-9018203-B2
优先权日:2012-04-18
标题 :Pharmaceutical composition of salicylanilide-derived small molecules and preparation and application thereof
发明人：CHANG DEH-MING; HUANG HSU-SHAN; CHEN CHUN-LIANG; LEE CHIA-CHUNG
权利人:CHANG DEH-MING; HUANG HSU-SHAN; CHEN CHUN-LIANG; LEE CHIA-CHUNG; NAT DEFENSE MEDICAL CT
摘要:The present invention provides a pharmaceutical composition of salicylanilide-derived small molecules include:n (a) a compound which structure is selected from formula I or formula II: nn n n n n n n n n n n n (b) a pharmaceutically acceptable salt and excipient. The present invention also provides the synthesis method of the pharmaceutical composition and the application thereof.

专利号:US-4517130-A
优先权日:1982-04-22
标 题 :Substituted amino acid process
发明人：BAER TED A
权利人:ZOECON CORP
摘要:An improved process for preparing substituted amino acids and lower alkyl esters thereof, and intermediates therefor, comprising reacting a substituted aniline, HCN and an aldehyde to form a nitrile, converting the nitrile to an imidate salt with a strong acid and an alcohol, hydrolyzing in situ the imidate salt to the ester with addition of water, and optionally converting the ester to the salt or free acid. The acids are useful intermediates in the synthesis of pesticides.

专利号:US-2019152896-A1
优先权日:2016-07-27
标题 :Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts

专利号:CN-101230044-A
优先权日:2008-01-31
标 题:Synthesis of 4-substituted methoxy acrylate-1,2,4-triazolinones derivatives and herbicidal activity