N-乙酰-L-半胱氨酸置于氯化亚砜体系中,用33 %的收率获得产物n-乙酰-L-半胱氨酸乙酯 参考文献:Compounds And Methods For The Treatment Of ocular Disorders 标题:Compounds And Methods For The Treatment Of ocular Disorders 摘要:本文描述了用于治疗或预防眼表面疾病的组合物和方法,包括睑板腺功能障碍,眼睑炎,干眼症和其他前表面炎症和/或感染性眼疾.所述组合物和方法包括角质溶解偶联物,其表现出角质溶解活性和抗炎或其他理想活性.将所述组合物局部给药于眼睑边缘或周围区域,可为患有眼表面疾病的患者提供治疗益处.
专利号:US-2008081082-A1 优先权日:2000-11-21 标题:Topical Skin Compositions, Their Preparation, and Their Use 发明人:ZIMMERMAN AMY C; DEPPA DEBRA J; O'TOOLE DEBORAH A; MAYNE JAMES R 权利人:ACCESS BUSINES GROUP INTERNAT 摘要:Topical skin compositions include a complex containing components to provide a defense against the various pathway mechanisms of free radicals, reactive oxygen species, reactive nitrogen species, and other oxidizing species on the human body including the skin. The compositions may be administered by topically applying them in an amount to inhibit those mechanisms. The compositions and methods are directed to the prevention of the adverse or detrimental effects of free radicals, reactive oxygen species, reactive nitrogen species, and other oxidizing species on the human body including the skin. Thus, the compositions according to the invention improve barrier function, inhibit elastase and collagenase, and/or promote synthesis of collagen and elastin.
专利号:US-2008124409-A1 优先权日:2000-11-21 标题 :Topical Skin Compositions, Their Preparation, and Their Use 发明人:ZIMMERMAN AMY C; DEPPA DEBRA J; O'TOOLE DEBORAH A; MAYNE JAMES R 权利人:ACCESS BUSINESS GROUP INT LLC 摘要:Topical skin compositions include a complex containing components to provide a defense against the various pathway mechanisms of free radicals, reactive oxygen species, reactive nitrogen species, and other oxidizing species on the human body including the skin. The compositions may be administered by topically applying them in an amount to inhibit those mechanisms. The compositions and methods are directed to the prevention of the adverse or detrimental effects of free radicals, reactive oxygen species, reactive nitrogen species, and other oxidizing species on the human body including the skin. Thus, the compositions according to the invention improve barrier function, inhibit elastase and collagenase, and/or promote synthesis of collagen and elastin.
参考文献:10.1038/s41392-023-01603-4 摘要:Cui B, Song L, Wang Q, Li K, He Q, Wu X, Gao F, Liu M, An C, Gao Q, Hu C, Hao X, Dong F, Zhou J, Liu D, Song Z, Yan X, Zhang J, Bai Y, Mao Q, Yang X, Liang Z. Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors. Signal Transduct Target Ther. 2023 Sep 25;8(1):366. 参考文献:10.1038/s41388-024-03025-0 摘要:Bottoni L, Minetti A, Realini G, Pio E, Giustarini D, Rossi R, Rocchio C, Franci L, Salvini L, Catona O, D’Aurizio R, Rasa M, Giurisato E, Neri F, Orlandini M, Chiariello M, Galvagni F. NRF2 activation by cysteine as a survival mechanism for triple-negative breast cancer cells. Oncogene. 2024 Apr 10;43(22):1701–13. doi: 10.1038/s41388-024-03025-0.