CAS: 849052-26-2; Cyclobutylboronic Acid

相似化合物

1360914-08-4 1065010-88-9 2135480-21-4

上下游产品

CAS号1065010-88-9 环丁基三氟硼酸钾 | CAS号328-70-1 1,3-双(三氟甲基)-5-溴苯 | CAS号7732-18-5 水 | CAS号1065010-88-9 环丁基三氟硼酸钾

环丁基三氟硼酸钾置于水体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 环丁基硼酸
参考文献:有机三氟硼酸盐水解:硼酸释放机制和交叉偶联中的酸碱悖论
标题:有机三氟硼酸盐水解:硼酸释放机制和交叉偶联中的酸碱悖论
摘要:有机三氟硼酸钾 (Rbf(3)K) 试剂水解为相应的硼酸 (Rb(Oh)(2)) 已经在它们在铃木宫浦耦合中的应用的上下文中进行了研究.只有当 Rbf(3)K 试剂的水解速率与催化转化率有适当的配合时,这种 Sm 耦合中的"缓慢释放"策略才可行.在这种情况下,硼酸 Rb(Oh)(2) 基本上不会积累,从而最大限度地减少副反应,例如氧化均偶联和原脱硼.研究表明,水解速率(thf,H(2)O,Cs(2)Co(3),55 oc)取决于许多变量,导致一些 Rbf(3)K 试剂产生复杂的溶剂分解曲线.例如,那些基于 Pf-苯基,萘基,呋喃基,发现苄基部分需要酸催化才能有效水解.这种酸碱悖论确保了它们在碱性 Suzuki-Miyaura 偶联条件下缓慢水解.然而,由 Cs(2)Co(3) 引起的 Thf/h(2)O 的部分相分裂,导致本体介质中的 Ph 值较低,导致反应容器的形状,材料,尺寸和搅拌速率
DOI:10.1021/ja300236K

专利信息

专利号:US-2023212216-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins
发明人：MORRIS ALEXANDER REDFERN; SUTOV GRIGORIJ; BRUNE KARL DIETRICH
权利人:GENIE BIOTECH UK LTD
摘要:Site-specific modifications of proteins are desirable in biotechnological applications such as biopharmaceuticals, immunotherapy, vaccines, and are useful in chemical biology. Gluconoylation is a non-enzymatic, covalent, post-translational modification commonly observed on N-terminal His-Tags bearing proteins. We synthesized glucono-1,5-lactone derivatives, including azido variants for selective acylation. High yield acylation is achieved by simply mixing derivatives with target protein amidst diverse conditions of temperatures, aqueous buffers, excipients, or complex cell lysate.

专利号:AU-2020409711-A1
优先权日:2019-12-20
标题 :Synthesis of lactone derivatives and their use in the modification of proteins

专利号:US-10072028-B2
优先权日:2013-11-03
标题:Cross-coupling of unactivated secondary boronic acids
发明人：BURKE MARTIN D; WANG PULIN; CROUCH IAN
权利人:UNIV ILLINOIS
摘要:Provided are methods for site- and stereo-retentive cross-couplings with unactivated secondary boronic acids, which methods are particularly useful in building block-based approach for small molecule synthesis. Also provided is a method of forming an air-stable chiral secondary boronic acid.

专利号:EP-4076533-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins

专利号:CA-3164962-A1
优先权日:2019-12-20
标题 :Synthesis of lactone derivatives and their use in the modification of proteins

专利号:WO-2021123229-A1
优先权日:2019-12-20
标题:Synthesis of lactone derivatives and their use in the modification of proteins