CAS: 14350-97-1; 1H-Imidazolium, 1-[2-(Carboxymethoxy)Ethyl]-1-(Carboxymethyl)-4,5-Dihydro-2-Undecyl-, Hydroxide, Sodium Salt

专利信息

专利号:EP-1406599-B1
优先权日:2001-07-07
标 题 :Cosmetic and dermatological preparations containing creatine for treating and actively preventing dry skin and other negative alterations of the physiological homeostasis of healthy skin
发明人：SAUERMANN GERHARD; SCHREINER VOLKER; DOERING THOMAS; SIEFKEN WILFRIED; GATERMAN CORNELIA; CARSTENSEN STEFANIE; BIERGIESSER HELGA; BLATT THOMAS
权利人:BEIERSDORF AG
摘要:Topical compositions containing creatine and its precursors and derivatives, are used to improve skin condition and to treat or prevent skin disorders, abnormal lipid peroxidation, reduced cell-cell communication, deficient intracellular DNA synthesis, DNA damage, deficient DNA repair, abnormal post-translational modification of connective tissue components and dandruff. Topical compositions comprising creatine and its precursors and derivatives and optionally electrolytes, polyols, urea and osmolytes are used: (1) to treat or prevent dry skin, to enhance the barrier function of the skin, for treatment, care and prophylaxis of sensitive skin and/or for treatment and prophylaxis of symptoms of a negative change in the physiological homeostasis of normal skin; (2) to treat or prevent inflammatory skin conditions, atopic eczema, polymorphic photodermatitis, psoriasis, vitiligo and sensitive, itching or irritated skin; (3) to treat or prevent abnormal lipid peroxidation; (4) to treat or prevent abnormal ceramide, lipid and energy metabolism of the skin, abnormal transepidermal water loss, reduced skin hydration and moisture content and altered Natural Moisturizing Factor content; (5) to treat or prevent reduced cell-cell communication, deficient intracellular DNA synthesis, DNA damage, reduced endogenous DNA repair, activation of metalloproteinases and/or other proteases or inhibition of corresponding DNA repair mechanisms and abnormal post-translational modification of connective tissue components; (6) to treat or prevent abnormal skin hyaluronic acid and glucosaminoglycan content; and (7) to treat or prevent dandruff of the hair and scalp and skin aging.

专利号:US-2004220137-A1
优先权日:2001-07-07
标 题:Cosmetic and dermatological preparations containing osmolytes for the treatment of and active prevention of dry skin and of other negative alterations in the physiological homeostasis of healthy skin
发明人：SAUERMANN GERHARD
摘要:Use of n a) one or more compounds from the group of osmolytes or precursors and derivatives thereof, n b) optionally one or more compounds from the group of electrolytes and n c) optionally one or more compounds from the group formed by polyols and urea, n in preparations (cosmetics, dermatological preparations) to be applied topically for the treatment and active prevention of dry skin and for strengthening the barrier function of the skin, and for the treatment, care and prophylaxis of sensitive skin and/or for the treatment and prophylaxis of the symptoms of a negative change in the physiological homeostasis of healthy skin, in particular deficient, sensitive or hypoactive skin conditions or n deficient, sensitive or hypoactive conditions of skin appendages, inflamed skin conditions, and of atopic eczema, polymorphous photodermatosis, psoriasis, vitiligo, n sensitive, itching or irritated skin, n changes in normal lipid peroxidation, n a change in the ceramide, lipid and energy metabolism of healthy skin, n a change in the physiological transepidermal water loss, n a reduction in skin hydration and decrease in the moisture content of the skin, n change in the natural moisturizing factor content, n reduction in cell-cell communication, n deficiency symptoms of intracellular DNA synthesis, n DNA damage and reduction in endogenous DNA repair mechanisms, n activation of metalloproteinases and/or other proteases or inhibition of the corresponding endogenous DNA repair mechanisms, n deviations from the normal post-translational modifications of connective tissue constituents, n changes in the normal hyaluronic acid and glucosaminoglycan content of healthy skin, dandruff formation by the hair, flaking of the scalp and skin ageing.