CAS: 149849-94-5; Methyl 2-Chloropyrimidine-4-Carboxylate

相似化合物

149849-92-3 34953-87-2 89793-11-3

上下游产品

CAS号6299-85-0 2,6-二氯嘧啶-4-甲酸甲酯 | CAS号149849-93-4 2-氯嘧啶-4-羰基氯

2,6-二氯嘧啶-4-甲酸甲酯置于5%-Palladium/activated Carbon 氢气体系中,用 乙醇 用作溶剂,20.0 °C,250.0 Kpa 条件下,反应 18.0H,以11%的收率获得2-氯嘧啶-4-甲酸甲酯
参考文献:Pyrimidine,Quinazoline,Pteridine And Triazine Derivatives
标题:Pyrimidine,Quinazoline,Pteridine And Triazine Derivatives
摘要:这项发明涉及以下式的化合物 其中a,R1至r5和g如描述和声明中所定义,并其药学上可接受的盐.该发明还涉及含有这种化合物的药物组合物,以及用于制备它们的方法和它们用于治疗和/或预防与调节sst受体亚型5相关的疾病的用途.

专利信息

专利号:US-2010004245-A1
优先权日:2006-10-20
标 题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：OBALLA RENATA M; DESCHENES DENIS; GAGNON MARC; LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-9944644-B2
优先权日:2013-03-14
标 题 :Octahydropyrrolopyrroles their preparation and use
发明人：PETRUKHIN KONSTANTIN; CIOFFI CHRISTOPHER; JOHNSON GRAHAM; DOBRI NICOLETA; FREEMAN EMILY; CHEN PING; CONLON MICHAEL; ZHU LEI
权利人:PETRUKHIN KONSTANTIN; CIOFFI CHRISTOPHER; JOHNSON GRAHAM; DOBRI NICOLETA; FREEMAN EMILY; CHEN PING; CONLON MICHAEL; ZHU LEI; UNIV COLUMBIA
摘要:The present invention provides compounds comprising variously substituted octahydropyrrolopyrroles, their synthesis, methods of making, methods of using, compositions and formulations thereof.