CAS: 16681-56-4; 2-Bromo-1H-Imidazole

该化合物是Iimidazole的溴化衍生物,一种在有机合成和制药研究中广泛使用的杂交环化合物,由于溴替代体的活性作用,该化合物是一个多用途中间体,特别是在准备更复杂的imidazole结构方面,其主要优点包括高纯度和稳定性,适合交叉反应,如Suzuki-Miyaura或Buchwald-Hartwig.在2号位置上存在的溴原子可以选择性地发挥作用,能够准确修改药物发现和材料科学应用,通常用于生物活性分子,催化剂和农用化学的开发,建议在不热条件下进行适当处理以保持其完整性.

结构式图片

相似化合物

1207457-15-5 64591-03-3 101023-55-6

欧盟法规

ECHA物质C&L通报

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CAS号1239205-21-0 2-bromo-N,N-dim... | CAS号288-32-4 咪唑 | CAS号15469-97-3 N-三苯甲基咪唑 | CAS号10035-10-6 氢溴酸 | CAS号937013-66-6 2-(3-溴苯基)咪唑

合成工艺路线路线简述

    2-Bromo-N,N-Dimethyl-1H-Imidazole-1-Sulfonamide置于水,氢溴酸体系中,化学反应 16.0H,反应生成2-溴-1H-咪唑
    参考文献: Pteridinones As Inhibitors Of Polo-Like Kinase[fr] Ptéridinones En Tant Qu'Inhibiteurs De Polo-Like Kinase
    标题: Pteridinones As Inhibitors Of Polo-Like Kinase[fr] Ptéridinones En Tant Qu'Inhibiteurs De Polo-Like Kinase
    摘要:本发明提供了具有如下结构式(I)的化合物或其盐或溶剂化物,其中环a,X,R1,R2,R3,R4,R5和r6的定义如本文所述.本发明还提供了包括本发明化合物的药物组合物以及制造和使用本发明化合物和组合物的方法,例如,在治疗和预防各种疾病,如帕金森病.

    专利信息


    专利号:US-11848117-B2
    优先权日:2017-12-06
    标题:Thin and uniform silver nanowires, method of synthesis and transparent conductive films formed from the nanowires
    发明人:HU YONGXING; LI YING-SYI; YANG XIQIANG; ANG JING SHUN; VIRKAR AJAY
    权利人:C3 NANO INC
    摘要:Highly uniform and thin silver nanowires are described having average diameters below 20 nm and a small standard deviation of the diameters. The silver nanowires have a high aspect ratio. The silver nanowires can be characterized by a small number of nanowires having a diameter greater than 18 nm as well as with a blue shifted narrow absorption spectrum in a dilute solution. Methods are described to allow for the synthesis of the narrow uniform silver nanowires. Transparent conductive films formed from the thin, uniform silver nanowires can have very low levels of haze and low values of ΔL*, the diffusive luminosity, such that the transparent conductive films can provide little alteration of the appearance of a black background.

    专利号:US-2022356182-A1
    优先权日:2009-03-27
    标题 :Inhibitors of hepatitis c virus replication
    发明人:COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
    权利人:MERCK SHARP & DOHME
    摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

    专利号:US-11053243-B2
    优先权日:2009-03-27
    标 题:Inhibitors of hepatitis C virus replication
    发明人:COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
    权利人:MERCK SHARP & DOHME
    摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

    专利号:US-9090661-B2
    优先权日:2009-03-27
    标 题:Inhibitors of hepatitis C virus replication
    发明人:COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN
    权利人:MERCK SHARP & DOHME
    摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

    专利号:CN-117660376-A
    优先权日:2022-09-08
    标题 :A mutant of N-oxygenase used for the synthesis of 2-nitroimidazole and its application

    专利号:CN-113117747-A
    优先权日:2021-04-22
    标题:An interface ionic liquid-supported catalyst for the synthesis of cyclic carbonates from carbon dioxide
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    合成参考文献


    摘要:Molander, G. A.; Ryu, D., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 31.
    摘要:G.B. Barlin. J. Chem. Soc., B 1967, 641.
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