2-Bromo-N,N-Dimethyl-1H-Imidazole-1-Sulfonamide置于水,氢溴酸体系中,化学反应 16.0H,反应生成2-溴-1H-咪唑 参考文献: Pteridinones As Inhibitors Of Polo-Like Kinase[fr] Ptéridinones En Tant Qu'Inhibiteurs De Polo-Like Kinase 标题: Pteridinones As Inhibitors Of Polo-Like Kinase[fr] Ptéridinones En Tant Qu'Inhibiteurs De Polo-Like Kinase 摘要:本发明提供了具有如下结构式(I)的化合物或其盐或溶剂化物,其中环a,X,R1,R2,R3,R4,R5和r6的定义如本文所述.本发明还提供了包括本发明化合物的药物组合物以及制造和使用本发明化合物和组合物的方法,例如,在治疗和预防各种疾病,如帕金森病.
专利信息
专利号:US-11848117-B2 优先权日:2017-12-06 标题:Thin and uniform silver nanowires, method of synthesis and transparent conductive films formed from the nanowires 发明人:HU YONGXING; LI YING-SYI; YANG XIQIANG; ANG JING SHUN; VIRKAR AJAY 权利人:C3 NANO INC 摘要:Highly uniform and thin silver nanowires are described having average diameters below 20 nm and a small standard deviation of the diameters. The silver nanowires have a high aspect ratio. The silver nanowires can be characterized by a small number of nanowires having a diameter greater than 18 nm as well as with a blue shifted narrow absorption spectrum in a dilute solution. Methods are described to allow for the synthesis of the narrow uniform silver nanowires. Transparent conductive films formed from the thin, uniform silver nanowires can have very low levels of haze and low values of ΔL*, the diffusive luminosity, such that the transparent conductive films can provide little alteration of the appearance of a black background.
专利号:US-2022356182-A1 优先权日:2009-03-27 标题 :Inhibitors of hepatitis c virus replication 发明人:COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:US-11053243-B2 优先权日:2009-03-27 标 题:Inhibitors of hepatitis C virus replication 发明人:COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:US-9090661-B2 优先权日:2009-03-27 标 题:Inhibitors of hepatitis C virus replication 发明人:COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:CN-117660376-A 优先权日:2022-09-08 标题 :A mutant of N-oxygenase used for the synthesis of 2-nitroimidazole and its application
专利号:CN-113117747-A 优先权日:2021-04-22 标题:An interface ionic liquid-supported catalyst for the synthesis of cyclic carbonates from carbon dioxide