专利号:US-5486615-A 优先权日:1993-11-30 标题:Method of making asymmetric DE ring intermediates for the synthesis of camptothecin analogs 发明人:COMINS DANIEL L 权利人:UNIV NORTH CAROLINA STATE 摘要:Methods of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs employ a dioxane intermediate as the immediate precursor to the DE ring intermediate. Novel intermediates are also disclosed.
专利号:US-5631384-A 优先权日:1992-09-22 标 题:Areno [e]indols, preparation method and application as intermediates in the synthesis of products with antitumoral activity 发明人:ALEXANDER KOEN; DELAMANO GARCIA JOSE; SAS BENEDIKT; TOJO SUAREZ GABRIEL; GARCIA GRAVALOS DOLORES 权利人:PHARMA MAR S A PHARMAR 摘要:The compounds (I) are useful as intermediates in the synthesis of hexahydroareno(e)cyclopropa(c)indol-4-ones with antitumoral activity.
专利号:US-7964743-B2 优先权日:2005-02-17 标 题:Catalyst for asymmetric synthesis, ligand for use therein, and process for producing optically active compound through asymmetric synthesis reaction using them 发明人:MIYAURA NORIO; YAMAMOTO YASUNORI 权利人:JAPAN SCIENCE & TECH AGENCY 摘要:Compounds represented by the following general formula (1a) or (1b). n nA complex comprising a center metal of rhodium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for optically active beta-substituted carbonyl compound synthesis and catalyst for asymmetric 1, 2 addition reaction being composed of the complex. A method of production of an optically active beta-aryl compound from an alpha, beta-unsaturated compound and an aryl-boronic acid derivative and method of production of an optically active aryl alcohol compound from an aldehyde compound and aryl boronic acid derivatives using the catalyst. A complex comprising a center metal of palladium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for asymmetric allylic substitution reaction being composed of the complex. A method of production of an optically active dialkyl (1,3-disubstituted propeny)malonate compound from a 1,3-disubstituted ally acetate compound and a dialkyl malonate and method of production of an optically active allylamine compound from a 1,3-disubstituted ally acetate compound and an amine compound. The compounds have not only the versatility of being usable in the synthesis of wide-ranging optically active aryl compounds but also the selectivity and reactivity permitting synthesis with high yield within a short period of time under industrially advantageous mild conditions.
专利号:US-7786156-B2 优先权日:2004-01-28 标 题 :Synthesis methods and intermediates for the manufacture of Rizatriptan 发明人:MARTIN PIERRE; BERENS ULRICH; BOUDIER ANDREAS; DOSENBACH OLIVER 权利人:RATIOPHARM GMBH 摘要:The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], n nor a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B]n n nwherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent.n n In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.
专利号:US-7976824-B2 优先权日:2003-07-31 标题:Production of 2-18F-2-deoxy-D-glucose via solid-phase synthesis 发明人:BROWN LYNDA JANE; BROWN RICHARD CHARLES DOWNIE; WADSWORTH HARRY JOHN; JACKSON ALEXANDER 权利人:GE HEALTHCARE LTD 摘要:The invention relates to a compound of formula (I): wherein P 1 , P 2 , P 3 , and P 4 are each independently hydrogen or a protecting group; and n is an integer of from 2 to 20 and to the use of such compounds for the synthesis of 18 F-FDG.
专利号:US-9783634-B2 优先权日:2012-02-15 标题 :Synthesis of photovoltaic conjugated polymers 发明人:WANG SHUANGXI; SHI CHENJUN; CHEN RUBY; ZHANG JUNLIAN; WANG WEI; WU YUE; HUANG HUI; PALKAR AMIT; HE TING 权利人:PHILLIPS 66 CO; SOLARMER ENERGY INC 摘要:A method of making a fluorothieno[3,4-b]thiophene derivatives and photovoltaic polymers containing same using 3-bromothiophene-2-carboxylic acid as a starting material. This synthetic route provides an easier synthesis as well as greater yield and a purer product, which produces superior results over the prior art less pure products. The resulting materials can be used in a variety of photovoltaic applications and devices, especially solar cells.
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 83. 摘要:Huynh, H. V.; Yuan, D., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 27. 摘要:Kopfler FC et al; Adv Environ Sci Technol 8: 419-33 (1977) 摘要:U.S. Department of Transportation. 2012 Emergency Response Guidebook. Washington, D.C. 2012 摘要: