CAS: 33252-63-0; 5-(Trifluoromethyl)Pyridin-2-Ol

相似化合物

175277-45-9 38609-76-6 1227601-04-8

上下游产品

CAS号1163304-58-2 [(C5(CH3)5)IrCl... | CAS号52334-81-3 2-氯-5-三氟甲基吡啶 | CAS号69045-78-9 2-氯-5-三氯甲基吡啶 | CAS号33252-64-1 2-羟基-3-硝基-5-(三氟甲基)吡啶 | CAS号605680-62-4 2-甲基-2-[(5-三氟甲基... | CAS号288246-61-7 2-肼基-3-硝基-5-三氟甲基吡啶 | CAS号701977-09-5 N-[(1S,2S)-3-(4... | CAS号76041-73-1 3-溴-2-羟基-5-三氟甲基砒啶 | CAS号52334-81-3 2-氯-5-三氟甲基吡啶 | CAS号72587-15-6 2-氯-3-硝基-5-(三氟甲基)吡啶 | CAS号201160-48-7 1-Methyl-5-trif... | CAS号89571-66-4 3-amino-5-(trif... | CAS号89571-67-5 3-nitro-5-(trif...

2-氯-5-三氯甲基吡啶置于氢氧化钾,三氟化锑体系中,用 叔丁醇 用作溶剂,化学反应 1.17H,反应生成2-羟基-5-三氟甲基吡啶
参考文献:Haga,Takahiro; Fujikawa,Kan-Ichi; Koyanagi,Tohru,Heterocycles,1984,Vol. 22,# 1,P. 117-124
标题:Haga,Takahiro; Fujikawa,Kan-Ichi; Koyanagi,Tohru,Heterocycles,1984,Vol. 22,# 1,P. 117-124

专利信息

专利号:WO-2025030970-A1
优先权日:2023-08-04
标 题:Condensing agent and use thereof in preparation of isothiocyanate
发明人：SI XIAOJIA; CHEN QUAN; LEI AIWEN; YI HONG; CHEN YI-HUNG
权利人:HUAWEI TECH CO LTD
摘要:The present application relates to the field of organic synthesis. Provided is a condensing agent. The condensing agent has formula 1, wherein R1 and R2 are each independently selected from the same or different electron-withdrawing groups. Compared with thiophosgene or carbon disulfide used in a traditional solution, the condensing agent provided in the embodiments of the present application has lower toxicity, and the condensing agent is a solid, such that the diffusion of pollution is easily controlled. Therefore, the condensing agent provided in the embodiments of the present application can be used for environmentally friendly synthesis of an isothiocyanate compound and has relatively small influence on the environment. Moreover, the condensing agent provided in the embodiments of the present application comprises electron-withdrawing groups, such that the yield of the isothiocyanate compound can be increased.

专利号:US-2023046065-A1
优先权日:2019-11-25
标题 :MERGING C(sp3)-H ACTIVATION WITH DNA-ENCODING
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:Palladium-catalyzed C(sp3)—H arylation of aliphatic carboxylic acids, amides and ketones with BNA-encoded aryl iodides in water is disclosed, Furthermore, sequential C—H arylation chemistry enabled the on-DNA synthesis of structurally-diverse scaffolds containing enriched C(sp3) character, chiral centers, cyclopropane, cyclobutane, and heterocycles. That new chemistry permits preparation of a DNA—encoded library (BEL) technology that can dramatically expedite hit identification in drug discovery owing to its ability to perform protein affinity selection with millions or billions of molecules in a single experiment. The sequential functionalization of multiple C—H bonds provides an unique avenue for creating diversity and complexity from simple starting materials. The use of water as solvent, the presence of DMA, and the extremely low concentration of DMA-encoded coupling partners (0.001 M) have previously hampered the development DMA-encoded C(sp3)—H activation reactions, but many of those hurdles have now been overcome.

专利号:US-3963734-A
优先权日:1971-09-17
标 题:Lower alkylsulfonyl 2-amino, 3-nitro pyridines
发明人：DOHERTY GEORGE O P; FUHR KENNETH H
权利人:LILLY CO ELI
摘要:Substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo-(4,5-b)pyridine compounds useful as herbicides; and intermediates useful in the synthesis of these compounds. In addition to exhibiting herbicidal activity, the substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo(4,5-b)pyridine compounds are of low mammalian toxicity.

专利号:US-4087432-A
优先权日:1974-05-23
标 题 :1H-imidazo(4,5-b)pyridine compounds
发明人：O DOHERTY GEORGE O P; FUHR KENNETH H
权利人:LILLY CO ELI
摘要:Substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo-(4,5-b)pyridine compounds useful as herbicides; and intermediates useful in the synthesis of these compounds. In addition to exhibiting herbicidal activity, the substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo(4,5-b)pyridine compounds are of low mammalian toxicity.

专利号:US-3968116-A
优先权日:1971-09-17
标 题 :1H-imidazo(4,5-b)pyridine compounds
发明人：DOHERTY GEORGE O P; FUHR KENNETH H
权利人:LILLY CO ELI
摘要:Substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo-(4,5-b)pyridine compounds useful as herbicides; and intermediates useful in the synthesis of these compounds. In addition to exhibiting herbicidal activity, the substituted 1-hydroxy-2-(1,1-difluoroalkyl-1H-imidazo(4,5-b)pyridine compounds are of low mammalian toxicity.

专利号:WO-2023168649-A1
优先权日:2022-03-10
标 题 :Method for preparing mefunidone hydrochloride
发明人：WANG XINGWANG; LIN ZHAIWEI; ZHENG QINXIANG
权利人:GUANGZHOU NUCIEN PHARMACEUTICAL CO LTD
摘要:The present invention relates to a method for preparing mefunidone hydrochloride. Compared with the prior art, one synthesis step is omitted, and the yield is improved, wherein the yield of step 3 in the present invention is 90.0%, and the yield of the finished product ZHC-114 is improved by 10%. The present invention further avoids the use of hydrochloric acid, which is more corrosive than HCO 2 H. In addition, due to the improvement in yield, the overall production cost is reduced, the use of hydrochloric acid is avoided, and the environmental protection cost is also reduced.