CAS: 3839-22-3; 2-Cyanobenzoic Acid

上下游产品

CAS号529-19-1 邻甲基苯腈 | CAS号124-38-9 二氧化碳 | CAS号2042-37-7 邻溴苯腈 | CAS号91054-33-0 2-乙酰苯甲腈 | CAS号7468-67-9 2-氰基苯甲醛 | CAS号873-32-5 邻氯苯腈 | CAS号6587-24-2 邻氰基苯甲酸甲酯 | CAS号131-63-5 ammonium 2-(ami... | CAS号6525-45-7 2-氰基苯甲酸乙酯 | CAS号24292-42-0 d,l-α-methylben... | CAS号88-97-1 邻氨基甲酰苯甲酸 | CAS号6525-45-7 2-氰基苯甲酸乙酯 | CAS号6587-24-2 邻氰基苯甲酸甲酯 | CAS号480-91-1 异吲哚啉-1-酮 | CAS号10017-39-7 2-(胺甲基)苯甲酸盐酸盐 | CAS号114772-54-2 4'-溴甲基-2-氰基联苯 | CAS号137863-89-9 缬沙坦烃化物 | CAS号135689-93-9 2'-氰基-4-甲醛基联苯 | CAS号137862-53-4 缬沙坦 | CAS号114772-53-1 2-氰基-4'-甲基联苯

邻羧基苯甲醛置于盐酸羟胺体系中,用 甘油 用作溶剂,化学反应 9.5H,以80%的收率获得2-氰基苯甲酸
参考文献:不含催化剂,高效且一锅操作的方案,以甘油为绿色溶剂由醛合成腈
标题:不含催化剂,高效且一锅操作的方案,以甘油为绿色溶剂由醛合成腈
摘要:我们在本文中描述了新颖,有效且无一锅的无催化剂方案,该方案通过使用甘油中的羟胺盐酸盐作为绿色溶剂,从醛类合成腈.该方案有效地用于将具有吸电子基团和供电子基团的芳族醛以非常好或优异的收率转化为芳基腈.该方法提供了一种非常简单,有效且对环境无害的程序.
Doi:10.1016/j.Tetlet.2017.11.032

专利信息

专利号:US-2021107859-A1
优先权日:2018-04-06
标题 :A process for the synthesis of carbon labeled organic compounds
发明人：AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-8367841-B2
优先权日:2006-09-08
标 题 :Processes for the preparation of 1,2,4-oxadiazole benzoic acids
发明人：ALMSTEAD NEIL G; HWANG PETER SEONGWOO; PINES SEEMON; MOON YOUNG-CHOON; TAKASUGI JAMES J
权利人:PTC THERAPEUTICS INC; ALMSTEAD NEIL G; HWANG PETER SEONGWOO; PINES SEEMON; MOON YOUNG-CHOON; TAKASUGI JAMES J
摘要:Provided herein are processes for the preparation of compounds useful for the treatment, prevention or management of diseases associated with a nonsense mutation. More specifically, provided herein are processes for the synthesis of 1,2,4-oxadiazoles. In particular, provided herein are processes useful for the preparation of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid.

专利号:US-6355490-B1
优先权日:1996-09-13
标题:Attached tags for use in combinatorial chemistry synthesis
发明人：HOCHLOWSKI JILL EDIE; SOWIN THOMAS J; NORBECK DANIEL W; GRILLOT ANNE-LAURE MARIE; SWENSON ROLF E
摘要:The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split synthesis. The process provides for tagging the solid supports with a coding identifier that is attached to the solid support and which can be decoded by infrared or raman spectroscopy when directly attached to the support.

专利号:US-2009215080-A1
优先权日:2005-10-13
标题:Methods for identification of inhibitors of enzyme activity
发明人：SINHA SUKANTO; CHILCOTE TAMIE JO
权利人:ACTIVESITE PHARMACEUTICALS
摘要:The invention discloses compositions and methods of synthesis to create novel ligands and drugs and identifying such compounds as inhibitors of enzyme targets for use in the treatment of clinical disorders, including cancer, infectious diseases, parasitic infestations, neurological disorders, reproductive disorders, inflammatory disorders, circulatory disorders, and metabolic disorders.

专利号:WO-2005113580-A1
优先权日:2004-05-21
标题 :Anticoronviral compounds and compositions, their pharmaceutical uses and materials for their synthesis
发明人：HOFFMAN ROBERT LOUIS; KANIA ROBERT STEVEN; NIEMAN JAMES ANDREW; PLANKEN SIMON PAUL; SMITH GEORGE JOSEPH III
权利人:PFIZER; HOFFMAN ROBERT LOUIS; KANIA ROBERT STEVEN; NIEMAN JAMES ANDREW; PLANKEN SIMON PAUL; SMITH GEORGE JOSEPH III
摘要:The invention relates to methods of inhibiting SARS-related coronavirus viral replication activity comprising contacting a SARS-related coronavirus protease with a therapeutically effective amount of a SARS 3C like protease inhibitor of formula (I), and compositions comprising the same.