CAS: 39262-14-1; (2S,3R,4S,5S,6R)-2-(((S)-2-((3S,5R,8R,9R,10R,12R,13R,14R,17S)-3,12-Dihydroxy-4,4,8,10,14-Pentamethylhexadecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)-6-Methylhept-5-En-2-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol
该化合物是一种天然化合物,主要来自人参,以其药性著称的植物,主要产自人参;它是许多人参的天然化合物之一,被认为是有助于人参健康利益的活跃成分.金辛诺赛德K的特点是其复杂的分子结构,包括一种类固醇的脊椎,附着各种糖糖味,该化合物以其潜在的药理效应而著称,包括抗炎,抗氧化剂和...
- 英文名称(2S,3R,4S,5S,6R)-2-(((S)-2-((3S,5R,8R,9R,10R,12R,13R,14R,17S)-3,12-Dihydroxy-4,4,8,10,14-Pentamethylhexadecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)-6-Methylhept-5-En-2-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol
- 中文名称人参皂苷CK
- IUPAC名称(2S,3R,4S,5S,6R)-2-(((S)-2-((3S,5R,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-methylhept-5-en-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
- 其它别名20(S)-Protopanaxadiol 20-O-D-glucopyranoside; 20(S)-Protopanaxadiol 20-O-b-D-glucopyranoside; 20-O-b-D-Glucopyranosyl-20(S)-protopanaxadiol; 20-O-b-Glucopyranosyl-20(S)-protopanaxadiol; Ginsenoside C-K; GinsenosideK; Ginsenoside compound K; Protopanaxadiol 20-O-glucoside
- CAS编号39262-14-1
- MFCD编号:MFCD07772261
- EINECS号:683-216-3
- FDA UNII编号:G8D4792Q7K
- 分子式:C36H62O8
- 分子量:622.88
- 产品CID: 1404880
- 产品分类生物化工 → 提取物
- 相似结构搜索
- InChIKey: FVIZARNDLVOMSU-IRFFNABBSA-N
- FVIZARNDLVOMSU-SFEJUJENNA-N…
- 计算化学: 氢键受体数8.0氢键供体数6.0可旋转键数7.0
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号41753-43-9 人参皂苷Rb1 | CAS号6892-79-1 Folienetriol | CAS号51116-90-6 12β,20-Dihydrox... | CAS号108181-53-9 20-O-(2,3,4,6-t...合成工艺路线路线简述
- 合成目标产物 Ginsenoside Ck 主要起始原料 Folienetriol
- 11021-13-9 = 39262-14-1 + 83480-64-2 + 83480-65-3
反应条件:1.1 Catalysts: Ginsenoside Glycosidase Solvents: Water; 120 Min,Ph 5.0,45 °C1.2 Reagents: 1-Butanol Solvents: Water
标题:Biotransformation Pathway And Kinetics Of The Hydrolysis Of The 3-O- And 20-O-Multi-Glucosides Of Ppd-Type Ginsenosides By Ginsenosidase Type I
作者:Liu,Chunying; Et Al
参考文献:Process Biochemistry (Oxford 日期:2014 卷标:49(5) 页码:813-820]
41753-43-9 = 39262-14-1 + 62025-49-4 + 80321-69-3 + 30636-90-9
反应条件:1.1 Reagents: Glucose Catalysts: Glucosidase,β- Solvents: Water; 72 H,37 °C
标题:Enzymatic Transformation Of Ginsenoside Rb1 By Lactobacillus Pentosus Strain 6105 From Kimchi
作者:Kim,Se-Hwa; Et Al
参考文献:Journal Of Ginseng Research 日期:2012 卷标:36(3) 页码:291-297]
68406-26-8 = 39262-14-1 + 80321-63-7 + 62025-49-4 + 52705-93-8 + 80325-22-0
反应条件:1.1 Catalysts: Ginsenoside Glycosidase Solvents: Water; 120 Min,Ph 5.0,45 °C1.2 Reagents: 1-Butanol Solvents: Water
标题:Biotransformation Pathway And Kinetics Of The Hydrolysis Of The 3-O- And 20-O-Multi-Glucosides Of Ppd-Type Ginsenosides By Ginsenosidase Type I
作者:Liu,Chunying; Et Al
参考文献:Process Biochemistry (Oxford 日期:2014 卷标:49(5) 页码:813-820]
41753-43-9 = 39262-14-1 + 110261-98-8 + 62025-49-4 + 52705-93-8 + 80321-69-3
反应条件:1.1 Catalysts: Ginsenoside Glycosidase Solvents: Water; 100 Min,Ph 5.0,45 °C1.2 Reagents: 1-Butanol Solvents: Water
标题:Biotransformation Pathway And Kinetics Of The Hydrolysis Of The 3-O- And 20-O-Multi-Glucosides Of Ppd-Type Ginsenosides By Ginsenosidase Type I
作者:Liu,Chunying; Et Al
参考文献:Process Biochemistry (Oxford 日期:2014 卷标:49(5) 页码:813-820]
41753-43-9 = 39262-14-1 + 62025-49-4 + 52705-93-8 + 80321-69-3 + 30636-90-9
反应条件:1.1 Reagents: (+)-Lactose Catalysts: Glucosidase,β- Solvents: Water; 72 H,37 °C
标题:Enzymatic Transformation Of Ginsenoside Rb1 By Lactobacillus Pentosus Strain 6105 From Kimchi
作者:Kim,Se-Hwa; Et Al
参考文献:Journal Of Ginseng Research 日期:2012 卷标:36(3) 页码:291-297
人参皂甙 反应生成 人参皂苷ck
参考文献:J. Agric. Food Chem. 2007,55,1993-1998
标题:J. Agric. Food Chem. 2007,55,1993-1998
专利信息
专利号:US-2023399688-A1
优先权日:2015-08-20
标 题 :Compositions and multiplexed systems for coupled cell-free transcription-translation and protein synthesis and methods for using them
发明人：CULLER STEPHANIE; CHEN IHSIUNG BRANDON; PHARKYA PRITI; VAN DIEN STEVE; BARTON NELSON
权利人:GENOMATICA INC
摘要:In alternative embodiments, provided herein are transcription/translation (TX-TL) systems and methods of using them for use as rapid prototyping platforms for the synthesis, modification and identification of natural products (NPs), and natural product analogs (NPAs) and secondary metabolites, from biosynthetic gene cluster pipelines. In alternative embodiments, exemplary TX-TL systems as provided herein are used for the combinatorial biosynthesis of natural products (NPs), natural product analogs (NPAs) and secondary metabolites. In alternative embodiments, exemplary TX-TL systems as provided herein are used for the rapid prototyping of complex biosynthetic pathways as a way to rapidly assess combinatorial and biosynthetic designs before moving to cellular hosts. In alternative embodiments, these exemplary TX-TL systems are multiplexed for high-throughput (HT) automation and for prototyping engineered platforms for the synthesis or modification of natural products (NPs), and natural product analogs (NPAs) and secondary metabolites analogs.
专利号:US-2023381213-A1
优先权日:2022-05-31
标题 :Synthesis and uses of ginsenoside compound k derivatives
发明人：CHE CHI-MING; LIU YUNGEN; HE JILIN; LOK CHUN-NAM
权利人:UNIV HONG KONG; LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
摘要:A nontoxic anticancer compound is a derivative of 20-O-β-(D-glucopyranosyl)-20(S)-protopanaxadiol (CK) having at least one of the glucose hydroxyl groups replaced with at least one acetal group. The derivative enhances binding to a mitochondrial membrane protein and is more cytotoxic to cancerous cells than CK. The derivative can be an acetal of an unsubstituted or substituted aromatic group, such as an acetal formed from a substituted 1-(dimethoxymethyl)-benzene. One or more of the CK derivative (CKD) anticancer compounds can be used as an active portion of an anticancer medicament.
专利号:CN-106701647-A
优先权日:2016-09-27
标题 :Application of Gynostemma Gynostemma Glycosyltransferase in the Synthesis of Rare Ginsenosides
专利号:CN-116425813-A
优先权日:2023-01-31
标 题:Stereoselective Synthesis of β-Oxoglycosides from 3-O-quinallidinic Acid Enyl Sugar Donors
专利号:CN-114480323-A
优先权日:2020-11-11
标 题:Avena Glycosyltransferase AsUGT73E1 and Its Application in the Synthesis of Steroidal Saponins
专利号:CN-114480322-A
优先权日:2020-11-11
标题 :Oat glycosyltransferase AsUGT73E5 and application thereof in synthesis of steroid saponin
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主要参考文献
1. Jung, I.-H., Lee, J.H., Hyun, Y.-J., et al. Metabolism of ginsenoside Rb1 by human intestinal microflora and cloning of Its metabolizing β-D-glucosidase from Bifidobacterium longum H-1. Biol. Pharm. Bull. 35(4), 573-581 (2012). 2. Ming, Y., Z., C., Chen, L., et al. Ginsenoside compound K attenuates metastatic growth of hepatocellular carcinoma, which Is associated with the translocation of nuclear factor-κB p65 and reduction of matrix metalloproteinase-2/9. Planta Med. 77(5), 428-433 (2011). 3. Chen, J., Wang, Q., Wu, H., et al. The ginsenoside metabolite compound K exerts its anti-inflammatory activity by downregulatingmemory B cell in adjuvant-induced arthritis. Pharm. Biol. 54(7), 1280-1288 (2016). 4. Zong, W., Zeng, X., Chen, S., et al. Ginsenoside compound K attenuates cognitive deficits in vascular dementia rats by reducing the Aβ deposition. J. Pharmacol. Sci. 139(3), 223-230 (2019).合成参考文献
参考文献:10.1038/s41592-019-0358-2]
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