CAS: 4165-96-2; 3-Phenylglutaric Acid

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5-phenyl-cyclohexane-1,3-dione cinnamonitrile sodium diethylmalonate sodium diethylmalonate 3-phenylglutaric acid anhydride 4-phenylpiperidine-2,6-dione 3-(4-bromophenyl)pentanedioic acid 2-(3-oxo-2,3-dihydro-1H-inden-1-yl)acetic acid

亚苯甲基丙二酸二乙酯置于三氯化铝,氢溴酸体系中,化学反应 54.0H,反应生成 3-苯基戊二酸
参考文献:Synthesis,Screening,And Molecular Modeling Of New Potent And Selective Antagonists At The α1D Adrenergic Receptor
标题:Synthesis,Screening,And Molecular Modeling Of New Potent And Selective Antagonists At The α1D Adrenergic Receptor
摘要:In The Present Study,More Than 75 Compounds Structurally Related To Bmy 7378 Have Been Designed And Synthesized. Structural Variations Of Each Part Of The Reference Molecule Have Been Introduced,Obtaining Highly Selective Ligands For The Aid Adrenergic Receptor. The Molecular Determinants For Selectivity At This Receptor Are Essentially,Held By The Phenyl Substituent In The Phenylpiperazine Moiety. The Integration Of An Extensive Sar Analysis With Docking Simulations Using The Rhodopsin-Based Models Of The Three Alpha(1)-Ar Subtypes And Of The 5-Ht1A Receptor Provides Significant Insights Into The Characterization Of The Receptor Binding Sites As Well As Into The Molecular Determinants Of Ligand Selectivity At The Alpha(1D)-Ar And The 5-Ht1A Receptors. The Results Of Multiple Copies Simultaneous Search (Mcss) On The Substituted Phenylpiperazines Together With Those Of Manual Docking Of Compounds Ban 7378 And 69 Into The Putative Binding Sites Of The Alpha(1A)-Ar,Alpha(1B)-Ar,Alpha(1D)-Ar,And The 5-Ht1A Receptors Suggest That The Phenylpiperazine Moiety Would Dock Into A Site Formed By Amino Acids In Helices 3,4,5,6 And Extracellular Loop 2,(E2),Whereas The Spirocyclic Ring Of The Ligand Docks Into A Site Formed By Amino Acids Of Helices 1,2,3,And 7. This Docking Mode Is Consistent With The Sar Data Produced In This Work. Furthermore,The Binding Site Of The Imide Moiety Does Not Allow For The Simultaneous Involvement Of The Two Carbonyl Oxygen Atoms In H-Bonding,Interactions,Consistent With The Sar Data,In Particular With The Results Obtained With The Lactam Derivative 128. The Results Of Docking Simulations Also Suggest That The Second And Third Extracellular Loops May Act As Selectivity Filters For The Substituted Phenylpiperazines. The Most Potent And Selective Compounds For Alpha(1D) Adrenergic Receptor,I.E.,69 (Rec 26D/038) And 128 (Rec 26D/073),Are Characterized By The Presence Of The 2,5-Dichlorophenylpiperazine Moiety.
DOI:10.1021/jm030944+

专利信息

专利号:WO-2025124564-A1
优先权日:2023-12-15
标题:Polyester synthesis based on aspartic acid modification
发明人：ZHANG KECHUN; CHEN XI; LEI TENGFEI; LIU SHENGYANG
权利人:MINT BIOTECHNOLOGIES CO LTD
摘要:Provided in the present invention is polyester synthesis based on aspartic acid modification. A monomer of a unique structure of an imide ring is obtained based on aspartic acid and a dibasic acid likely to be cyclized, the monomer is based on the aspartic acid, can be derived from biomass, is low in cost and renewable, meets the requirement of sustainable development, and the unique structure of the monomer can regulate and control various properties of polyester materials, such as the mechanics, temperature resistance, hydrophilicity and hydrophobicity, and crystallization.

专利号:CN-117550943-A
优先权日:2023-06-08
标 题:A method for the controllable synthesis of polycarboxylic acid compounds based on CO2 participation

专利号:WO-2025108371-A1
优先权日:2023-11-24
标题 :Copolymer with improved strength and preparation method therefor
发明人：ZHANG KECHUN; LEI TENGFEI; CHEN XI; LIU SHENGYANG
权利人:MINT BIOTECHNOLOGIES CO LTD
摘要:The present invention belongs to the technical field of polymer synthesis. Disclosed are a copolymer and a preparation method therefor. The copolymer comprises a polymer main body structural unit and a structural unit for improving polymer strength, wherein a side chain group of the structural unit for improving the polymer strength contains an imide ring structure (R-0): (R-0), where R1 is the residue of an easily cyclized dibasic acid.

专利号:WO-9303045-A1
优先权日:1991-08-09
标题 :Process for purer organic metal ion chelate complexes
发明人：WHITE DAVID L; EASON ROBERT G
权利人:UNIV CALIFORNIA
摘要:The present invention describes a synthesis and purification of novel organic chelate metal ion (II) or (III) complexes. These processes are useful specifically for producing purer complexes for magnetic resonance imaging (MRI) contrast agents. The metal ion is first complexed, contacted with a water insoluble adsorption resin to adsorb the complex, washed with water to remove dissolved solids, contacted with a water soluble organic coupling agent and an organic diacid, acid amide, or acid ester, separating the solid resin, washing it with water, contacting the resin with polar non-aqueous organic liquid to desorb the complex followed by purification of the desorbed organic chelate metal ion complex. Similarly, preformed organic chelate metal ion complexes can be purified by contacting an aqueous slurry of organic resin followed by the described purification and separation steps.

专利号:CN-112794862-A
优先权日:2019-11-14
标 题:Synthesis and anti-tumor application of long-carbon-chain phenyl dicarboxylic acid based binuclear copper complex