CAS: 446292-10-0; (S)-4-(4-(5-(Aminomethyl)-2-Oxooxazolidin-3-yl)Phenyl)Morpholin-3-One

上下游产品

2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione 2-((2S)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione 4-(4-aminophenyl)morpholin-3-one 2-Anilinoethanol Rivaroxaban N,N'-bis[{(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl]urea N,N'-bis[{(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl]benzene-1,2-diamide

N-[4-(3-氧代-4-吗啉)苯基]氨基甲酸苯基甲酯置于吡啶,盐酸羟胺,Lithium Tert-Butoxide体系中,用 四氢呋喃,甲醇,乙醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 30.0H,反应生成 4-[4-[(5S)-5-(氨甲基)-2-羰基-3-唑烷基]苯基]-3-吗啡啉酮
参考文献: Processes For The Preparation Of 5-Chloro-N-({(5S)-2-Oxo-3-[4-(3-Oxo-4-Morpholinyl) Phenyl]-1,3-Oxazolidin-5-Yl}Methyl)-2-Thiophene-Carboxamide And Intermediates Thereof[fr] Procédés De Préparation Du 5-Chloro-N-({(5S)-2-Oxo-3-[4-(3-Oxo-4-Morpholinyl) Phényl]-1,3-Oxazolidin-5-Yl}Méthyl)-2-Thiophène-Carbomaxide Et De Ses Intermédiaires
标题: Processes For The Preparation Of 5-Chloro-N-({(5S)-2-Oxo-3-[4-(3-Oxo-4-Morpholinyl) Phenyl]-1,3-Oxazolidin-5-Yl}Methyl)-2-Thiophene-Carboxamide And Intermediates Thereof[fr] Procédés De Préparation Du 5-Chloro-N-({(5S)-2-Oxo-3-[4-(3-Oxo-4-Morpholinyl) Phényl]-1,3-Oxazolidin-5-Yl}Méthyl)-2-Thiophène-Carbomaxide Et De Ses Intermédiaires
摘要:本发明提供了用于制备5-氯-N-({(5S)-2-氧代-3-[4-(3-氧代-4-吗啉基)苯基]-1,3-噁唑烷-5-基}甲基)-2-噻吩甲酰胺(I)及其中间体的方法.还提供了新型中间体及其在噁唑烷衍生物合成中的应用.

专利信息

专利号:US-11891384-B2
优先权日:2017-01-04
标题:Process for the preparation of Rivaroxaban involving novel intermediate
发明人：SATHE DHANANJAY G; DAS ARIJIT; Raikar Sanjay; SURVE YASHWANT S; PANDIT BHUSHAN S
权利人:UNICHEM LAB LTD
摘要:The present invention relates to the novel key intermediate, 4-{4-[(SS)-(Aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]-phenyl}-morpholin-3-one perchlorate, m the synthesis of rivaroxaban. The invention further relates to the crystalline form of novel intermediate, the process to prepare the novel intermediate and method of preparing rivaroxaban using this novel intermediate. The invention provides an improved and efficient process for preparation of Rivaroxaban.

专利号:WO-2013046211-A1
优先权日:2011-09-27
标 题 :Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide and intermediates thereof
发明人：MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
权利人:SYMED LABS LTD; MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
摘要:TThe present invention provides processes for the preparation of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide (I) and intermediates thereof. Also provides novel intermediates and their use in the synthesis of oxazolidine derivatives.

专利号:WO-2013027225-A1
优先权日:2011-08-19
标 题:Processes for the preparation of 4-{4-[5(s)-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl} morpholin-3-one
发明人：MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
权利人:SYMED LABS LTD; MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
摘要:The present invention provides simple, eco-friendly, cost-effective, reproducible, robust and industrial processes for the preparation of intermediate compound 4-{4-[5(S)-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one (II). The present invention also provides novel intermediates and their use in the synthesis of morpholinone oxazolidine derivatives.

专利号:WO-2015198259-A1
优先权日:2014-06-26
标 题:Process for the synthesis of rivaroxaban and intermediate for the production thereof
发明人：FERRARI MASSIMO; GHEZZI EMANUELE; GHEZZI MARCELLO
权利人:ERREGIERRE SPA
摘要:A process is described for the production of Rivaroxaban, a compound having the following structural formula: (I) by means of obtaining a novel intermediate of said process.

专利号:CN-103145698-B
优先权日:2013-03-01
标题:A kind of preparation method of Rivaroxaban intermediate and the novel synthesis of razaxaban

专利号:RU-2383540-C2
优先权日:2004-01-15
标 题 :Method for synthesis of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide