CAS: 50-84-0; 2,4-Dichlorobenzoic Acid

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CAS号1777-82-8 2,4-二氯苄醇 | CAS号95-73-8 2,4-二氯甲苯 | CAS号874-42-0 2,4-二氯苯甲醛 | CAS号32768-54-0 2,3-二氯甲苯 | CAS号650598-43-9 2-溴-4,6-二氯苯甲酸 | CAS号2234-16-4 2,4-二氯苯乙酮 | CAS号124-38-9 二氧化碳 | CAS号29898-32-6 2,4-二氯-1-碘苯 | CAS号650598-47-3 2,4-dichloro-3-... | CAS号38154-43-7 4,7-二氯-2-甲基喹唑啉 | CAS号50-82-8 2,4,5-三氯苯甲酸 | CAS号3698-83-7 1,3-二氯-4,6-二硝基苯 | CAS号52729-03-0 2,4-二氯-3,5-二硝基苯甲酸 | CAS号5106-98-9 4-氯水杨酸 | CAS号56363-84-9 2-氯-4-羟基苯甲酸 | CAS号35112-28-8 2,4-二氯苯甲酸甲酯 | CAS号57479-70-6 2-甲氧基-4-氯苯甲酸 | CAS号14225-79-7 1H-Benzimidazol... | CAS号40183-55-9 2-(Benzylsulfan...

2-溴-4,6-二氯苯甲酸置于锌体系中,用 Sodium Hydroxide 作为反应溶剂,化学反应 2.0H,以98%的收率获得产物2,4-二氯苯甲酸
参考文献:支撑效应改变 1,3-二氯苯和 1,3-二溴苯的去质子化和功能化
标题:支撑效应改变 1,3-二氯苯和 1,3-二溴苯的去质子化和功能化
摘要:1,3-二氟苯,1,3-二氯苯和 1,3-二溴苯之间的系统比较并未揭示它们对强碱(如二异丙基氨基锂或 2,2,6,6-四甲基哌啶锂)行为的重大差异.因此,通过用合适的碱和干冰连续处理,所有 2,6-二卤代苯甲酸都可以直接获得.相比之下,(2,6-二氯苯基)-和(2,6-溴苯基)三乙基硅烷在 5-位进行去质子化(提供 4-羧基衍生物和脱保护后的 3,5-二卤代苯甲酸),而 1已知,3-二氟类似物在 4-位反应.2,4-二卤代苯甲酸被选择性地制备.从硅烷通过在 4 位溴化,相邻位置的金属化和羧化,然后脱甲硅烷基化和脱溴或 1,3-Dihalo-2-Iodobenzos 通过碱促进碘迁移到 4 位,然后碘/镁置换和随后的羧化.[在 Scifinder (R) 上]
DOI:10.1002/ejoc.200300355

专利信息

专利号:US-5783698-A
优先权日:1996-01-23
标题:Chemical synthesis of 1,3-disubstituted quinazolinediones
发明人：SMITH ADRIAN LEONARD
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to a method for the synthesis of 1,3-disubstituted quinazolinedione derivatives which comprises: n (a) reacting a haloformate functionalized polystyrene resin with a substituted anthranilic acid derivative under conditions effective to form a urethane-linkage; n (b) reacting the product of step (a) with a primary amine under conditions effective to form an anthranilamide derivative; n (c) heating the anthranilamide to effect intramolecular cyclization thereby liberating the 1,3-disubstituted quinazolinedione derivative from the resin into solution; and n (d) isolating the 1,3-disubstituted quinazolinedione by filtration and solvent removal.

专利号:WO-2024061842-A1
优先权日:2022-09-19
标 题:Improved oligonucleotide synthesis
发明人：CREUSEN GUIDO; MINUTH MARCO; SAMSON DANIEL
权利人:BACHEM HOLDING AG
摘要:A method for the solid-phase synthesis of a target oligonucleotide OT is disclosed, wherein said method comprises a step of incubating a nucleoside or oligonucleotide, which is covalently linked to a solid support and comprises a backbone hydroxyl moiety protected by a di(p-methoxyphenyl)phenylmethyl (DMT) protecting group, with a deprotection mixture, thereby cleaving said protecting group from said nucleoside or oligonucleotide, wherein said deprotection mixture is a liquid composition comprising a solvent, a protic acid having a pKa equal to or smaller than 4, and at least one alcohol of Formula (D), wherein in RD-1 R,D-2 R,D-3 RD-4 and RD-5 are indepently of each other selected from the group consisting of H, OH, a e1-e6-alkyl group, O(C1-C6-aIkyl), C(O)(Ci-C6-alkyl), C(O)O(Ci-C6-alkyl), F, Cl, Br, I, and CN. Such a method does not only suppress depurination, but also results in an acceptable product yield.

专利号:US-6180830-B1
优先权日:1995-11-08
标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes
发明人：JACQUOT ROLAND
权利人:RHODIA CHIMIE SA
摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.

专利号:US-2024417358-A1
优先权日:2021-10-04
标题:Continuous Flow Reactor and Process for Synthesis of Substituted Benzoic Acid
发明人：JOSHI SUNIL SHANKAR; MALI NILESH ATMARAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention provides a non-hazardous, improved continuous oxidation process for the preparation of substituted benzoic acid of formula (I) by using continuous process reactor system with improved process controls. (I) wherein: R 1 is H, F, Cl, Br, I, NO 2 , amine, or C 1 -C 5 alkyl; R 2 is H, F, Cl, Br, I, NO 2 , amine, or C 1 -C 5 alkyl; and R 3 is H, F, Cl, Br, I, NO 2 , amine, C 1 -C 5 alkyl;

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-5231198-A
优先权日:1992-07-06
标题:Asymmetric synthesis of hexahydrodibenzofurans by stereospecific inversion of ortho substituted 2-phenylcyclohexanols
发明人：POWERS MATTEW R; GOLEC FREDERICK A
权利人:RHONE POULENC RORER PHARMA
摘要:This invention relates to the stereospecific process for the preparation, separation and purification of hexahydrodibenzofurans which are used in the preparation of the 5HT 3 compounds. More specifically, the present invention relates to a process for the preparation of substantially optically pure cishexahydrodibenzofuran compounds including at least two chiral fused ring centers which comprises the acidic catalyzed stereospecific ring closure by the intra-molecular inversion of a gamma, i.e. 2', carbon atom of a 2-[(2'-leaving group)cycloalkyl]phenol.