CAS: 533-30-2; 6-Aminobenzothiazole

该化合物是一种有机化合物,其特征为:一个有氨基质的苯并氧环状结构,在6点位置,它看起来像一个黄到浅褐色的固体,以其杂交循环性质而著称,它有助于其化学反应和潜在应用;该化合物在有机溶剂中溶解,但在水中溶解性有限,反映了其疏水特性. 6-Aminobeotherothothozeole主要用于合成各种染料,药品和农用化学品,因为它能够参与多种化学反应,包括核球菌替代和混合反应.此外,它展示了生物活动,使其对药用化学感兴趣,以用于潜在的治疗用途.安全考虑很重要,因为它如果不得到适当处理,可能会对健康造成危害,因此需要在其使用和储存期间采取适当的安全措施.总的来说,6-Aminobeothozeozeozeol是具有重大工业和研究相关性的多种化合物.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

6-硝基苯并噻唑 6-Nitrobenzo[d]Thiazole 05/06/2942
苯并噻唑 1,3-Benzothiazole 95-16-9
2-氨基-6-硝基苯并噻唑 2-Amino-6-Nitrobenzothiazole 6285-57-0
2-氯-6-硝基苯并噻唑 2-Chloro-6-Nitrobenzothiazole 06/11/2407
2-氟-6-硝基-1,3-苯并噻唑 2-Fluoro-6-Nitro-Benzothiazole 1131-75-5
6-硝基-2-苯并噻唑啉酮 6-Nitro-2(3H)-Benzothiazolone 28620-12-4
6-溴苯并噻唑 6-Bromo-1,3-Benzothiazole 53218-26-1

合成工艺路线路线简述

    2-氯-6-硝基苯并噻唑置于盐酸,Tin,溶剂黄146体系中,化学反应生成 6-氨基苯并噻唑
    参考文献:Nishizawa,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1942,Vol. 62,P. 47,51; Dtsch. Ref. S. 19,22
    标题:Nishizawa,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1942,Vol. 62,P. 47,51; Dtsch. Ref. S. 19,22

    专利信息


    专利号:WO-2024129887-A1
    优先权日:2022-12-13
    标题:Biobased synthesis of glucodiamine
    发明人:MILLET AGUSTIN; WOELK HANS-JOERG; LEE TONI M; CHAKRABARTI GAURAB; HUNT SEAN
    权利人:SOLUGEN INC
    摘要:A method of preparing glucodiamine, comprising contacting glucose with an enzyme oxidation catalyst under conditions suitable for the formation of glucodialdose; contacting glucodialdose with a nitrogen-containing compound under conditions suitable for the formation of glucodioxime; and reducing glucodioxime under conditions suitable for the formation of glucodiamine. A method of preparing glucodiamine, comprising contacting glucodioxime with a dehydration catalyst under conditions suitable for the formation of glucodinitrile; and reducing glucodinitrile under conditions suitable for the formation of glucodiamine. A chemoenzymatic method of producing a bio-based amide platform chemical, comprising: contacting glucose with a biocatalyst under conditions suitable for the formation of glucodialdose; contacting glucodialdose with a base under conditions suitable for the formation of glucodioxime; and contacting glucodioxime with a hydrogenation catalyst in the presence of hydrogen under conditions suitable for formation of glucodiamine.

    专利号:US-6849650-B2
    优先权日:1998-02-27
    标 题:Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
    发明人:THORSETT EUGENE D; PORTER WARREN J; NISSEN JEFFREY S; LATIMER LEE H; AUDIA JAMES E; DROSTE JAMES
    权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
    摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

    专利号:US-6399628-B1
    优先权日:1996-11-22
    标 题 :N-(aryl/heteroaryl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting alpha- amyloid peptide release and/or its synthesis by use of such compounds
    发明人:AUDIA JAMES E; FOLMER BEVERLY K; JOHN VARGHESE; LATIMER LEE H; NISSEN JEFFREY S; REEL JON K; THORSETT EUGENE D; WHITESITT CELIA A
    权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
    摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

    专利号:US-6495693-B2
    优先权日:1996-11-22
    标题:N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
    发明人:AUDIA JAMES E; FOLMER BEVERLY K; JOHN VARGHESE; LATIMER LEE H; NISSEN JEFFREY S; PORTER WARREN J; THORSETT EUGENE D; WU JING
    权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
    摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

    专利号:EP-0951466-B1
    优先权日:1996-12-23
    标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
    发明人:WU JING; TUNG JAY S; THORSETT EUGENE D; PLEISS MICHAEL A; NISSEN JEFFREY S; NEITZ JEFFREY; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; DROSTE JAMES J; HENRY STEVEN S; MCDANIEL STACEY L; SCOTT WILLIAM L; STUCKY RUSSELL D
    权利人:ELAN PHARM INC; LILLY CO ELI
    摘要:Disclosed are compounds for Formula (I) wherein the substituents are as defined in the claims which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

    专利号:US-7390801-B2
    优先权日:1996-12-23
    标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
    发明人:THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
    权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
    摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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    合成参考文献


    摘要:Lai, J.; Thomson, B. J.; Sammis, G. M., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 6.
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