3-甲基-2-溴苄溴置于盐酸,Potassium Permanganate,乌洛托品体系中,用 水,丙酮 作为反应溶剂,化学反应 3.0H,反应生成 2-溴-3-甲基苯甲酸 参考文献:Selective Oxidation Of 2-Bromo-M-Xylene To 2-Bromo-3-Methylbenzoic Acid Or 2-Bromoisophthalic Acid 标题:Selective Oxidation Of 2-Bromo-M-Xylene To 2-Bromo-3-Methylbenzoic Acid Or 2-Bromoisophthalic Acid 摘要:在水性重铬酸钠氧化及二氧化碳压力下,2-溴间二甲苯(1)反应生成2-溴异酞酸(产率58%),而经过nbs溴化后再经sommelet氧化为醛,随后用高锰酸钾氧化,则成功分离出产率为42%的2-溴-3-甲基苯甲酸. DOI:10.1246/bcsj.59.3285
专利号:US-7968752-B2 优先权日:2003-06-16 标 题:Hydrolytically-resistant boron-containing therapeutics and methods of use 发明人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A 权利人:ANACOR PHARMACEUTICALS INC 摘要:Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
专利号:CN-119285635-A 优先权日:2024-11-06 标题 :Synthesis of 8H-indolo [3,2,1-DE ] phenanthridine-8-ketone compound from carbazole and o-bromobenzoic acid and synthesis method thereof
专利号:US-8933018-B2 优先权日:2011-02-07 标题 :Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof 发明人:GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA 权利人:GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA; REMPEX PHARMACEUTICALS INC 摘要:Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.
专利号:CN-105732563-B 优先权日:2016-03-23 标 题 :A kind of new method of the bromo- 3- of synthesis 9- (2- acetyl bromides) -10,11- dihydro -5H- dibenzo [c, g] chromene -8 (9h) -one
专利号:US-7825149-B2 优先权日:2006-01-19 标 题 :Substituted imidazoles 发明人:CHUBB NATHAN ANTHONY LOGAN; COX MARK ROGER; DAUVERGNE JEROME SEBASTIEN; EWIN RICHARD ANDREW; LAURET CHRISTELLE 权利人:PFIZER LTD 摘要:This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.